Blood Coagulation Sensing at the Point of Care

CLEO: 2015 ◽  
2015 ◽  
Author(s):  
Seemantini K. Nadkarni ◽  
Markandey Tripathi ◽  
Diane Tshikudi ◽  
Elizabeth van Cott ◽  
Zeinab Hajjarian
Keyword(s):  
Blood Coagulation ◽  
Point Of Care

scholarly journals Characterization of carbon-coated magnetic nanoparticles using clinical blood coagulation assays: effect of PEG-functionalization and comparison to silica nanoparticles

2014 ◽  
Vol 2 (24) ◽  
pp. 3753-3758 ◽  
Author(s):  
Lukas Bircher ◽  
Oliver M. Theusinger ◽  
Silvan Locher ◽  
Philipp Eugster ◽  
Birgit Roth-Z'graggen ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Blood Coagulation ◽  
Human Blood ◽  
Point Of Care ◽  
Blood Samples ◽  
Coagulation Assays ◽  
Carbon Coated ◽  
Human Blood Samples ◽  
Peg Functionalization

We use point-of-care-assays to study blood coagulation in human blood samples exposed to nanomagnets.

Blood coagulation dynamic testing sensor based on electromagnetic vibration

2019 ◽  
Vol 233 (6) ◽  
pp. 611-620
Author(s):  
Zhe Wang ◽  
Yuan-hua Yu ◽  
Zhan-jiang Yu ◽  
Qi-meng Chen
Keyword(s):  
Blood Coagulation ◽  
Electromagnetic Induction ◽  
Dynamic Testing ◽  
Point Of Care ◽  
Rapid Assessment ◽  
Business Community ◽  
Experimental Device ◽  
Response Analysis ◽  
Point Of Care Testing ◽  
Detection Techniques

Rapid detection techniques and methods of blood coagulation have attracted wide attention in academia and the business community in the presence of the increased demands for rapid assessment (point-of-care testing) of patients from surgery, intensive care unit, and other departments. The differential equation of vibration system composed of elastic support and electromagnetic induction devices was set up using the principle of damping vibration and establishing the dynamics model; meanwhile, the harmonic response analysis and vibration fatigue coupling analysis were carried out, the analysis results were optimized, and the experimental device of the electromagnetic induction testing sensor was established. In addition, the experimental device with blood coagulation reagent was assorted to establish the standard point-of-care testing rapid blood coagulation detection curve, and to compare the testing curve with that of the imported point-of-care testing blood coagulation instrument. The results showed that the first-order natural frequency of the designed sensor was 102.35 Hz, the correlation between the designed sensor and the imported equipment was 0.996, and the testing repeatability of the designed sensor could reach 0.002. Therefore, the designed blood coagulation testing sensor based on electromagnetic induction had the characteristics of favorable elasticity and anti-fatigue, which could meet the accuracy requirements of clinical detection. Taken together, this study could provide the core technology for developing the point-of-care testing instrument for blood coagulation dynamic testing.

Point-of-care testing and INR within-subject variation in patients receiving a constant dose of vitamin K antagonist

2015 ◽  
Vol 114 (12) ◽  
pp. 1260-1267
Author(s):  
Joseph S. Biedermann ◽  
Marieke J. H. A. Kruip ◽  
A. M. H. P. van den Besselaar
Keyword(s):  
Blood Coagulation ◽  
Vitamin K ◽  
Whole Blood ◽  
Point Of Care ◽  
Vitamin K Antagonists ◽  
Professional Staff ◽  
Self Testing ◽  
Target Intensity ◽  
Constant Dose ◽  
Coaguchek Xs

SummaryMany patients treated with vitamin K antagonists (VKA) determine their INR using point-of-care (POC) whole blood coagulation monitors. The primary aim of the present study was to assess the INR within-subject variation in self-testing patients receiving a constant dose of VKA. The second aim of the study was to derive INR imprecision goals for whole blood coagulation monitors. Analytical performance goals for INR measurement can be derived from the average biological within-subject variation. Fifty-six Thrombosis Centres in the Netherlands were invited to select self-testing patients who were receiving a constant dose of either acenocoumarol or phenprocoumon for at least six consecutive INR measurements. In each patient, the coefficient of variation (CV) of INRs was calculated. One Thrombosis Centre selected regular patients being monitored with a POC device by professional staff. Sixteen Dutch Thrombosis Centres provided results for 322 selected patients, all using the CoaguChek XS. The median within-subject CV in patients receiving acenocoumarol (10.2 %) was significantly higher than the median CV in patients receiving phenprocoumon (8.6 %) (p = 0.001). The median CV in low-target intensity acenocoumarol self-testing patients (10.4 %) was similar to the median CV in regular patients monitored by professional staff (10.2 %). Desirable INR analytical imprecision goals for POC monitoring with CoaguChek XS in patients receiving either low-target intensity acenocoumarol or phenprocoumon were 5.1 % and 4.3 %, respectively. The approximate average value for the imprecision of the CoaguChek XS, i. e. 4 %, is in agreement with these goals.

