scholarly journals Reflective mirror-based line-scan adaptive optics OCT for imaging retinal structure and function

2021 ◽  
Vol 12 (9) ◽  
pp. 5865
Author(s):  
Vimal Prabhu Pandiyan ◽  
Xiaoyun Jiang ◽  
James A. Kuchenbecker ◽  
Ramkumar Sabesan
Keyword(s):  
Adaptive Optics ◽  
Structure And Function ◽  
Line Scan ◽  
Reflective Mirror ◽  
Retinal Structure ◽  
And Function

scholarly journals Reflective mirror-based line-scan adaptive optics OCT

2021 ◽  
Author(s):  
Vimal Prabhu Pandiyan ◽  
Xiaoyun Jiang ◽  
James A Kuchenbecker ◽  
Ramkumar Sabesan
Keyword(s):  
High Resolution ◽  
Adaptive Optics ◽  
Ex Vivo ◽  
Optical Design ◽  
Structure And Function ◽  
Line Scan ◽  
Reflective Mirror ◽  
Retinal Structure ◽  
And Function

Line-scan OCT, incorporated with adaptive optics (AO), offers high resolution, speed and sensitivity for imaging retinal structure and function in vivo. Here, we introduce its implementation with reflective mirror-based afocal telescopes, optimized for imaging light-induced retinal activity (optoretinography) and weak retinal reflections at the cellular scale. A non-planar optical design was followed based on previous recommendations with key differences specific to a line-scan geometry. The three beam paths fundamental to an OCT system -illumination/sample, detection, and reference - were modeled in Zemax optical design software to yield theoretically diffraction-limited performance over a 2.2 deg. field-of-view and 1.5 D vergence range at the eye's pupil. The performance for imaging retinal structure was exemplified by cellular-scale visualization of retinal ganglion cells, macrophages, foveal cones, and rods in human observers. The performance for functional imaging was exemplified by resolving the light-evoked optical changes in foveal cone photoreceptors where the spatial resolution was sufficient for cone spectral classification at an eccentricity 0.3 deg. from the foveal center. This enabled the first in vivo demonstration of reduced S-cone (short-wavelength cone) density in the human foveola, thus far observed only in ex vivo histological preparations. Together, the feasibility for high resolution imaging of retinal structure and function demonstrated here holds significant potential for basic science and translational applications.

Adaptive optics line-scan OCT for high-speed imaging of retinal structure and function (Conference Presentation)

2020 ◽  
Author(s):  
Vimal Prabhu Pandiyan ◽  
Aiden M. Bertelli ◽  
James Kuchenbecker ◽  
Kevin C. Boyle ◽  
Tong Ling ◽  
...  
Keyword(s):  
Adaptive Optics ◽  
High Speed ◽  
Structure And Function ◽  
High Speed Imaging ◽  
Line Scan ◽  
Retinal Structure ◽  
And Function

Restoration of the Retinal Structure and Function after Injury

2013 ◽  
Author(s):  
Daniel V. Palanker
Keyword(s):  
Structure And Function ◽  
Retinal Structure ◽  
And Function

Abnormal Retinal Structure and Function of Mother Wistar Rats Supplemented Aspartame, Glutamate and Galactose

2016 ◽  
Vol 07 (04) ◽  
Author(s):  
Hassan IH El-Sayyad ◽  
Amora M Abou El-Naga ◽  
Soad A Khalifa
Keyword(s):  
Wistar Rats ◽  
Structure And Function ◽  
Retinal Structure ◽  
And Function

Retinal Structure and Function in Perinatally HIV-Infected and cART-Treated Children: A Matched Case–Control Study

2015 ◽  
Vol 56 (6) ◽  
pp. 3945 ◽  
Author(s):  
Nazli Demirkaya ◽  
Sophie Cohen ◽  
Ferdinand W. N. M. Wit ◽  
Michael D. Abramoff ◽  
Reinier O. Schlingemann ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Structure And Function ◽  
Matched Case ◽  
Retinal Structure ◽  
And Function ◽  
Matched Case Control Study ◽  
Control Study

scholarly journals Retinal Structure and Function in Achromatopsia

Ophthalmology ◽  
2014 ◽  
Vol 121 (1) ◽  
pp. 234-245 ◽  
Author(s):  
Venki Sundaram ◽  
Caroline Wilde ◽  
Jonathan Aboshiha ◽  
Jill Cowing ◽  
Colin Han ◽  
...  
Keyword(s):  
Structure And Function ◽  
Retinal Structure ◽  
And Function

scholarly journals CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function

2018 ◽  
Vol 27 (18) ◽  
pp. 3137-3153 ◽  
Author(s):  
Peter M Quinn ◽  
C Henrique Alves ◽  
Jan Klooster ◽  
Jan Wijnholds
Keyword(s):  
Structure And Function ◽  
Retinal Structure ◽  
And Function

scholarly journals Direct comparison of retinal structure and function in retinitis pigmentosa by co-registering microperimetry and optical coherence tomography

PLoS ONE ◽  
2019 ◽  
Vol 14 (12) ◽  
pp. e0226097 ◽  
Author(s):  
Jun Funatsu ◽  
Yusuke Murakami ◽  
Shunji Nakatake ◽  
Masato Akiyama ◽  
Kohta Fujiwara ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retinitis Pigmentosa ◽  
Structure And Function ◽  
Optical Coherence ◽  
Retinal Structure ◽  
And Function

scholarly journals Quantitative Analysis of Retinal Structure and Function in Two Chromosomally Altered Mouse Models of Down Syndrome

2020 ◽  
Vol 61 (5) ◽  
pp. 25
Author(s):  
Daniella B. Victorino ◽  
Jonah J. Scott-McKean ◽  
Mark W. Johnson ◽  
Alberto C. S. Costa
Keyword(s):  
Down Syndrome ◽  
Quantitative Analysis ◽  
Mouse Models ◽  
Structure And Function ◽  
Retinal Structure ◽  
And Function

scholarly journals Long-Term Rescue of Retinal Structure and Function by Rhodopsin RNA Replacement with a Single Adeno-Associated Viral Vector in P23H RHO Transgenic Mice

2012 ◽  
Vol 23 (4) ◽  
pp. 356-366 ◽  
Author(s):  
Haoyu Mao ◽  
Marina S. Gorbatyuk ◽  
Brian Rossmiller ◽  
William W. Hauswirth ◽  
Alfred S. Lewin
Keyword(s):  
Transgenic Mice ◽  
Viral Vector ◽  
Structure And Function ◽  
Retinal Structure ◽  
And Function
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