The Horticultural Activity of Touching Soil and the Autonomic Nervous Stress Response of Patients with Brain Disease

2020 ◽  
Vol 14 ◽  
Author(s):  
Jacquelyn S. Christensen ◽  
Heather Wild ◽  
Erin S. Kenzie ◽  
Wayne Wakeland ◽  
Deborah Budding ◽  
...  

2006 ◽  
Vol 25 (1) ◽  
pp. 32-39
Author(s):  
C.C. Grant ◽  
N. Claassen ◽  
M. Viljoen

This study investigated the influence of skydiving and freefall, as well as that of visualisation, on the autonomic nervous system balance. The results showed a shift towards sympathetic dominance in the autonomic nervous system balance during skydiving and freefall. This shift was statistically significant in the inexperienced, but not in the experienced skydivers. A similar autonomic stress response was seen in the laboratory during visualisation of skydiving. Further studies are necessary to ascertain whether a difference exists between the extent to which experienced and inexperienced skydivers can induce the biological stress response through visualisation.


2019 ◽  
Vol 476 (21) ◽  
pp. 3141-3159 ◽  
Author(s):  
Meiru Si ◽  
Can Chen ◽  
Zengfan Wei ◽  
Zhijin Gong ◽  
GuiZhi Li ◽  
...  

Abstract MarR (multiple antibiotic resistance regulator) proteins are a family of transcriptional regulators that is prevalent in Corynebacterium glutamicum. Understanding the physiological and biochemical function of MarR homologs in C. glutamicum has focused on cysteine oxidation-based redox-sensing and substrate metabolism-involving regulators. In this study, we characterized the stress-related ligand-binding functions of the C. glutamicum MarR-type regulator CarR (C. glutamicum antibiotic-responding regulator). We demonstrate that CarR negatively regulates the expression of the carR (ncgl2886)–uspA (ncgl2887) operon and the adjacent, oppositely oriented gene ncgl2885, encoding the hypothetical deacylase DecE. We also show that CarR directly activates transcription of the ncgl2882–ncgl2884 operon, encoding the peptidoglycan synthesis operon (PSO) located upstream of carR in the opposite orientation. The addition of stress-associated ligands such as penicillin and streptomycin induced carR, uspA, decE, and PSO expression in vivo, as well as attenuated binding of CarR to operator DNA in vitro. Importantly, stress response-induced up-regulation of carR, uspA, and PSO gene expression correlated with cell resistance to β-lactam antibiotics and aromatic compounds. Six highly conserved residues in CarR were found to strongly influence its ligand binding and transcriptional regulatory properties. Collectively, the results indicate that the ligand binding of CarR induces its dissociation from the carR–uspA promoter to derepress carR and uspA transcription. Ligand-free CarR also activates PSO expression, which in turn contributes to C. glutamicum stress resistance. The outcomes indicate that the stress response mechanism of CarR in C. glutamicum occurs via ligand-induced conformational changes to the protein, not via cysteine oxidation-based thiol modifications.


1970 ◽  
Vol 126 (2) ◽  
pp. 311-329 ◽  
Author(s):  
J. G. Widdicombe

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