Impact on Health-Related Quality of Life of a Switch From Enfuvirtide to Raltegravir Among Multidrug-Resistant HIV-1–Infected Patients: A Randomized Open-Label Trial (EASIER-ANRS 138)

2010 ◽  
Vol 11 (5) ◽  
pp. 283-293 ◽  
Author(s):  
Thomas Boulet ◽  
Juliette Pavie ◽  
Isabelle Charreau ◽  
Joséphine Braun ◽  
Jacques Reynes ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multidrug Resistant ◽  
Health Related Quality ◽  
Open Label ◽  
Related Quality ◽  
Health Related ◽  
Open Label Trial ◽  
Hiv 1

scholarly journals Health Related Quality of Life of Caregivers of Children and Adolescents With Phenylketonuria: A Systematic Review

2021 ◽  
Vol 8 ◽  
pp. 2333794X2110653
Author(s):  
Deepa Shaji Thomas ◽  
Divya K. Y. ◽  
Judie Arulappan
Keyword(s):  
Quality Of Life ◽  
Health Related Quality ◽  
Open Label ◽  
Cross Sectional ◽  
Related Quality ◽  
Health Related ◽  
Open Label Trial ◽  
Cross Sectional Studies ◽  
The Impact

Introduction. Caregivers of children with chronic illness are at risk of having impairment in their quality of life (QOL). We systematically reviewed the available literature related to the Health Related Quality Of Life (HRQOL) of caregivers of children with Phenylketonuria (PKU). Methods. We comprehensively searched in electronic databases including Scopus, Science Direct, CINAHL, Medline, PubMed, Google scholar, and ProQuest. The search criteria included studies with samples more than one, children suffering from PKU, exploring parents or primary caregiver’s HRQOL, published from 2010 to 2020, full article available for download and published in English. Eight studies including 5 cross sectional studies, 1 open label trial, and 2 surveys were systematically reviewed. Results. Seven out of 8 studies have established a negative correlation between PKU and parent’s HRQOL in at least 1 of the domains. In one study, the HRQOL of parents is higher than their population norms. Conclusion. Most of the caregivers had poor to moderate HRQOL. More studies are required to explore HRQOL of caregivers of children with PKU using similar tools and outcome measures addressing all the domains of HRQOL in order to have more clarity on the impact of PKU on caregiver’s HRQOL. Interventional studies might help in improving the HRQOL of caregivers.

HIV-1 impact on oral health-related quality of life: a cross-sectional study

AIDS Care ◽  
2020 ◽  
pp. 1-8
Author(s):  
Rúben Teófilo Vasconcelos Moreira Rocha Trindade ◽  
Joana Rita Oliveira Faria Marques ◽  
Marcos Alberto Gil da Veiga ◽  
Duarte Nuno da Silva Marques ◽  
António Duarte Sola Pereira da Mata
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Cross Sectional Study ◽  
Health Related Quality ◽  
Sectional Study ◽  
Cross Sectional ◽  
Related Quality ◽  
Health Related ◽  
Hiv 1

scholarly journals P249 Effect Size Of Open-label Versus Double-blind Administration Of Tiotropium In Trials Investigating Health-related Quality Of Life In Copd

Thorax ◽  
2014 ◽  
Vol 69 (Suppl 2) ◽  
pp. A186-A186 ◽  
Author(s):  
H. Schmidt ◽  
H. Kogler ◽  
S. Geier ◽  
T. Glaab ◽  
I. Leimer
Keyword(s):  
Quality Of Life ◽  
Effect Size ◽  
Health Related Quality ◽  
Open Label ◽  
Double Blind ◽  
Related Quality ◽  
Health Related

scholarly journals The effect of TB treatment on health-related quality of life for people with advanced HIV

2020 ◽  
Vol 24 (9) ◽  
pp. 910-915
Author(s):  
V. Opollo ◽  
X. Sun ◽  
R. Lando ◽  
S. Miyahara ◽  
T. S. Torres ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Preventive Therapy ◽  
Health Related Quality ◽  
Clinical Factors ◽  
Open Label ◽  
Tb Treatment ◽  
Related Quality ◽  
Health Related ◽  
Over Time

BACKGROUND: Study A5274 was an open-label trial of people with HIV (PLHIV) with CD4 cell count <50 cells/µL who were randomized to empirical TB treatment vs. isoniazid preventive therapy (IPT) in addition to antiretroviral therapy (ART). We evaluated health-related quality of life (HRQoL) by study arm, changes over time, and association with sociodemographic and clinical factors.METHODS: Participants aged >13 years were enrolled from outpatient clinics in 10 countries. HRQoL was assessed at Weeks 0, 8, 24 and 96 with questions about daily activity, hospital or emergency room visits, and general health status. We used logistic regression to examine HRQoL by arm and association with sociodemographic and clinical factors.RESULTS: Among 850 participants (424 empiric arm, 426 IPT arm), HRQoL improved over time with no difference between arms. At baseline and Week 24, participants with WHO Stage 3 or 4 events, or those who had Grade 3 or 4 signs/symptoms, were significantly more likely to report poor HRQoL using the composite of four HRQoL measures.CONCLUSION: HRQoL improved substantially in both arms during the study period. These findings show that ART, TB screening, and IPT can not only reduce mortality, but also improve HRQoL in PLHIV with advanced disease.

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