scholarly journals Antibacterial Activity and DNA Binding Properties of Bivalent Metal Complexes of Cuminaldehyde Acetoylhydrazone

2021 ◽  
Vol 37 (5) ◽  
pp. 1125-1131
Author(s):  
Y.B. Nagamani ◽  
K. Hussain Reddy ◽  
K. Srinivasulu ◽  
D. Dhanalakshmi ◽  
K. Anuja
Keyword(s):  
Antibacterial Activity ◽  
Dna Binding ◽  
Binding Constants ◽  
Dna Interactions ◽  
Bivalent Metal ◽  
Binding Properties ◽  
Hydrazone Ligand ◽  
Metal Compounds ◽  
Physico Chemical ◽  
Dna Binding Properties

Metallo-hydrazones having the formula [M(IBAH)2] (where, M = Ni(II), Cu(II) and Zn(II); IBAH = p-Isopropylbenzaldehyde acetoylhydrazone) are prepared and confirmed on the basis of physico-chemical and spectral analyses. Conductivity data revealed that the complexes are non-electrolytes. Metal-DNA interactions are investigated using absorption spectrophotometry. Binding constant (Kb) data revealed that the copper complex interact DNA more strongly than other complexes. Antibacterial activity studies indicated higher activity for complexes than the metal free hydrazone ligand. The copper compound displays higher activity. DNA binding constants are correlated with the activity of metal compounds in this article.

Synthesis and DNA-binding Properties of a Cationic Seven-coordinate Manganese(II) Complex Formed with the Tripodal Ligand Tris(Nmethylbenzimidazol- 2-ylmethyl)amine and Salicylate

2012 ◽  
Vol 67 (8) ◽  
pp. 819-826 ◽  
Author(s):  
Huilu Wu ◽  
Ying Bai ◽  
Jingkun Yuan ◽  
Hua Wang ◽  
Guolong Pan ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Mode ◽  
X Ray Diffraction ◽  
Binding Properties ◽  
Tripodal Ligand ◽  
Spectrophotometric Methods ◽  
Physico Chemical ◽  
Dna Binding Properties ◽  
Hydroxyl Radical Scavenge

A ternary cationic Mn(II) complex with the tripodal ligand tris(2-(N-methyl) benzimidazylmethyl)amine (Mentb), salicylate and DMF as ligands and nitrate as counterion, [Mn(Mentb)(salicylate)DMF](NO3), was synthesized and characterized by physico-chemical and spectroscopic methods. The crystal structure of the Mn(II) complex has been determined by single-crystal X-ray diffraction and revealed that the central Mn(II) atom is seven-coordinated. The DNA-binding properties of the Mn(II) complex were investigated by spectrophotometric methods and viscosity measurements, and the results suggest that the Mn(II) complex binds to DNA via an intercalation binding mode. Additionally, the complex exhibited potential hydroxyl radical scavenge properties in in vitro studies

Tuned structure and DNA binding properties of metal complexes based on a new 4-acylpyrazolone derivative

2020 ◽  
Vol 44 (6) ◽  
pp. 2281-2290
Author(s):  
Wei Xi ◽  
Fu-Qiang Song ◽  
Xue-Li Xia ◽  
Xue-Qin Song
Keyword(s):  
Dna Binding ◽  
Transition Metal ◽  
Metal Complexes ◽  
Metal Cations ◽  
Transition Metal Compounds ◽  
Binding Properties ◽  
Metal Compounds ◽  
Dna Binding Properties

The structure and DNA binding performance of three transition metal compounds based on a new pyrazolone ligand were tuned effectively by changing both metal cations and anions.

scholarly journals DNA Interactions with Ruthenium(II) Polypyridine Complexes Containing Asymmetric Ligands

2005 ◽  
Vol 3 (1-2) ◽  
pp. 15-28 ◽  
Author(s):  
Hui Chao ◽  
Liang-Nian Ji
Keyword(s):  
Nucleic Acid ◽  
Dna Binding ◽  
Binding Modes ◽  
Dna Interactions ◽  
Binding Properties ◽  
The Past ◽  
Polypyridine Complexes ◽  
Nucleic Acid Structures ◽  
Dna Binding Properties ◽  
Shape And Size

In an attempt to probe nucleic acid structures, numerous Ru(II) complexes with different ligands have been synthesized and investigated. In this contribution we focus on the DNA-binding properties of ruthenium(II) complexes containing asymmetric ligands that have attracted little attention in the past decades. The influences of the shape and size of the ligand on the binding modes, affinity, enantioselectivities and photocleavage of the complexes to DNA are described.

scholarly journals Reversible photoswitching of the DNA-binding properties of styrylquinolizinium derivatives through photochromic [2 + 2] cycloaddition and cycloreversion

