Measurement of Spatial Resolution and Sensitivity in Transmission and Backscattering Raman Spectroscopy of Opaque Samples: Impact on Pharmaceutical Quality Control and Raman Tomography

2010 ◽  
Vol 64 (5) ◽  
pp. 476-484 ◽  
Author(s):  
Neil Everall ◽  
Ian Priestnall ◽  
Paul Dallin ◽  
John Andrews ◽  
Ian Lewis ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Quality Control ◽  
Spatial Resolution ◽  
Pharmaceutical Quality

Submicron Simultaneous IR and Raman Spectroscopy (IR+Raman): Breakthrough Developments in Optical Photothermal IR (O-PTIR) Combined for Enhanced Failure Analysis

2019 ◽  
Author(s):  
Jay Anderson ◽  
Mustafa Kansiz ◽  
Michael Lo ◽  
Curtis Marcott
Keyword(s):  
Raman Spectroscopy ◽  
Failure Analysis ◽  
Data Quality ◽  
Raman Spectra ◽  
Spatial Resolution ◽  
Far Field ◽  
Field Mode ◽  
Microscopic Scale ◽  
Analytical Tools ◽  
Ir And Raman

Abstract Failure analysis of organics at the microscopic scale is an increasingly important requirement, with traditional analytical tools such as FTIR and Raman microscopy, having significant limitations in either spatial resolution or data quality. We introduce here a new method of obtaining Infrared microspectroscopic information, at the submicron level in reflection (far-field) mode, called Optical-Photothermal Infrared (O-PTIR) spectroscopy, that can also generate simultaneous Raman spectra, from the same spot, at the same time and with the same spatial resolution. This novel combination of these two correlative techniques can be considered to be complimentary and confirmatory, in which the IR confirms the Raman result and vice-versa, to yield more accurate and therefore more confident organic unknowns analysis.

System errors of manufacturers of medicines detected by conducting of state control in the area of circulation of medicines

2019 ◽  
Vol 2019 (5) ◽  
pp. 32-38
Author(s):  
Валентина Косенко ◽  
Valentina Kosenko ◽  
Алла Трапкова ◽  
Alla Trapkova ◽  
Светлана Тарасова ◽  
...  
Keyword(s):  
Quality Control ◽  
Quality Management ◽  
Management Systems ◽  
State Control ◽  
Quality Management Systems ◽  
Conducting State ◽  
Pharmaceutical Quality ◽  
State Quality ◽  
System Errors

The article conducts the analysis of system errors detected by Roszdravnadzor by conducting state quality control of circulating medicines, as well as weaknesses in pharmaceutical quality management systems of the manufacturers, that can influence the quality of manufactured drugs.

Aperture based Raman spectroscopy on SiGe film structures with high spatial resolution

2008 ◽  
Vol 39 (4) ◽  
pp. 435-438 ◽  
Author(s):  
A. Mai ◽  
L. Zhu ◽  
M. Hecker ◽  
J. Rinderknecht ◽  
C. Georgi ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Spatial Resolution ◽  
High Spatial Resolution

Optical Diagnostics of Microstructures Fabricated Using Quantum Well Intermixing

1999 ◽  
Vol 607 ◽  
Author(s):  
A. Saher Helmy ◽  
A.C. Bryce ◽  
C.N. Ironside ◽  
J.S. Aitchison ◽  
J.H. Marsh ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Quantum Well ◽  
Spatial Resolution ◽  
Optical Diagnostics ◽  
Complete Suppression ◽  
Quantum Well Intermixing ◽  
Spatially Resolved ◽  
Non Destructive ◽  
Insight Into ◽  
Free Vacancy

AbstractIn this paper we shall discuss techniques for accurate, non-destructive, optical characterisation of structures fabricated using quantum well intermixing (QWI). Spatially resolved photoluminescence and Raman spectroscopy were used to characterise the lateral bandgap profiles produced by impurity free vacancy disordering (IFVD) technology. Different features were used to examine the spatial resolution of the intermixing process. Features include 1:1 gratings as well as isolated stripes. From the measurements, the spatial selectivity of IFVD could be identified, and was found to be ∼4.5 μm, in contrast with the spatial resolution of the process of sputtering induced intermixing, which was found to be ∼2.5 μm. In addition, PL measurements on 1:1 gratings fabricated using IFVD show almost complete suppression of intermixing dielectric cap gratings with periods less than 10 microns. Finally, some insight into the limitations and merits of PL and Raman for the precision characterisation of QWI will be presented.

scholarly journals In situ Analytical Quality Control of chemotherapeutic solutions in infusion bags by Raman spectroscopy

Talanta ◽  
2021 ◽  
Vol 228 ◽  
pp. 122137
Author(s):  
Alaa A. Makki ◽  
Suha Elderderi ◽  
Victor Massot ◽  
Renaud Respaud ◽  
Hugh.J. Byrne ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Quality Control ◽  
Analytical Quality Control ◽  
Analytical Quality

Assessing the impact of automation in pharmaceutical quality control labs using a digital twin

2022 ◽  
Vol 62 ◽  
pp. 270-285
Author(s):  
Tiago Coito ◽  
Miguel S.E. Martins ◽  
Bernardo Firme ◽  
João Figueiredo ◽  
Susana M. Vieira ◽  
...  
Keyword(s):  
Quality Control ◽  
Digital Twin ◽  
Pharmaceutical Quality ◽  
The Impact

scholarly journals STEAD: A high-resolution daily gridded temperature dataset for Spain

2019 ◽  
Author(s):  
Roberto Serrano-Notivoli ◽  
Santiago Beguería ◽  
Martín De Luis
Keyword(s):  
Quality Control ◽  
Spatial Resolution ◽  
Minimum Temperature ◽  
Grid Point ◽  
Temporal Distribution ◽  
Original Data ◽  
Accurate Estimate ◽  
Absolute Temperature ◽  
Data Series ◽  
Absolute Maximum

Abstract. Using the full total of available 5520 observatories covering the whole territory of Spain, a daily gridded maximum and minimum temperature was built covering a period from 1901 to 2014 in peninsular Spain and 1971–2014 in Balearic and Canary Islands. A comprehensive quality control was applied to the original data and the gaps were filled on each day and location independently. Using the filled data series, a grid of 5 × 5 km spatial resolution was created by estimating daily temperatures and their corresponding uncertainties at each grid point. Four daily temperature indices were calculated to describe the spatial distribution of absolute maximum and minimum temperature, number of frost days and number of summer days in Spain. The southern plateau showed the maximum values of maximum absolute temperature and summer days, while the minimum absolute temperature and frost days reached their maximums at northern plateau. The use of all the available information, the complete quality control and the high spatial resolution of the grid allowed for an accurate estimate of temperature that represents a precise spatial and temporal distribution of daily temperatures in Spain. STEAD dataset is publicly available at http://dx.doi.org/10.20350/digitalCSIC/8622.

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