scholarly journals Genetics of white color and iridophoroma in “Lemon Frost” leopard geckos

PLoS Genetics ◽  
2021 ◽  
Vol 17 (6) ◽  
pp. e1009580
Author(s):  
Longhua Guo ◽  
Joshua Bloom ◽  
Steve Sykes ◽  
Elaine Huang ◽  
Zain Kashif ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Development ◽  
Genetic System ◽  
Homozygosity Mapping ◽  
Biological Traits ◽  
Eublepharis Macularius ◽  
Leopard Gecko ◽  
Strong Candidate ◽  
Coloration Patterns ◽  
Close Relatives

The squamates (lizards and snakes) are close relatives of birds and mammals, with more than 10,000 described species that display extensive variation in a number of important biological traits, including coloration, venom production, and regeneration. Due to a lack of genomic tools, few genetic studies in squamates have been carried out. The leopard gecko, Eublepharis macularius, is a popular companion animal, and displays a variety of coloration patterns. We took advantage of a large breeding colony and used linkage analysis, synteny, and homozygosity mapping to investigate a spontaneous semi-dominant mutation, “Lemon Frost”, that produces white coloration and causes skin tumors (iridophoroma). We localized the mutation to a single locus which contains a strong candidate gene, SPINT1, a tumor suppressor implicated in human skin cutaneous melanoma (SKCM) and over-proliferation of epithelial cells in mice and zebrafish. Our work establishes the leopard gecko as a tractable genetic system and suggests that a tumor suppressor in melanocytes in humans can also suppress tumor development in iridophores in lizards.

scholarly journals Genetics of white color and iridophoroma in "Lemon Frost" leopard geckos

2020 ◽  
Author(s):  
Longhua Guo ◽  
Joshua S Bloom ◽  
Steve Sykes ◽  
Elaine Huang ◽  
Zain Kashif ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Development ◽  
Genetic System ◽  
Homozygosity Mapping ◽  
Evolutionary Mechanisms ◽  
Eublepharis Macularius ◽  
Leopard Gecko ◽  
Strong Candidate ◽  
Coloration Patterns ◽  
Strong Candidate Gene

Coloration patterns promote survival and reproductive success in the animal kingdom. Despite their importance, wide gaps exist in our understanding of the genetic and evolutionary mechanisms that underpin them. The leopard gecko, Eublepharis macularius, is a popular companion animal, and displays a variety of coloration patterns. We investigated a spontaneous semi-dominant mutation, known as "Lemon Frost", that causes extensive white color in leopard gecko skin. Although "Lemon Frost" individuals are aesthetically appealing, more than 80% of them develop tumors of white color (i.e., iridophoroma) 0.5 to 5 years after birth. To identify the gene that regulates white color and is likely also responsible for the iridophoroma, we genotyped 220 animals, including 33 homozygous mutants, with short-read sequencing. We used synteny, linkage analysis and homozygosity mapping to localize the mutation to a strong candidate gene, SPINT1, a tumor suppressor previously implicated in human skin cutaneous melanoma (SKCM) as well as in over-proliferation of epithelial cells in mice and zebrafish. Our work establishes the leopard gecko as a tractable genetic system and suggests that a tumor suppressor in melanocytes in humans can also suppress tumor development in iridophores in lizards.

scholarly journals Draft genome of the leopard gecko, Eublepharis macularius

GigaScience ◽  
2016 ◽  
Vol 5 (1) ◽  
Author(s):  
Zijun Xiong ◽  
Fang Li ◽  
Qiye Li ◽  
Long Zhou ◽  
Tony Gamble ◽  
...  
Keyword(s):  
Draft Genome ◽  
Eublepharis Macularius ◽  
Leopard Gecko

Genetic Events Responsible for Colorectal Tumorigenesis: Achievements and Challenges

