Three-dimensional simulation of thrombus formation in Fontan circulation using patient-specific models of blood flow channel

2016 ◽  
Vol 2016.27 (0) ◽  
pp. C216
Author(s):  
Takuya TAKEUCHI ◽  
Koichi SUGHIMOTO ◽  
Ken-ichi TSUBOTA
Keyword(s):  
Blood Flow ◽  
Thrombus Formation ◽  
Three Dimensional ◽  
Fontan Circulation ◽  
Flow Channel ◽  
Patient Specific ◽  
Dimensional Simulation

Three-dimensional simulation of thrombus formation in Fontan circulation

2017 ◽  
Vol 2017 (0) ◽  
pp. J0230101
Author(s):  
Takuya TAKEUCHI ◽  
Koichi SUGHIMOTO ◽  
Ken-ichi TSUBOTA
Keyword(s):  
Thrombus Formation ◽  
Three Dimensional ◽  
Fontan Circulation ◽  
Dimensional Simulation

Mass transfer and blood flow in a patient-specific three-dimensional Willis circle

2021 ◽  
Vol 126 ◽  
pp. 105369
Author(s):  
Alessio Pignani ◽  
Ivan Di Venuta ◽  
Andrea Boghi ◽  
Fabio Gori
Keyword(s):  
Mass Transfer ◽  
Blood Flow ◽  
Three Dimensional ◽  
Patient Specific

Does the DSA reconstruction kernel affect hemodynamic predictions in intracranial aneurysms? An analysis of geometry and blood flow variations

2017 ◽  
Vol 10 (3) ◽  
pp. 290-296 ◽  
Author(s):  
P Berg ◽  
S Saalfeld ◽  
S Voß ◽  
T Redel ◽  
B Preim ◽  
...  
Keyword(s):  
Blood Flow ◽  
Intracranial Aneurysms ◽  
Three Dimensional ◽  
Patient Specific ◽  
Parent Artery ◽  
Imaging Data ◽  
Specific Flow ◽  
Aneurysm Neck ◽  
Velocity Magnitude ◽  
Reconstruction Kernel

BackgroundComputational fluid dynamics (CFD) blood flow predictions in intracranial aneurysms promise great potential to reveal patient-specific flow structures. Since the workflow from image acquisition to the final result includes various processing steps, quantifications of the individual introduced potential error sources are required.MethodsThree-dimensional (3D) reconstruction of the acquired imaging data as input to 3D model generation was evaluated. Six different reconstruction modes for 3D digital subtraction angiography (DSA) acquisitions were applied to eight patient-specific aneurysms. Segmentations were extracted to compare the 3D luminal surfaces. Time-dependent CFD simulations were carried out in all 48 configurations to assess the velocity and wall shear stress (WSS) variability due to the choice of reconstruction kernel.ResultsAll kernels yielded good segmentation agreement in the parent artery; deviations of the luminal surface were present at the aneurysm neck (up to 34.18%) and in distal or perforating arteries. Observations included pseudostenoses as well as noisy surfaces, depending on the selected reconstruction kernel. Consequently, the hemodynamic predictions show a mean SD of 11.09% for the aneurysm neck inflow rate, 5.07% for the centerline-based velocity magnitude, and 17.83%/9.53% for the mean/max aneurysmal WSS, respectively. In particular, vessel sections distal to the aneurysms yielded stronger variations of the CFD values.ConclusionsThe choice of reconstruction kernel for DSA data influences the segmentation result, especially for small arteries. Therefore, if precise morphology measurements or blood flow descriptions are desired, a specific reconstruction setting is required. Furthermore, research groups should be encouraged to denominate the kernel types used in future hemodynamic studies.

scholarly journals Two-Phase Non-Newtonian Pulsatile Blood Flow Simulations in a Rigid and Flexible Patient-Specific Left Coronary Artery (LCA) Exhibiting Multi-Stenosis

2021 ◽  
Vol 11 (23) ◽  
pp. 11361
Author(s):  
Abdulgaphur Athani ◽  
Nik Nazri Nik Ghazali ◽  
Irfan Anjum Badruddin ◽  
Abdullah Y. Usmani ◽  
Sarfaraz Kamangar ◽  
...  
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Left Coronary Artery ◽  
Solid Wall ◽  
Three Dimensional ◽  
Patient Specific ◽  
Maximum Pressure ◽  
Three Dimensional Model ◽  
Two Phase ◽  
Pressure Drops

