scholarly journals Role of IL-17 gene polymorphisms in osteoarthritis: A meta-analysis based on observational studies

2020 ◽  
Vol 8 (11) ◽  
pp. 2280-2293
Author(s):  
Hao-Yu Yang ◽  
Yu-Zhou Liu ◽  
Xin-Die Zhou ◽  
Yong Huang ◽  
Nan-Wei Xu
Keyword(s):  
Gene Polymorphisms ◽  
Observational Studies ◽  
Meta Analysis

Mechanical Thromboprophylaxis in Critically Ill Patients: A Systematic Review and Meta-Analysis

2006 ◽  
Vol 15 (4) ◽  
pp. 402-412 ◽  
Author(s):  
Anthony Limpus ◽  
Wendy Chaboyer ◽  
Ellen McDonald ◽  
Lukman Thalib
Keyword(s):  
Intensive Care ◽  
Randomized Controlled Trials ◽  
Observational Studies ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Trauma Patients ◽  
Intensive Care Patients ◽  
Randomized Controlled ◽  
Confounding Variables

• Objective To systematically review the randomized trials, observational studies, and survey evidence on compression and pneumatic devices for thromboprophylaxis in intensive care patients. • Methods Published studies on the use of compression and pneumatic devices in intensive care patients were assessed. A meta-analysis was conducted by using the randomized controlled trials. • Results A total of 21 relevant studies (5 randomized controlled trials, 13 observational studies, and 3 surveys) were found. A total of 811 patients were randomized in the 5 randomized controlled trials; 3421 patients participated in the observational studies. Trauma patients only were enrolled in 4 randomized controlled trials and 4 observational studies. Meta-analysis of 2 randomized controlled trials with similar populations and outcomes revealed that use of compression and pneumatic devices did not reduce the incidence of venous thromboembolism. The pooled risk ratio was 2.37, indicative of favoring the control over the intervention in reducing the deep venous thrombosis; however, the 95% CI of 0.57 to 9.90 indicated no significant differences between the intervention and the control. A range of methodological issues, including bias and confounding variables, make meaningful interpretation of the observational studies difficult. • Conclusions The limited evidence suggests that use of compressive and pneumatic devices yields results not significantly different from results obtained with no treatment or use of low-molecular-weight heparin. Until large randomized controlled trials are conducted, the role of mechanical approaches to thromboprophylaxis for intensive care patients remains uncertain.

scholarly journals Association of miR-146a polymorphism rs2910164 and type 2 diabetes risk: a meta-analysis

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052093131
Author(s):  
Liqing Cheng ◽  
Min Zhou ◽  
Dongmei Zhang ◽  
Bing Chen
Keyword(s):  
Type 2 Diabetes ◽  
Gene Polymorphisms ◽  
Disease Duration ◽  
Genetic Model ◽  
Meta Analysis ◽  
Confounding Factors ◽  
Dominant Model ◽  
Subgroup Analyses

Objective Circulating miR-146a is aberrantly expressed in patients with type 2 diabetes (T2D), probably resulting from gene polymorphisms. However, the role of polymorphism rs2910164 in T2D pathogenesis remains controversial. Thus, we designed a meta-analysis to investigate the association between rs2910164 and T2D. Methods PubMed and Embase were searched for eligible papers in English published through September 2, 2019. Random or fixed effect models were used to determine risk estimates according to heterogeneities. Results Four studies, involving 2,069 patients and 1,950 controls, were included. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to pool the effect size. The pooled ORs and 95% CIs were 1.501 (0.887–2.541), 1.102 (0.931–1.304), 1.276 (0.900–1.811), 1.204 (0.878–1.652), 1.238 (0.880–1.740), and 1.350 (0.904–2.016) under the homozygote, heterozygote (CG vs. GG and CC vs. CG), dominant, allele, and recessive models, respectively. Heterogeneity was detected in most genetic models, with subgroup analyses performed by ethnicity, genotyping method, and disease duration. The co-dominant model was determined to be the most appropriate genetic model. Conclusions Our findings suggested that polymorphism rs2910164 is not correlated with T2D susceptibility. However, the results should be interpreted with caution because of confounding factors.

scholarly journals The role of minimal access valve surgery in the elderly. A meta-analysis of observational studies

