scholarly journals Clinical Survey of Dengue Virus Circulation in the Republic of Djibouti between 2011 and 2014 Identifies Serotype 3 Epidemic and Recommends Clinical Diagnosis Guidelines for Resource Limited Settings

2016 ◽  
Vol 10 (6) ◽  
pp. e0004755 ◽  
Author(s):  
Erwan Le Gonidec ◽  
Marianne Maquart ◽  
Sandrine Duron ◽  
Hélène Savini ◽  
Geraldine Cazajous ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Clinical Diagnosis ◽  
Resource Limited Settings ◽  
Resource Limited ◽  
Clinical Survey ◽  
The Republic

A case of primary varicella meningoencephalitis in the absence of cutaneous lesions in a 4-month-old infant

2021 ◽  
pp. 004947552110561
Author(s):  
Vinod Kumar Palaparthy ◽  
Ruth Tigga
Keyword(s):  
Clinical Diagnosis ◽  
Cost Effective ◽  
Varicella Infection ◽  
Diagnostic Challenge ◽  
Cutaneous Lesions ◽  
Resource Limited Settings ◽  
Resource Limited ◽  
Definitive Therapy ◽  
History Of ◽  
Dna Pcr

Primary varicella infection has typical cutaneous lesions which aid in clinical diagnosis. Infants with transplacental transfer of varicella antibody can have varied cutaneous lesions. We report a 4-month-old infant with primary varicella meningoencephalitis without cutaneous lesions whose mother had no history of varicella during antenatal or post-natal period. Diagnosis was made possible by CSF DNA PCR. Infants with encephalitis pose diagnostic challenge to clinicians in resource limited settings. Varicella encephalitis is one such aetiology for which definitive therapy with Acyclovir is available. CSF PCR is the definitive and cost-effective test for the diagnosis varicella encephalitis. In children with meningoencephalitis it is prudent to add Acyclovir empirically pending CSF viral PCR results.

Vaccine Supply Chains in Resource-Limited Settings: Mitigating Rainy Season Disruptions

2020 ◽  
Author(s):  
Kim De Boeck ◽  
Catherine Decouttere ◽  
Jónas Oddur Jónasson ◽  
Nico Vandaele
Keyword(s):  
Supply Chains ◽  
Rainy Season ◽  
Resource Limited Settings ◽  
Resource Limited

scholarly journals Validation of a point-of-care rapid diagnostic test for hepatitis C for use in resource-limited settings

2019 ◽  
Vol 11 (4) ◽  
pp. 314-315
Author(s):  
James S Leathers ◽  
Maria Belen Pisano ◽  
Viviana Re ◽  
Gertine van Oord ◽  
Amir Sultan ◽  
...  
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Rapid Diagnosis ◽  
Direct Acting Antivirals ◽  
Resource Limited Settings ◽  
Rapid Diagnosis Test ◽  
Resource Limited ◽  
Specificity And Sensitivity ◽  
Hcv Screening ◽  
Direct Acting

Abstract Background Treatment of HCV with direct-acting antivirals has enabled the discussion of HCV eradication worldwide. Envisioning this aim requires implementation of mass screening in resource-limited areas, usually constrained by testing costs. Methods We validated a low-cost, rapid diagnosis test (RDT) for HCV in three different continents in 141 individuals. Results The HCV RDT showed 100% specificity and sensitivity across different samples regardless of genotype or viral load (in samples with such information, 90%). Conclusions The HCV test validated in this study can allow for HCV screening in areas of need when properly used.

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