Coronary artery disease (CAD) is stated as one of the most common causes of death all over the world. This article explores the influence of multi stenosis in a flexible and rigid left coronary artery (LCA) model using a multiphase blood flow system which has not yet been studied. Two-way fluid–solid interaction (FSI) is employed to achieve flow within the flexible artery model. A realistic three-dimensional model of multi-stenosed LCA was reconstructed based on computerized tomography (CT) images. The fluid domain was solved using a finite volume-based commercial software (FLUENT 2020). The fluid (blood) and solid (wall) domains were fully coupled by using the ANSYS Fluid-Structure Interaction solver. The maximum pressure drops, and wall shear stress was determined across the sever stenosis (90% AS). The higher region of displacement occurs at the pre-stenosis area compared to the other area of the left coronary artery model. An increase in blood flow velocity across the restricted regions (stenosis) in the LCA was observed, whereas the recirculation zone at the post-stenosis and bifurcation regions was noted. An overestimation of hemodynamic descriptors for the rigid models was found as compared to the FSI models.

scholarly journals Blood flow and coherent vortices in the normal and aneurysmatic aortas: a fluid dynamical approach to intra-luminal thrombus formation

2011 ◽  
Vol 8 (63) ◽  
pp. 1449-1461 ◽  
Author(s):  
Jacopo Biasetti ◽  
Fazle Hussain ◽  
T. Christian Gasser
Keyword(s):  
Fluid Dynamics ◽  
Blood Flow ◽  
Shear Stress ◽  
Cardiac Cycle ◽  
Thrombus Formation ◽  
Aortic Aneurysms ◽  
Patient Specific ◽  
Clear Correlation ◽  
Complex Flow ◽  
Dynamics Simulations

Abdominal aortic aneurysms (AAAs) are frequently characterized by the development of an intra-luminal thrombus (ILT), which is known to have multiple biochemical and biomechanical implications. Development of the ILT is not well understood, and shear–stress-triggered activation of platelets could be the first step in its evolution. Vortical structures (VSs) in the flow affect platelet dynamics, which motivated the present study of a possible correlation between VS and ILT formation in AAAs. VSs educed by the λ 2 -method using computational fluid dynamics simulations of the backward-facing step problem, normal aorta, fusiform AAA and saccular AAA were investigated. Patient-specific luminal geometries were reconstructed from computed tomography scans, and Newtonian and Carreau–Yasuda models were used to capture salient rheological features of blood flow. Particularly in complex flow domains, results depended on the constitutive model. VSs developed all along the normal aorta, showing that a clear correlation between VSs and high wall shear stress (WSS) existed, and that VSs started to break up during late systole. In contrast, in the fusiform AAA, large VSs developed at sites of tortuous geometry and high WSS, occupying the entire lumen, and lasting over the entire cardiac cycle. Downward motion of VSs in the AAA was in the range of a few centimetres per cardiac cycle, and with a VS burst at that location, the release (from VSs) of shear-stress-activated platelets and their deposition to the wall was within the lower part of the diseased artery, i.e. where the thickest ILT layer is typically observed. In the saccular AAA, only one VS was found near the healthy portion of the aorta, while in the aneurysmatic bulge, no VSs occurred. We present a fluid-dynamics-motivated mechanism for platelet activation, convection and deposition in AAAs that has the potential of improving our current understanding of the pathophysiology of fluid-driven ILT growth.

Simulation of personalised haemodynamics by various mounting positions of a prosthetic valve using computational fluid dynamics

2019 ◽  
Vol 64 (2) ◽  
pp. 147-156 ◽  
Author(s):  
Markus Bongert ◽  
Marius Geller ◽  
Werner Pennekamp ◽  
Volkmar Nicolas
Keyword(s):  
Blood Flow ◽  
Aortic Valve ◽  
Three Dimensional ◽  
Maximum Velocity ◽  
Heart Valve Disease ◽  
Patient Specific ◽  
Opening Angle ◽  
The European Union ◽  
Prosthetic Valves ◽  
Magnetic Resonance Imaging Mri