2016 ◽  
Vol 33 ◽  
pp. 164-171 ◽  
Author(s):  
Marco Moscarelli ◽  
Sam Emmanuel ◽  
Thanos Athanasiou ◽  
Giuseppe Speziale ◽  
Khalil Fattouch ◽  
...  
Keyword(s):  
Observational Studies ◽  
Meta Analysis ◽  
The Elderly ◽  
Valve Surgery ◽  
Minimal Access ◽  
Surgery In The Elderly

scholarly journals Role of serum ferritin level on overall survival in patients with myelodysplastic syndromes: Results of a meta-analysis of observational studies

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0179016 ◽  
Author(s):  
Claudia Pileggi ◽  
Maddalena Di Sanzo ◽  
Valentina Mascaro ◽  
Maria Grazia Marafioti ◽  
Francesco Saverio Costanzo ◽  
...  
Keyword(s):  
Overall Survival ◽  
Serum Ferritin ◽  
Myelodysplastic Syndromes ◽  
Observational Studies ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Meta Analysis

scholarly journals P.063 Endovascular Treatment of Acute Ischemic Stroke in Patients with Pre-morbid Disability: A Meta-analysis

2021 ◽  
Vol 48 (s3) ◽  
pp. S37-S37
Author(s):  
F Bala ◽  
B Beland ◽  
A Ganesh
Keyword(s):  
Ischemic Stroke ◽  
Endovascular Treatment ◽  
Random Effects ◽  
Observational Studies ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Endovascular Thrombectomy ◽  
Randomized Controlled ◽  
Stroke Disability

Background: Practice-changing trials of endovascular thrombectomy (EVT) for acute stroke excluded patients with pre-morbid disability. Observational studies may inform the role of EVT in this population. We performed a meta-analysis to estimate the effect of EVT in patients with pre-morbid disability. Methods: We adhered to PRISMA guidelines and searched Medline and Embase for studies describing EVT in adults with and without pre-morbid disability with stroke. Random-effects meta-analysis was used to pool outcomes, including favorable outcomes (mRS=0-2 or return to baseline), no increase in disability at 90 days, symptomatic ICH (sICH) and 90-day mortality. Results: We included 8 studies with 5570 patients (mRS 3-5=863, mRS 0-2=4,707). Patients with pre-morbid disability were more likely to return to their baseline mRS (aOR 2.53, 95% CI=1.47-4.36), although they had higher 90-day mortality (aOR=2.21, 95% CI=1.66-2.93). aOR for favorable outcome (aOR=0.83, 95% CI=0.67-1.03) or sICH (aOR=1.07, 95% CI=0.74-1.54) was not significantly different between groups. Conclusions: Observational studies suggest that EVT is safe in patients with pre-stroke disability and may result in comparable return to pre-stroke status as in patients without such disability. These findings argue against the routine exclusion of patients with pre-morbid disability from EVT and merit validation with randomized controlled trials.

scholarly journals Prevalence and Risk Factors for Spasticity After Stroke: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Huangling Zeng ◽  
Jian Chen ◽  
Yang Guo ◽  
Sheng Tan
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Observational Studies ◽  
Hemorrhagic Stroke ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Stroke Patients ◽  
Pooled Prevalence ◽  
Severe Spasticity

Background: Spasticity is a common sequela of stroke. The incidence of poststroke spasticity (PSS) has not been systematically reviewed in recent years, and some risk factors remain debated. This systematic review and meta-analysis was conducted to determine the prevalence and risk factors for PSS.Methods: We searched electronic databases (PubMed, Embase, Cochrane Library, CNKI, WANFANG and CBM) inception to May 12, 2020. Observational studies summarizing the incidence or risk factors for PSS were included. Only cohort studies were enrolled in meta-analysis. For risk factors examined in at least three different studies, we combined effects into odds ratios (OR) and 95% confidence intervals (CI).Results: One thousand four hundred sixty-seven studies were retrieved and 23 were involved in meta-analysis. The pooled prevalence of spasticity after stroke was 25.3% and that after the first-ever stroke was 26.7%. The incidence of spasticity after the first-ever stroke with paresis was 39.5%. The prevalence of disabling or severe spasticity (MAS ≥ 3) in stroke patients with paresis was 9.4% (95% CI 0.056–0.133), and severe spasticity was 10.3% (95% CI 0.058–0.149). Moderate to severe paresis (OR = 6.573, 95% CI 2.579–16.755, I2 = 0.0%), hemorrhagic stroke (OR = 1.879, 95% CI 1.418–2.490, I2 = 27.3%) and sensory disorder were risk factors for PSS.Conclusions: The incidence of PSS was significantly higher in stroke patients with paresis. Patients with moderate to severe paresis and sensory disorder should be closely followed up. The role of hemorrhagic stroke in predicting PSS remains to be further explored.

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