scholarly journals Enabling high-speed wide-field dynamic imaging in multifocal photoacoustic computed microscopy: a simulation study

2016 ◽  
Vol 55 (14) ◽  
pp. 3724 ◽  
Author(s):  
Hongying Wan ◽  
Yihang Zhou ◽  
Leslie Ying ◽  
Jing Meng ◽  
Liang Song ◽  
...  
Author(s):  
L. F. R. Fell

The author considers that, while the internal combustion engine is not universally applicable to British railway traction, there is a wide field which can be more economically covered by the oil engine than by other means. Electric transmission is, in spite of high first cost, the most readily adaptable for use in conjunction with the oil engine, and possesses a balance of advantages over all other known systems. The oil-electric locomotive offers a long list of important advantages for railway operation not possessed by other systems. These advantages are, however, offset by high first cost for powers of 1,000 b.h.p. and over. A comparison is drawn between the first cost of steam and oil-electric locomotives for the various duties called for in the service of a British railway. This shows that, while the first cost of the oil-electric main line express passenger locomotive is three times that of the existing steam locomotive, the first costs of branch passenger, medium goods, and shunting steam and oil-electric engines are comparable. This is owing to the cost per brake horse-power required diminishing with increase of size in the case of the steam locomotive, whereas it remains constant in the case of the oil-electric. Owing to the high rate of acceleration necessary the use of the oil-electric system is considered unsuitable as a substitute for dependent electrification of suburban lines. The railway oil engine is a specialized requirement. It must be of the high-speed type running at speeds of up to 1,500 r.p.m., in order to reduce first cost and for other reasons. Details are given of various types of British compression-ignition engines which are considered suitable for British railway work. The author deduces that an engine of twelve-cylinder “V” type and an engine with six cylinders in line, both incorporating the same design and size of cylinder, would fill all the requirements which can be economically met by the oil engine on a British railway. He selects the single sleeve-valve engine design as having the greatest balance of advantages in its favour for railway purposes. Attention is drawn to the importance of simplifying the installation of the compression-ignition engine and various suggestions are put forward to this end. In conclusion the author stresses the importance of the railway companies giving a lead to the internal combustion engine industry as to the railway requirements in size and type of engine, and states that it is the purpose of his paper to assist those concerned in arriving at this immediately important decision.


2018 ◽  
Vol 114 (3) ◽  
pp. 504a-505a
Author(s):  
Mohammed Mahamdeh ◽  
Steve Simmert ◽  
Anna Łuchniak ◽  
Erik Schäffer ◽  
Jonathon Howard

Author(s):  
Jamie Soon ◽  
David Adams ◽  
Kishalay De ◽  
Antony Galla ◽  
Matthew Hankins ◽  
...  

2017 ◽  
Vol 83 (4) ◽  
Author(s):  
Alexander J. Klimas ◽  
Adolfo F. Viñas ◽  
Jaime A. Araneda

A one-dimensional electrostatic filtered Vlasov–Poisson simulation study is discussed. The transition from persisting to arrested Landau damping that is produced by increasing the strength of a sinusoidal perturbation on a background Vlasov–Poisson equilibrium is explored. Emphasis is placed on observed features of the electron phase-space distribution when the perturbation strength is near the transition value. A single ubiquitous waveform is found perturbing the space-averaged phase-space distribution at almost any time in all of the simulations; the sole exception is the saturation stage that can occur at the end of the arrested damping scenario. This waveform contains relatively strong, very narrow structures in velocity bracketing $\pm v_{\text{res}}$ – the velocities at which electrons must move to traverse the dominant field mode wavelength in one of its oscillation periods – and propagating with $\pm v_{\text{res}}$ respectively. Local streams of electrons are found in these structures crossing the resonant velocities from low speed to high speed during Landau damping and from high speed to low speed during Landau growth. At the arrest time, when the field strength is briefly constant, these streams vanish. It is conjectured that the expected transfer of energy between electrons and field during Landau growth or damping has been visualized for the first time. No evidence is found in the phase-space distribution to support recent well-established discoveries of a second-order phase transition in the electric field evolution. While trapping is known to play a role for larger perturbation strengths, it is shown that trapping plays no role at any time in any of the simulations near the transition perturbation strength.


2004 ◽  
Vol 287 (6) ◽  
pp. C1577-C1588 ◽  
Author(s):  
Ronghua ZhuGe ◽  
Kevin E. Fogarty ◽  
Stephen P. Baker ◽  
John G. McCarron ◽  
Richard A. Tuft ◽  
...  

Ca2+ sparks are highly localized Ca2+ transients caused by Ca2+ release from sarcoplasmic reticulum through ryanodine receptors (RyR). In smooth muscle, Ca2+ sparks activate nearby large-conductance, Ca2+-sensitive K+ (BK) channels to generate spontaneous transient outward currents (STOC). The properties of individual sites that give rise to Ca2+ sparks have not been examined systematically. We have characterized individual sites in amphibian gastric smooth muscle cells with simultaneous high-speed imaging of Ca2+ sparks using wide-field digital microscopy and patch-clamp recording of STOC in whole cell mode. We used a signal mass approach to measure the total Ca2+ released at a site and to estimate the Ca2+ current flowing through RyR [ ICa(spark)]. The variance between spark sites was significantly greater than the intrasite variance for the following parameters: Ca2+ signal mass, ICa(spark), STOC amplitude, and 5-ms isochronic STOC amplitude. Sites that failed to generate STOC did so consistently, while those at the remaining sites generated STOC without failure, allowing the sites to be divided into STOC-generating and STOC-less sites. We also determined the average number of spark sites, which was 42/cell at a minimum and more likely on the order of at least 400/cell. We conclude that 1) spark sites differ in the number of RyR, BK channels, and coupling ratio of RyR-BK channels, and 2) there are numerous Ca2+ spark-generating sites in smooth muscle cells. The implications of these findings for the organization of the spark microdomain are explored.


Author(s):  
Hyojin Kim ◽  
Jin Young Kim ◽  
Jinwoo Baik ◽  
Seonghee Cho ◽  
Chulhong Kim

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