1993 ◽  
Vol 79 (4) ◽  
pp. 235-243 ◽  
Author(s):  
Boris Kopnin
Keyword(s):  
Tumor Suppressor ◽  
Tumor Development ◽  
Suppressor Gene ◽  
Colorectal Carcinogenesis ◽  
Genetic Changes ◽  
Colorectal Tumorigenesis ◽  
Ras Genes ◽  
Carcinoma Cell Lines ◽  
Kinase C ◽  
Multistep Process

Colorectal carcinogenesis is a multistep process that is accompanied by accumulation of changes in proto-oncogenes and tumor-suppressor genes. APC/MCC, RAS, DCC, p53 mutations and/or allelic losses, hyperexpression of c-MYC and RB genes, as well as other genomic alterations appear at characteristic stages of tumor development and are observed in most neoplasms. However, consideration of each of these abnormalities leaves many unanswered questions. The striking data on recurrent amplification of the RB tumor-suppressor gene as well as suppressive activities of protein kinase C and activated RAS genes, at least in some colon carcinoma cell lines, suggest the unusual effects of some signalling pathways in colonic epithelial cells. The results obtained to date indicate that distinct sets of genetic changes may underlie the development of colorectal tumors.

Colonic adenocarcinoma in a leopard gecko (Eublepharis macularius)

2005 ◽  
Vol 157 (10) ◽  
pp. 294-295 ◽  
Author(s):  
J. C. Patterson-Kane ◽  
S. P. Redrobe
Keyword(s):  
Colonic Adenocarcinoma ◽  
Eublepharis Macularius ◽  
Leopard Gecko

scholarly journals LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Qiuhui Li ◽  
Bigang Liu ◽  
Hsueh-Ping Chao ◽  
Yibing Ji ◽  
Yue Lu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Development ◽  
Dependent Manner ◽  
Oncogenic Signaling ◽  
Transgenic Expression ◽  
Functional Studies ◽  
Castration Resistant ◽  
A Cell ◽  
Xenograft Models

AbstractLRIG1 has been reported to be a tumor suppressor in gastrointestinal tract and epidermis. However, little is known about the expression, regulation and biological functions of LRIG1 in prostate cancer (PCa). We find that LRIG1 is overexpressed in PCa, but its expression correlates with better patient survival. Functional studies reveal strong tumor-suppressive functions of LRIG1 in both AR+ and AR− xenograft models, and transgenic expression of LRIG1 inhibits tumor development in Hi-Myc and TRAMP models. LRIG1 also inhibits castration-resistant PCa and exhibits therapeutic efficacy in pre-established tumors. We further show that 1) AR directly transactivates LRIG1 through binding to several AR-binding sites in LRIG1 locus, and 2) LRIG1 dampens ERBB expression in a cell type-dependent manner and inhibits ERBB2-driven tumor growth. Collectively, our study indicates that LRIG1 represents a pleiotropic AR-regulated feedback tumor suppressor that functions to restrict oncogenic signaling from AR, Myc, ERBBs, and, likely, other oncogenic drivers.

Ontogenetic allometry of the digital rays of the leopard gecko (Gekkota: Eublepharidae;Eublepharis macularius)

2017 ◽  
Vol 99 (4) ◽  
pp. 331-356 ◽  
Author(s):  
George Lawrence Powell ◽  
Geoffrey J. Osgood ◽  
Anthony P. Russell
Keyword(s):  
Eublepharis Macularius ◽  
Leopard Gecko ◽  
Ontogenetic Allometry

scholarly journals The Cell Death Inhibitor ARC Is Induced in a Tissue-Specific Manner by Deletion of the Tumor Suppressor Gene Men1, but Not Required for Tumor Development and Growth

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0145792 ◽  
Author(s):  
Wendy M. McKimpson ◽  
Ziqiang Yuan ◽  
Min Zheng ◽  
Judy S. Crabtree ◽  
Steven K. Libutti ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Tumor Development ◽  
Suppressor Gene ◽  
Tissue Specific ◽  
Specific Manner
Sign in / Sign up

Export Citation Format

Share Document