scholarly journals Blood Coagulation Testing Smartphone Platform Using Quartz Crystal Microbalance Dissipation Method

Sensors ◽  
2018 ◽  
Vol 18 (9) ◽  
pp. 3073 ◽  
Author(s):  
Jia Yao ◽  
Bin Feng ◽  
Zhiqi Zhang ◽  
Chuanyu Li ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Quartz Crystal Microbalance ◽  
Quartz Crystal ◽  
Clinical Laboratory ◽  
Point Of Care ◽  
Dissipation Factor ◽  
Parylene C ◽  
Adhesive Surface ◽  
Self Testing ◽  
Coagulation Testing

Blood coagulation function monitoring is important for people who are receiving anticoagulation treatment and a portable device is needed by these patients for blood coagulation self-testing. In this paper, a novel smartphone based blood coagulation test platform was proposed. It was developed based on parylene-C coated quartz crystal microbalance (QCM) dissipation measuring and analysis. The parylene-C coating constructed a robust and adhesive surface for fibrin capturing. The dissipation factor was obtained by measuring the frequency response of the sensor. All measured data were sent to a smartphone via Bluetooth for dissipation calculation and blood coagulation results computation. Two major coagulation indexes, activated partial thromboplastin time (APTT) and prothrombin time (PT) were measured on this platform compared with results by a commercial hemostasis system in a clinical laboratory. The measurement results showed that the adjusted R-square (R2) value for APTT and PT measurements were 0.985 and 0.961 respectively. The QCM dissipation method for blood coagulation measurement was reliable and effective and the platform together with the QCM dissipation method was a promising solution for point of care blood coagulation testing.

Comprehensive Blood Coagulation Profiling in Patients Using iCoagLab: Comparison Against Thromboelastography

2020 ◽  
Vol 120 (07) ◽  
pp. 1116-1127 ◽  
Author(s):  
Markandey M. Tripathi ◽  
Diane M. Tshikudi ◽  
Zeinab Hajjarian ◽  
Dallas C. Hack ◽  
Elizabeth M. Van Cott ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Blood Coagulation ◽  
Whole Blood ◽  
Point Of Care ◽  
Bleeding Risk ◽  
Laser Speckle ◽  
Progression Rate ◽  
Accurate Identification ◽  
Blood Samples ◽  
Speckle Patterns

AbstractDelayed identification of coagulopathy and bleeding increases the risk of organ failure and death in hospitalized patients. Timely and accurate identification of impaired coagulation at the point-of-care can proactively identify bleeding risk and guide resuscitation, resulting in improved outcomes for patients. We test the accuracy of a novel optical coagulation sensing approach, termed iCoagLab, for comprehensive whole blood coagulation profiling and investigate its diagnostic accuracy in identifying patients at elevated bleeding risk. Whole blood samples from patients (N = 270) undergoing conventional coagulation testing were measured using the iCoagLab device. Recalcified and kaolin-activated blood samples were loaded in disposable cartridges and time-varying intensity fluctuation of laser speckle patterns were measured to quantify the clot viscoelastic modulus during coagulation. Coagulation parameters including the reaction time (R), clot progression time (K), clot progression rate (α), and maximum clot strength (MA) were derived from clot viscoelasticity traces and compared with mechanical thromboelastography (TEG). In all patients, a good correlation between iCoagLab- and TEG-derived parameters was observed (p < 0.001). Multivariate analysis showed that iCoagLab-derived parameters identified bleeding risk with sensitivity (94%) identical to, and diagnostic accuracy (89%) higher than TEG (87%). The diagnostic specificity of iCoagLab (77%) was significantly higher than TEG (69%). By rapidly and comprehensively permitting blood coagulation profiling the iCoagLab innovation is likely to advance the capability to identify patients with elevated risk for bleeding, with the ultimate goal of preventing life-threatening hemorrhage.

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