Global organization of neuronal activity only requires unstructured local connectivity

Modern electrophysiological recordings simultaneously capture single-unit spiking activities of hundreds of neurons spread across large cortical distances. Yet, this parallel activity is often confined to relatively low-dimensional manifolds. This implies strong coordination also among neurons that are most likely not even connected. Here, we combine in vivo recordings with network models and theory to characterize the nature of mesoscopic coordination patterns in macaque motor cortex and to expose their origin: We find that heterogeneity in local connectivity supports network states with complex long-range cooperation between neurons that arises from multi-synaptic, short-range connections. Our theory explains the experimentally observed spatial organization of covariances in resting state recordings as well as the behaviorally related modulation of covariance patterns during a reach-to-grasp task. The ubiquity of heterogeneity in local cortical circuits suggests that the brain uses the described mechanism to flexibly adapt neuronal coordination to momentary demands.

Evidence for widespread cytoplasmic structuring into mesoscopic condensates

Eukaryotic cytoplasm organizes itself via both membrane-bound organelles and membrane-less biomolecular condensates (BMCs). Known BMCs exhibit liquid-like properties and are typically visualized on the scale of ~1 um. They have been studied mostly by microscopy, examining select individual proteins. Here, we investigate the global organization of native cytoplasm with quantitative proteomics, using differential pressure filtration, size exclusion, and dilution experiments. These assays reveal that BMCs form throughout the cytosplasm, predominantly at the mesoscale of ~100 nm. Our data indicate that at least 18% of the proteome is organized via such mesoscale BMCs, suggesting that cells widely employ dynamic liquid-like clustering to organize their cytoplasm, at surprisingly small length scales.

Social Progress Index for Urban and Rural Areas of a Region: Evidence from Peru

The present study describes the methodological process proposed by the Social Progress Imperative Global Organization to calculate the Social Progress Index in urban and rural areas of the province of Huancayo, Peru, in 2020. The survey was based on 229 observations regarding basic human needs, foundations of well-being and opportunities. The result produced an index of 56.04 for urban areas and 53.98 for rural areas; results that are in the low and low middle range respectively, identifying deficiencies in the quality of economic policies, with respect to the sanitation service, where more than 30% do not have access to drinking water, and others. It was concluded that the index showed no improvement with respect to 2019, likewise the social gaps still persist and the well-being of the aforementioned population was not increased.

Spatiotemporal coordination in word-medial stop-lateral and s-stop clusters of American English

This paper is concerned with the relation between syllabic organization and intersegmental spatiotemporal coordination using Electromagnetic Articulometry recordings from seven speakers of American English (henceforth, English). Whereas previous work on English has focused on word-initial clusters (preceding a vowel whose identity was not systematically varied), the present work examined word-medial clusters /pl, kl, sp, sk/ in the context of three different vowel heights (high, mid, low). Our results provide evidence for a global organization for the segments involved in these cluster-vowel combinations. This is reflected in a number of ways: compression of the prevocalic consonant and reduction of CV timing in the word-medial cluster case compared to its singleton paired word in both stop-lateral and s-stop clusters, early vowel initiation (as permitted by the clusters’ phonetic properties), and presence of compensatory relations between phonetic properties of different segments or intersegmental transitions within each cluster. In other words, we find that the global organization presiding over the segments partaking in these word-medial tautosyllabic CCVs is pleiotropic, that is, simultaneously expressed in multiple phonetic exponents rather than via a privileged metric such as c-center stability or any other such given single measure employed in previous works.

The Sudan Years

Chapter 4 explores the years after 1991, when Bin Laden was given sanctuary in Sudan. Five years later he and his followers were expelled. The Sudan years were an exceptionally busy period of building alliances and laying the groundwork for attacks on U.S. embassies and military installations in Saudi Arabia, Yemen, Nairobi, and Tanzania. At the same time, Bin Laden was supporting militants across the Muslim world and funding military instructors in training camps in Afghanistan, Southeast Asia, and East Africa. He was also seeking out terrorist expertise wherever he could find it. One of those places was Iran, which for a period became a sleeping partner in Bin Laden’s terrorism business. Above all, he was working to integrate Arab and North African exiled militants into a coherent, global organization. From Sudan, Bin Laden assisted his Egyptian allies in their terrorist campaign in Egypt, funded experimentation with the use of liquids bombs to blow up international commercial airliners, made plans to set up a base in the Balkans for Al Qaeda, set up a business office in London, and initiated preparations for the 1998 bombings of the U.S. embassies in Kenya and Tanzania.

Collaborative Advantage

In an era of rapid international economic integration, how do countries interact, innovate, and compete in industries, like energy, that are fundamental to national interests? Collaborative Advantage: Forging Green Industries in the New Global Economy examines the development of wind and solar industries, two sectors of historic importance that have long been the target of ambitious public policy. As wind and solar grew from cottage industries into $300 billion global sectors, China, Germany, and the United States each developed distinct constellations of firms with starkly different technical capabilities. The book shows that globalization itself has reinforced such distinct national patterns of industrial specialization. Economically, globalization has created opportunities for firms to specialize through collaboration with others. Politically, new possibilities for specialization have allowed firms to repurpose existing domestic institutions for application in new industries. Against the backdrop of policy efforts that have generally failed to grasp the cross-national nature of innovation, the book offers a novel explanation for both the causes of changes in the global organization of innovation and their impact on domestic politics. As interdependence in global supply chains has again come under fire in the wake of the Covid-19 pandemic, Collaborative Advantage challenges the notion that globalization is primarily about competition, highlighting instead the central role of collaboration in the global economy, particularly in clean energy industries critical to solving the climate crisis.

Introduction

The introduction describes the main puzzle to be explained in the book, briefly previews the argument, and then shows why the question it asks is both theoretically and empirically important. As wind and solar grew from cottage industries into $300 billion global sectors, China, Germany, and the United States each developed distinct constellations of firms with starkly different technical capabilities. The chapter argues that globalization itself has such reinforced distinct national patterns of industrial specialization. Economically, globalization has created opportunities for firms to specialize through collaboration with others. Politically, new possibilities for specialization have allowed firms to repurpose existing domestic institutions for application in new industries. Against the backdrop of policy efforts that have generally failed to grasp the cross-national nature of innovation, the chapter offers a novel explanation for both the causes of changes in the global organization of innovation and their impact on domestic politics.

Framing in interactive academic talk

Framing involves how language users conceptualize what is happening in interaction for situated interpretation of roles, purposes, expectations, and sequences of action, thus show significant conceptual relevance to the analysis of routinized institutional communication. Having established a working definition of framing based on an intensive review of previous research, this study investigates university students’ and tutors’ framing behaviors in interactive small group talk. Two types of framing-in-interaction, -alternate framing of a single situation and co-framing within/beyond speaker role boundary-, are identified, examined, and characterized from a conversation-analytic perspective. The findings suggest that alternate framings co-occur with traceable interactional devices for sequential organization when the single situation at talk takes on divergent meaning potentials to be accessed. Co-framings happen when at least one (group) of participants is highly goal-oriented, showing conditional relevance to the prior courses of action and more explicit negotiation of epistemic stances. Framing, therefore, can be arguably taken as a global organization resource to characterize contextualization in institutional communication.