2020 ◽  
Vol 16 ◽  
pp. 111-124 ◽  
Author(s):  
Sarah Kölsch ◽  
Heiko Ihmels ◽  
Jochen Mattay ◽  
Norbert Sewald ◽  
Brian O Patrick
Keyword(s):  
Dna Binding ◽  
Diffraction Analysis ◽  
Binding Constants ◽  
Binding Modes ◽  
Reaction Products ◽  
X Ray Diffraction ◽  
Binding Properties ◽  
X Ray ◽  
Spectroscopic Analyses ◽  
Dna Binding Properties

It was demonstrated that styrylquinolizinium derivatives may be applied as photoswitchable DNA ligands. At lower ligand:DNA ratios (≤1.5), these compounds bind to duplex DNA by intercalation, with binding constants ranging from K b = 4.1 × 104 M to 2.6 × 105 M (four examples), as shown by photometric and fluorimetric titrations as well as by CD and LD spectroscopic analyses. Upon irradiation at 450 nm, the methoxy-substituted styrylquinolizinium derivatives form the corresponding syn head-to-tail cyclobutanes in a selective [2 + 2] photocycloaddition, as revealed by X-ray diffraction analysis of the reaction products. These photodimers bind to DNA only weakly by outside-edge association, but they release the intercalating monomers upon irradiation at 315 nm in the presence of DNA. As a result, it is possible to switch between these two ligands and likewise between two different binding modes by irradiation with different excitation wavelengths.

Homologous 1,3,5-triarylpyrazolines: synthesis, CH⋯π interactions guided self-assembly and effect of alkyloxy chain length on DNA binding properties

2014 ◽  
Vol 38 (11) ◽  
pp. 5617-5625 ◽  
Author(s):  
Faiza Anam ◽  
Asghar Abbas ◽  
Kong Mun Lo ◽  
Zia-ur-Rehman Zia-ur-Rehman ◽  
Shahid Hameed ◽  
...  
Keyword(s):  
Dna Binding ◽  
Chain Length ◽  
Self Assembly ◽  
Binding Constants ◽  
Binding Properties ◽  
Π Interactions ◽  
Self Assembled ◽  
Dna Binding Properties

The synthesis, CH⋯π interactions-driven self-assembled structure and DNA binding properties (105–106M−1binding constants) of new homologous 1,3,5-triaryl-2-pyrazolines are reported.

Heterocyclic thioamide/phosphine mixed-ligand silver(I) complexes: Synthesis, molecular structures, DNA-binding properties and antibacterial activity

Polyhedron ◽  
2018 ◽  
Vol 151 ◽  
pp. 131-140 ◽  
Author(s):  
Despoina Varna ◽  
Eleni Kapetanaki ◽  
Alexandra Koutsari ◽  
Antonios G. Hatzidimitriou ◽  
George Psomas ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Dna Binding ◽  
Mixed Ligand ◽  
Molecular Structures ◽  
Binding Properties ◽  
Dna Binding Properties

scholarly journals The B. subtilis Rok protein compacts and organizes DNA by bridging

2019 ◽  
Author(s):  
L. Qin ◽  
A.M. Erkelens ◽  
D. Markus ◽  
R.T. Dame
Keyword(s):  
Dna Binding ◽  
Dna Binding Protein ◽  
Gene Repression ◽  
Pseudomonas Sp ◽  
Binding Properties ◽  
E Coli ◽  
Physico Chemical ◽  
Global Organization ◽  
Chemical Conditions ◽  
Dna Binding Properties

AbstractRok from Bacillus subtilis is an abundant DNA binding protein similar in function to H-NS-like proteins found in many proteobacteria. Rok binds across the genome with a preference for A/T rich DNA. Such DNA often contains genes of foreign origin that are silenced due to Rok binding. Rok also has been implied in global organization of the B. subtilis genome. However, how Rok binds to DNA and how it represses transcription is unclear. Also, it is unknown whether Rok-mediated gene repression can be induced or relieved following changes in physico-chemical conditions, as noted for H-NS-like proteins. Here we investigate the DNA binding properties of Rok and determine the effects of physico-chemical conditions on these properties. We demonstrate that Rok is a DNA bridging protein similar to H-NS like proteins from E. coli (H-NS), Pseudomonas sp. (MvaT) and Mycobacteria (Lsr2). Strikingly, unlike these proteins, the ability of Rok to bridge DNA is not affected by changes in physico-chemical conditions. Not being a direct sensor of such changes sets Rok apart from other H-NS like proteins. It implies the existence of other (protein-mediated) mechanisms to relieve Rok-mediated gene silencing in response to changes in environmental conditions.

Sign in / Sign up

Export Citation Format

Share Document