Abstract Diseases of the cardiovascular system account for nearly 42% of all deaths in the European Union. In Germany, approximately 12,000 patients receive surgical replacement of the aortic valve due to heart valve disease alone each year. A three-dimensional (3D) numerical model based on patient-specific anatomy derived from four-dimensional (4D) magnetic resonance imaging (MRI) data was developed to investigate preoperatively the flow-induced impact of mounting positions of aortic prosthetic valves to select the best orientation for individual patients. Systematic steady-state analysis of blood flow for different rotational mounting positions of the valve is only possible using a virtual patient model. A maximum velocity of 1 m/s was used as an inlet boundary condition, because the opening angle of the valve is at its largest at this velocity. For a comparative serial examination, it is important to define the standardised general requirements to avoid impacts other than the rotated implantation of the prosthetic aortic valve. In this study, a uniform velocity profile at the inlet for the inflow of the aortic valve and the real aortic anatomy were chosen for all simulations. An iterative process, with the weighted parameters flow resistance (1), shear stress (2) and velocity (3), was necessary to determine the best rotated orientation. Blood flow was optimal at a 45° rotation from the standard implantation orientation, which will offer a supply to the coronary arteries.

scholarly journals Three-dimensional simulation of blood flow in human thoracic aorta

2010 ◽  
Vol 30 (5) ◽  
pp. 516-520
Author(s):  
Ya-fei XIANG ◽  
Jun-feng YIN ◽  
Li XIANG ◽  
Tian-yu SHAO ◽  
Jun-feng HUANG ◽  
...  
Keyword(s):  
Blood Flow ◽  
Thoracic Aorta ◽  
Three Dimensional ◽  
Dimensional Simulation

Assessment of Invasive Fractional Flow Reserve Procedures Using Computational Fluid Dynamics

2020 ◽  
Author(s):  
Yasser Abuouf ◽  
Muhamed Albadawi ◽  
Shinichi Ookawara ◽  
Mahmoud Ahmed
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Pressure Drop ◽  
Fractional Flow Reserve ◽  
Treatment Plan ◽  
Three Dimensional ◽  
Patient Specific ◽  
Concomitant Treatment ◽  
Fractional Flow ◽  
Flow Reserve

Abstract Coronary artery disease is the abnormal contraction of heart supply blood vessel. It may lead to major consequences such as heart attack and death. This narrowing in the coronary artery limits the oxygenated blood flow to the heart. Thus, diagnosing its severity helps physicians to select the appropriate treatment plan. Fractional Flow Reserve (FFR) is one of the most accurate methods to pinpoint the stenosis severity. The advantages of FFR are high accuracy, immediate estimation of the severity of the stenosis, and concomitant treatment using balloon or stent. Nevertheless, the main disadvantage of the FFR is being an invasive procedure that requires an incision under anesthesia. Moreover, inserting the guidewire across the stenosis may result in a ‘tight-fit’ between the vessel lumen and the guidewire. This may cause an increase in the measured pressure drop, leading to a false estimation of the blood flow parameters. To estimate the errors in diagnosis procedures, a comprehensive three-dimensional model blood flow along with guidewire is developed. Reconstructed three-dimensional coronary artery geometry from a patient-specific scan is used. Blood is considered non-Newtonian and the flow is pulsatile. The comprehensive model is numerically simulated using boundary conditions. Based on the predicted results, the ratio between pressure drop and distal dynamic pressure (CDP) is studied. The predicted results for each case are compared with the control case (the case without guidewire) and analyzed. It was found that simulating the model by placing the guidewire at a full position prior to the simulation leads to an overestimation of the CDP as it increases by 34.3%. However, simulating the procedure of guidewire insertion is more accurate. It shows that the CDP value increases by 7%.

192 Three-dimensional simulation of behavior of malaria infected red blood cell in blood flow

2010 ◽  
Vol 2010.45 (0) ◽  
pp. 184-185
Author(s):  
Keita NAKAAKI ◽  
Yohsuke IMAI ◽  
Hitoshi KONDO ◽  
Takuji ISHIKAWA ◽  
Lim Chwee Teck ◽  
...  
Keyword(s):  
Blood Flow ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Three Dimensional ◽  
Dimensional Simulation
Sign in / Sign up

Export Citation Format

Share Document