scholarly journals Lysate of Probiotic Lactobacillus casei DN-114 001 Ameliorates Colitis by Strengthening the Gut Barrier Function and Changing the Gut Microenvironment

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27961 ◽  
Author(s):  
Zuzana Zakostelska ◽  
Miloslav Kverka ◽  
Klara Klimesova ◽  
Pavel Rossmann ◽  
Jakub Mrazek ◽  
...  
Keyword(s):  
Barrier Function ◽  
Lactobacillus Casei ◽  
Gut Barrier ◽  
Gut Barrier Function ◽  
Probiotic Lactobacillus

scholarly journals Centenarian-Sourced Lactobacillus casei Combined with Dietary Fiber Complex Ameliorates Brain and Gut Function in Aged Mice

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 324
Author(s):  
Minhong Ren ◽  
He Li ◽  
Zhen Fu ◽  
Quanyang Li
Keyword(s):  
Dietary Fiber ◽  
Barrier Function ◽  
Lactobacillus Casei ◽  
Dietary Intervention ◽  
Short Chain Fatty Acids ◽  
Gut Barrier ◽  
Aged Mice ◽  
Gut Barrier Function ◽  
Age Related ◽  
Gut Function

Dietary intervention could modulate age-related neurological disorders via the gut–brain axis. The potential roles of a probiotic and the dietary fiber complex (DFC) on brain and gut function in aged mice were investigated in this study. Lactobacillus casei LTL1361 and DFC were orally administrated for 12 weeks, and the learning and memory ability, as well as the oxidative parameters, inflammatory markers, gut barrier function and microbial metabolite short-chain fatty acids (SCFAs), were investigated. LTL1361 and DFC supplementation ameliorated cognitive ability, attenuated oxidative stress in brain and inflammation in serum and colon, ameliorated gut barrier function, and increased the SCFA concentrations and gene expression of SCFA receptors. The protective effect was more significantly enhanced in aged mice treated with the combination of LTL1361 and DFC than treated with LTL1361 or DFC alone. These results could be associated with the protected morphology of pyramidal nerve cells in hippocampus of mice brain and the downregulation of apoptosis marker caspase-3 in brain and upregulation of tight junction proteins in small intestine and colon. The results indicated that Lactobacillus casei LTL1361 and DFC alleviated age-related cognitive impairment, as well as protected brain and gut function. Lactobacillus casei LTL1361 and DFC might be used as novel and promising antiaging agents in human.

Bofutsushosan Improves Gut Barrier Function with a Bloom of Akkermansia Muciniphila and Improves Glucose Metabolism in Diet-Induced Obese Mice

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1990-P ◽  
Author(s):  
SHIHO FUJISAKA ◽  
ISAO USUI ◽  
ALLAH NAWAZ ◽  
YOSHIKO IGARASHI ◽  
TOMONOBU KADO ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Barrier Function ◽  
Obese Mice ◽  
Gut Barrier ◽  
Akkermansia Muciniphila ◽  
Gut Barrier Function

scholarly journals The Mucus Layer is Critical in Protecting Against Ischemia-Reperfusion-Mediated Gut Injury and in the Restitution of Gut Barrier Function

Shock ◽  
2011 ◽  
Vol 35 (3) ◽  
pp. 275-281 ◽  
Author(s):  
Xiaofa Qin ◽  
Sharvil U. Sheth ◽  
Susan M. Sharpe ◽  
Wei Dong ◽  
Qi Lu ◽  
...  
Keyword(s):  
Barrier Function ◽  
Ischemia Reperfusion ◽  
Mucus Layer ◽  
Gut Barrier ◽  
Gut Barrier Function

Lycium ruthenicum diet alters the gut microbiota and partially enhances gut barrier function in male C57BL/6 mice

2019 ◽  
Vol 52 ◽  
pp. 516-528 ◽  
Author(s):  
Baoming Tian ◽  
Jianhua Zhao ◽  
Wei An ◽  
Jiawei Zhang ◽  
Xin Cao ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Barrier Function ◽  
Gut Barrier ◽  
Gut Barrier Function ◽  
Lycium Ruthenicum

scholarly journals Clinical Analysis of Gut Barrier Dysfunction in Patients with Advanced Colorectal Cancer Undergoing Cytoreductive Surgery and HIPEC

2021 ◽  
Author(s):  
Le lai Ping ◽  
Jiang xu Mian ◽  
Chen Wei
Keyword(s):  
Colorectal Cancer ◽  
Cytoreductive Surgery ◽  
Barrier Function ◽  
Intraperitoneal Injection ◽  
Advanced Colorectal Cancer ◽  
Patient Characteristics ◽  
Barrier Dysfunction ◽  
Large Area ◽  
Gut Barrier ◽  
Gut Barrier Function

Abstract Introduction: Hyperthermic intraperitoneal chemotherapy combinedwith cytoreductive surgery is a preferred treatment option for advanced colorectal cancer patients. However, little is known whether the HIPEC can cause the damage of gut barrier function.Methods: A total of 123 patients underwent surgical resection for advanced CRC. Sixty-five patients were treated HIPEC after cytoreductive surgery whereas 58 patients underwent surgery only. Gut barrier function were evaluated using the expression of serum DAO/D-la/ET on D1/D5/D10 after surgery. Both groups were compared for patient characteristics, perioperative data and gut barrier function. Moreover, rats received intraperitoneal injection of retetrexed to observe possible changes of colonic structure under optical microscope.Results: Both groups were comparable with respect to general patient characteristics and post-operative complications. The HIPEC+CRS group was associated with a higher postoperative serum level of DAO/D-la on D1/D5 (p < 0.05) and ET on D5 after surgery (p < 0.05) than that of the surgery only group. Ten days after surgery showed no statistical difference between the 2 groups (p > 0.05).A large area structure disorder, epithelial necrosis, glandular deformation and a large number of lymphocytes infiltration was found in the lamina propria in animals received intraperitoneal injection of retetrexed.Conclusion: In this study, CRS combined with HIPEC does have but only an irreversible impact on gut barrier for advanced CRC patients.

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