A Genome-Wide RNAi Screen in Caenorhabditis elegans Identifies the Nicotinic Acetylcholine Receptor Subunit ACR-7 as an Antipsychotic Drug Target

Antipsychotic Drug ◽

Drug Target ◽

Rnai Screen ◽

Receptor Subunit ◽

Nicotinic Acetylcholine ◽

Genome Wide ◽

A Genome

Faculty Opinions recommendation of Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1022312.254647 ◽

2004 ◽

Author(s):

Marina Picciotto

Keyword(s):

Acetylcholine Receptor ◽

Nicotine Withdrawal ◽

Receptor Subunit ◽

Functional characterization of a mutated chicken α 7 nicotinic acetylcholine receptor subunit with a leucine residue inserted in transmembrane domain 2

British Journal of Pharmacology ◽

10.1038/sj.bjp.0701866 ◽

1998 ◽

Vol 124 (4) ◽

pp. 747-755 ◽

Cited By ~ 2

Author(s):

Steven D Buckingham ◽

Charlotte Adcock ◽

Mark S P Sansom ◽

David B Sattelle ◽

Howard A Baylis

Keyword(s):

Acetylcholine Receptor ◽

Transmembrane Domain ◽

Functional Characterization ◽

Receptor Subunit ◽

Nicotinic Acetylcholine ◽

Leucine Residue

6-hydroxydopamine lesion of rat nigrostriatal dopaminergic neurons differentially affects nicotinic acetylcholine receptor subunit mRNA expression

Journal of Molecular Neuroscience ◽

10.1007/bf02761778 ◽

1998 ◽

Vol 10 (3) ◽

pp. 251-260 ◽

Cited By ~ 31

Author(s):

Kathryn J. Elliott ◽

Jay M. Jones ◽

Aida I. Sacaan ◽

G. Kenneth Lloyd ◽

Janis Corey-Naeve

Keyword(s):

Mrna Expression ◽

Acetylcholine Receptor ◽

Dopaminergic Neurons ◽

Receptor Subunit ◽

Nicotinic Acetylcholine ◽

Subunit Mrna ◽

6 Hydroxydopamine

Distinct contributions of nicotinic acetylcholine receptor subunit 4 and subunit 6 to the reinforcing effects of nicotine

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1103000108 ◽

2011 ◽

Vol 108 (18) ◽

pp. 7577-7582 ◽

Cited By ~ 106

Author(s):

R. Exley ◽

N. Maubourguet ◽

V. David ◽

R. Eddine ◽

A. Evrard ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Subunit ◽

Nicotinic Acetylcholine ◽

Reinforcing Effects

Targeted Deletion of the Mouse 2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors

Journal of Neuroscience ◽

10.1523/jneurosci.4731-12.2013 ◽

2013 ◽

Vol 33 (18) ◽

pp. 7728-7741 ◽

Cited By ~ 38

Author(s):

S. Lotfipour ◽

J. S. Byun ◽

P. Leach ◽

C. D. Fowler ◽

N. P. Murphy ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Subunit ◽

Subunit Gene ◽

Nicotinic Acetylcholine ◽

Targeted Deletion

Ultrastructural Distribution of the α7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus

Journal of Neuroscience ◽

10.1523/jneurosci.21-20-07993.2001 ◽

2001 ◽

Vol 21 (20) ◽

pp. 7993-8003 ◽

Cited By ~ 239

Author(s):

Ruth Fabian-Fine ◽

Paul Skehel ◽

Mick L. Errington ◽

Heather A. Davies ◽

Emanuele Sher ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Rat Hippocampus ◽

Receptor Subunit ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Receptors and the Treatment of Attentional and Cognitive Deficits in Neuropsychiatric Disorders: Focus on the α7 Nicotinic Acetylcholine Receptor as a Promising Drug Target for Schizophrenia

Central Nervous System Agents in Medicinal Chemistry ◽

10.2174/187152407783220797 ◽

2007 ◽

Vol 7 (4) ◽

pp. 269-288 ◽

Cited By ~ 6

Author(s):

Christian Chiamulera ◽

Guido Fumagalli

Keyword(s):

Acetylcholine Receptor ◽

Cognitive Deficits ◽

Drug Target ◽

Nicotinic Receptors ◽

Neuropsychiatric Disorders ◽

Candidate gene association studies of the α4 (CHRNA4) and β2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease

Neuroscience Letters ◽

10.1016/j.neulet.2004.01.016 ◽

2004 ◽

Vol 358 (2) ◽

pp. 142-146 ◽

Cited By ~ 28

Author(s):

Lynnette J. Cook ◽

Luk W. Ho ◽

Alison E. Taylor ◽

Carol Brayne ◽

John Grimley Evans ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Candidate Gene ◽

Acetylcholine Receptor ◽

Association Studies ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Receptor Subunit ◽

Nicotinic Acetylcholine ◽

Gene Association ◽

Candidate Gene Association

Nicotine-induced Ca2+ signaling and down-regulation of nicotinic acetylcholine receptor subunit expression in the CEM human leukemic T-cell line

Life Sciences ◽

10.1016/s0024-3205(03)00077-8 ◽

2003 ◽

Vol 72 (18-19) ◽

pp. 2155-2158 ◽

Cited By ~ 45

Author(s):

Reika Kimura ◽

Naoki Ushiyama ◽

Takeshi Fujii ◽

Koichiro Kawashima

Keyword(s):

T Cell ◽

Cell Line ◽

Acetylcholine Receptor ◽

Receptor Subunit ◽

Down Regulation ◽

Nicotinic Acetylcholine ◽

Subunit Expression

Expression of nicotinic acetylcholine receptor subunits from parasitic nematodes in Caenorhabditis elegans

Molecular and Biochemical Parasitology ◽

10.1016/j.molbiopara.2015.12.006 ◽

2015 ◽

Vol 204 (1) ◽

pp. 44-50 ◽

Cited By ~ 9

Author(s):

Megan A. Sloan ◽

Barbara J. Reaves ◽

Mary J. Maclean ◽

Bob E. Storey ◽

Adrian J. Wolstenholme

Keyword(s):

Caenorhabditis Elegans ◽

Acetylcholine Receptor ◽

Parasitic Nematodes ◽