scholarly journals Cytokines and Bone Loss in a 5-Year Longitudinal Study-Hormone Replacement Therapy Suppresses Serum Soluble Interleukin-6 Receptor and Increases Interleukin-1-Receptor Antagonist: The Danish Osteoporosis Prevention Study

2000 ◽  
Vol 15 (8) ◽  
pp. 1545-1554 ◽  
Author(s):  
Bo Abrahamsen ◽  
Vagn Bonnevie-Nielsen ◽  
Ebbe Nils Ebbesen ◽  
Jeppe Gram ◽  
Henning Beck-Nielsen
Keyword(s):  
Hormone Replacement Therapy ◽  
Longitudinal Study ◽  
Bone Loss ◽  
Receptor Antagonist ◽  
Interleukin 6 ◽  
Hormone Replacement ◽  
Interleukin 1 ◽  
Osteoporosis Prevention ◽  
Prevention Study ◽  
Interleukin 6 Receptor

scholarly journals Interleukin-6 Blockade With Tocilizumab in Anakinra-Refractory Febrile Infection-Related Epilepsy Syndrome (FIRES)

2020 ◽  
Vol 7 ◽  
pp. 2329048X2097925
Author(s):  
Coral M. Stredny ◽  
Siobhan Case ◽  
Arnold J. Sansevere ◽  
MaryBeth Son ◽  
Lauren Henderson ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Interleukin 6 ◽  
Interleukin 1 ◽  
Refractory Status Epilepticus ◽  
Cognitive Outcomes ◽  
Epilepsy Syndrome ◽  
Immune System Dysfunction ◽  
Interleukin 6 Receptor ◽  
Pro Inflammatory Cytokines ◽  
New Onset

Febrile infection-related epilepsy syndrome (FIRES) is characterized by new onset refractory status epilepticus in a previously healthy child that is associated with poor cognitive outcomes and chronic epilepsy. Innate immune system dysfunction is hypothesized to be a key etiologic contributor, with a potential role for immunotherapy blocking pro-inflammatory cytokines, such as interleukin-1β and interleukin-6. We present a case of FIRES refractory to anakinra, an interleukin-1 receptor antagonist, subsequently treated with the ketogenic diet and tocilizumab, an interleukin-6 receptor antagonist, temporally associated with seizure cessation and a favorable 1-year outcome.

The effect of tocilizumab - an interleukin-6 receptor antagonist - on lipid levels in rheumatoid arthritis

2017 ◽  
Author(s):  
Ifigenia Kostoglou-Athanassiou ◽  
Lambros Athanassiou ◽  
Aikaterini Tzanavari ◽  
Charoula Katsavouni ◽  
Markos Kostopoulos ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Receptor Antagonist ◽  
Interleukin 6 ◽  
Lipid Levels ◽  
Interleukin 6 Receptor
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