Rapid, Noninvasive Quantitative Determination of Acyclovir in Pharmaceutical Solid Dosage Forms through Their Poly(Vinyl Chloride) Blister Package by Solid-State Fourier Transform Raman Spectroscopy

2003 ◽  
Vol 57 (4) ◽  
pp. 407-412 ◽  
Author(s):  
Stavroula G. Skoulika ◽  
Constantinos A. Georgiou
Keyword(s):  
Raman Spectroscopy ◽  
Fourier Transform ◽  
Dosage Forms ◽  
Band Intensity ◽  
Solid Dosage Forms ◽  
Solid Dosage ◽  
Band Area ◽  
Poly Vinyl Chloride ◽  
Ft Raman

Fourier transform (FT) Raman spectroscopy based on band intensity or band area measurements was used for the quantitative determination of acyclovir in pharmaceutical solid dosage forms through their poly(vinyl chloride) blister package. Univariate calibration using the bands observed at 1690, 1630, 1574, 1482, 1181, 578, and 508 cm−1 was found to be sufficient for the analysis. Calibration curves were linear, the correlation coefficients being 0.997–0.9993 and 0.996–0.9991 for band intensity and band area measurements, respectively. Results obtained compare well, as indicated by the t-test, with those obtained by the current United States Pharmacopoeia (USP 24) and National Formulary (NF 19) method. Precision ranged from 0.7–4.5 and 0.4–4.0% RSD ( n = 3) for band intensity and band area measurements, respectively. The developed nondestructive FT-Raman method is rapid, simple, and can be used for the on-line, real-time monitoring of acyclovir formulation production lines.

Determination of Aspirin and Salicylic Acid by Reverse-Phase Liquid Chromatography

1987 ◽  
Vol 70 (6) ◽  
pp. 964-966
Author(s):  
Dorothy R Heidemann ◽  
Edward S Schulenberg ◽  
William H Smith
Keyword(s):  
Salicylic Acid ◽  
Dosage Forms ◽  
Solid Dosage Forms ◽  
Reverse Phase ◽  
Solid Dosage ◽  
Reverse Phase Liquid Chromatography ◽  
Sample Extraction ◽  
Phase Liquid ◽  
Phase Column

Abstract Buffered solid dosage forms containing aspirin, magnesium hydroxide, and aluminum hydroxide are blended with acidic ethanol to extract the aspirin and salicylic acid rapidly. The resulting preparation is then immediately injected onto a 4.6 mm x 3 cm 5 (im reverse-phase column. Aspirin and free salicylic acid are determined simultaneously. The run time is <2 min. The total time from the initiation of sample extraction to completion of the separation is <5 min.

Univariate and Multivariate Calibration for the Quantitative Determination of Methyl-Parathion in Pesticide Formulations by FT-Raman Spectroscopy

2000 ◽  
Vol 54 (5) ◽  
pp. 747-752 ◽  
Author(s):  
Stavroula G. Skoulika ◽  
Constantinos A. Georgiou
Keyword(s):  
Quantitative Determination ◽  
Methyl Parathion ◽  
Multivariate Calibration ◽  
Band Intensity ◽  
Calibration Data ◽  
Band Area ◽  
Pesticide Formulations ◽  
Relative Standard ◽  
Ft Raman

A Fourier transform (FT)-Raman method for the quantitative determination of methyl-parathion in pesticide formulations is described. The proposed method was applied to the analysis of formulations of methyl-parathion. Univariate and multivariate calibration were used and compared for quantitative analysis. Bands observed at 634, 661, 1113, 1348, and 1527 cm−1 were used for univariate calibration. Calibration curves were linear (correlation coefficients: 0.996–0.998 and 0.994–0.999 for band intensity and band area measurements, respectively) in the concentration range of 0.6–3.75 M for the 634, 661, and 1527 cm−1 bands; 0.05–3.75 M for the 1113 cm−1 band; and 0.1–3.75 M for the 1348 cm−1 band. Precision ranged from 0.5 to 5.2% and 0.1 to 6.8% relative standard deviation (RSD) ( n = 4) for band intensity and band area measurements, respectively. Spectra normalization against the 802 cm−1 cyclohexane band improved the long-term stability of calibration, allowing the use of calibration data acquired 30 days prior to analysis. The application of the method was extended through multivariate calibration by multiple linear regression using the 858 and 2952 cm−1 bands. Results obtained compare well with those obtained by the high-performance liquid chromatography (HPLC) reference method. The FT-Raman method developed is rapid, simple, and safe, as toxic samples are analyzed “as received” without sample pretreatment.

Determination of Methamphetamine and its Related Compounds Using Fourier Transform Raman Spectroscopy

1997 ◽  
Vol 51 (12) ◽  
pp. 1796-1799 ◽  
Author(s):  
Hitoshi Tsuchihashi ◽  
Munehiro Katagi ◽  
Mayumi Nishikawa ◽  
Michiaki Tatsuno ◽  
Hiroshi Nishioka ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Fourier Transform ◽  
Ephedrine Hydrochloride ◽  
Fourier Transform Raman Spectroscopy ◽  
Plastic Bag ◽  
Amphetamine Sulfate ◽  
Fourier Transform Raman ◽  
Related Compounds ◽  
Ft Raman

Fourier transform Raman spectroscopy (FT-Raman) is investigated as a simple and rapid method for the determination of the abused drug methamphetamine and its related compounds. Compounds can be reliably identified by using measurements made nondestructively and without the need for any sample preparation in around 1 min. The Raman spectrum of methamphetamine hydrochloride (MA) shows clear differences in spectra from a range of its related compounds such as amphetamine sulfate and ephedrine hydrochloride. These differences are adequate for spectral differentiation of the compounds. With the use of the FT-Raman technique, MA is also reliably identifiable to a detection limit of 1% (w/w) diluted in sodium chloride or water. FT-Raman spectra of MA were recorded through plastic packaging (polyethylene or polypropylene bags) typical of that used either by criminals for transportation or by law enforcement for containing and sealing evidence. Measurements could be made directly without removing the drug from the bag; excellent-quality spectra could be obtained with very little perturbation by the plastic bag.

Novel First Order Derivative UV Spectrophotometric Method for the Determination of Glimepiride in Solid Dosage Forms

2018 ◽  
Vol 8 (3) ◽  
Author(s):  
Santosh Karajgi . ◽  
Sunayana Mali ◽  
Ramaling Kotnal
Keyword(s):  
Dosage Forms ◽  
Order Derivative ◽  
Simultaneous Estimation ◽  
Drug Form ◽  
Solid Dosage Forms ◽  
First Order ◽  
Solid Dosage ◽  
Tablet Dosage ◽  
Guide Lines

Objective: An easy, perfect, specific and exact process has been studied for the simultaneous estimation of Glimepiride pure drug form as well as tablet dosage forms. Methods: A UV method for quantitative evaluation of Glimepiride by first order derivative peak detect method for determination in bulk as well as tablet dosage form is reported as there was a need to expand novel methods to analyze the drug. Results: Glimepiride has absorbance first derivative maxima at 225 nm in Methanol. Glimepiride follows Beer’s law in concentration range of 5-25µg/ml. The outcomes of the study were validated statistically and recovery studies were performed as per ICH guide lines. Conclusion: Thus the projected method can be applied competently for the estimation of Glimepiride in regular analysis in its dosage forms.

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