Spontaneous Fractures in the Mouse Mutant sfx Are Caused by Deletion of the Gulonolactone Oxidase Gene, Causing Vitamin C Deficiency

Abstract Background Micronutrient deficiencies are common in patients with inflammatory bowel disease (IBD). To date, the literature has focused on vitamin D, vitamin B12, and iron deficiencies. Methods We report a case series of 20 patients with IBD and vitamin C deficiency treated at a single tertiary care center. Results Sixteen (80%) patients had symptoms of clinical scurvy, including arthralgia, dry brittle hair, pigmented rash, gingivitis, easy bruising and/or brittle nails. Eighteen patients underwent a nutritional assessment, 10 (56%) patients reported complete avoidance of fruits and vegetables, and 3 (17%) reported reduced intake of fruits and vegetables. Conclusions Vitamin C deficiency should be considered in IBD patients, particularly those with reduced fruit/vegetable intake, as it can lead to significant signs and symptoms.

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Vitamin C in Human Health and Disease

Nutrients ◽

10.3390/nu13051595 ◽

2021 ◽

Vol 13 (5) ◽

pp. 1595

Author(s):

Dariusz Nowak

Keyword(s):

Eighteenth Century ◽

Vitamin C ◽

Human Health ◽

Citrus Fruit ◽

Ancient Egypt ◽

Vitamin Supplement ◽

Vitamin C Deficiency ◽

Health And Disease

Although the symptoms related to vitamin C deficiency were known in ancient Egypt and eighteenth century Scottish surgeon James Lind found that scurvy (a disease resulting from insufficient dietary ingestion of vitamin C) could be effectively treated with citrus fruit, this vitamin was discovered only in the year 1912 and then after 21 years it was chemically synthetized and introduced to the market as the first vitamin supplement [...]

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The multifactorial aetiology of gingival overgrowth: a case report illustrating diagnosis and management

Dental Update ◽

10.12968/denu.2019.46.7.662 ◽

2019 ◽

Vol 46 (7) ◽

pp. 662-671

Author(s):

Rachael Y Jablonski ◽

Bethany Rushworth ◽

Kathryn A Durey

Keyword(s):

Case Report ◽

Renal Transplantation ◽

Vitamin C ◽

Oral Hygiene ◽

Patient Engagement ◽

Surgical Intervention ◽

Gingival Overgrowth ◽

Vitamin C Deficiency ◽

Specialist Services ◽

Detailed Assessment

Gingival overgrowth is the enlargement of gingival tissues and has various underlying aetiological factors. This case report highlights the multifactorial aetiology of gingival overgrowth for a patient who was prescribed an immunosuppressive strategy following renal transplantation, had poor levels of oral hygiene and a diet deficient in fruit and vegetables. The report highlights the importance of a detailed assessment to identify all underlying factors and demonstrates how a referral to the specialist services for gingival overgrowth led to a diagnosis of vitamin C deficiency. It also illustrates how both patient engagement and a conservative cause-related therapy can achieve a satisfactory resolution without any surgical intervention. CPD/Clinical Relevance: This case report highlights the importance of a detailed assessment to diagnose all relevant underlying aetiological factors involved in the development of gingival overgrowth. It also illustrates how both patient engagement and a conservative cause-related therapy can achieve a satisfactory resolution of gingival overgrowth without any surgical intervention.

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