Integrated Ratio of Metastatic to Examined Lymph Nodes and Number of Metastatic Lymph Nodes into the AJCC Staging System for Colon Cancer

Aim: To build a prognostic nomogram based on log odds of positive lymph nodes for patients with gastric carcinoma (GC) after resection, and to compare the predictive performance with the American Joint Committee on Cancer (AJCC) staging system and lymph node ratio (LNR). Methods: Multivariate analyses were performed to identify the independent variables for cancer-specific survival (CSS). A nomogram was constructed based on independent clinicopathological factors. Results: The C-indices for predicting CSS were 0.674 in development cohort and 0.647 in validation cohort, which were higher than that of the AJCC staging system and LNR. Conclusion: The nomogram was more accurate than the AJCC staging system and LNR for predicting CSS in patients undergoing resection for GC.

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Significance of Histologic Type of Primary Lesion and Metastatic Lymph Nodes as a Prognostic Factor in Stage III Colon Cancer

Diseases of the Colon & Rectum ◽

10.1007/s10350-006-0531-4 ◽

2006 ◽

Vol 49 (7) ◽

pp. 982-992 ◽

Cited By ~ 7

Author(s):

Takeo Mori ◽

Teruyuki Hirota ◽

Yasuo Ohashi ◽

Susumu Kodaira

Keyword(s):

Colon Cancer ◽

Prognostic Factor ◽

Lymph Nodes ◽

Primary Lesion ◽

Stage Iii ◽

Histologic Type ◽

Metastatic Lymph Nodes ◽

Stage Iii Colon Cancer ◽

Metastatic Lymph

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Can the Tumor Deposits Be Counted as Metastatic Lymph Nodes in the UICC TNM Staging System for Colorectal Cancer?

PLoS ONE ◽

10.1371/journal.pone.0034087 ◽

2012 ◽

Vol 7 (3) ◽

pp. e34087 ◽

Cited By ~ 29

Author(s):

Yong-Xi Song ◽

Peng Gao ◽

Zhen-Ning Wang ◽

Ji-Wang Liang ◽

Zhe Sun ◽

...

Keyword(s):

Colorectal Cancer ◽

Lymph Nodes ◽

Staging System ◽

Tnm Staging ◽

Metastatic Lymph Nodes ◽

Metastatic Lymph ◽

Tnm Staging System

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The feasibility and safety of complete laparoscopic extended right hemicolectomy with preserving the ileocecal junction in right-transverse colon cancer

10.21203/rs.3.rs-27753/v1 ◽

2020 ◽

Author(s):

Hao Su ◽

Hongliang Wu ◽

Bing Mu ◽

Mandula Bao ◽

Shou Luo ◽

...

Keyword(s):

Colon Cancer ◽

Lymph Nodes ◽

Transverse Colon ◽

Operation Time ◽

Right Hemicolectomy ◽

Control Group ◽

Transverse Colon Cancer ◽

Metastatic Lymph Nodes ◽

Ileocecal Junction ◽

Metastatic Lymph

Abstract Background: To evaluate the feasibility and safety of a new surgical method, complete laparoscopic extended right hemicolectomy with preserving the ileocecal junction in right-transverse colon cancer.Methods: We retrospectively analyzed and compared the data of consecutive patients with right-transverse colon cancer who underwent complete laparoscopic extended right hemicolectomy with preserving the ileocecal junction (n=23) and conventional complete laparoscopic extended right hemicolectomy (n=34) in our hospital between October 2017 to May 2019, respectively.Results: The overall operation time of the ileocecal junction-preserved group was significantly shorter than that of the control group (p=0.024). There was no difference in the number of harvested lymph nodes, metastatic lymph nodes and rate of metastatic lymph nodes (p＞0.05). The ileocecal junction-preserved group showed shorter time of first flatus, lower frequency of postoperative diarrhea and shorter duration of postoperative hospitalization. Furthermore, it also showed that the defecation frequency was lower in the ileocecal junction-preserved group than control group on the 1st, 3rd and 6th month (p＜0.05), and the number of patients who defecated at night or defecated four times or more a day were less in the ileocecal junction-preserved group than control group on the 1st month (p＜0.05).Conclusion: The complete laparoscopic extended right hemicolectomy with preserving the ileocecal junction promises as a safe and feasible surgical procedure for right-transverse colon cancer, associated with earlier recovery of bowel function, shorter operation time and similar pathological outcomes when compared to the conventional laparoscopic procedure.

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A rapid, sensitive, reproducible and cost-effective method for mutation profiling of colon cancer and metastatic lymph nodes

BMC Cancer ◽

10.1186/1471-2407-10-101 ◽

2010 ◽

Vol 10 (1) ◽

Cited By ~ 91

Author(s):

Debora Fumagalli ◽

Patrick G Gavin ◽

Yusuke Taniyama ◽

Seung-Il Kim ◽

Hyun-Joo Choi ◽

...

Keyword(s):

Colon Cancer ◽

Lymph Nodes ◽

Cost Effective ◽

Metastatic Lymph Nodes ◽

Metastatic Lymph ◽

Cost Effective Method ◽

Mutation Profiling

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Fluorescence Diagnosis of Metastatic Lymph Nodes Using 5-Aminolevulinic Acid (5-ALA) in a Mouse Model of Colon Cancer

Journal of Surgical Research ◽

10.1016/j.jss.2011.10.031 ◽

2012 ◽

Vol 176 (2) ◽

pp. 430-436 ◽

Cited By ~ 10

Author(s):

Shigeru Kato ◽

Junichiro Kawamura ◽

Kenji Kawada ◽

Suguru Hasegawa ◽

Yoshiharu Sakai

Keyword(s):

Colon Cancer ◽

Mouse Model ◽

Lymph Nodes ◽

Aminolevulinic Acid ◽

Fluorescence Diagnosis ◽

Metastatic Lymph Nodes ◽

Metastatic Lymph

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Nomogram for predicting the survival of gastric adenocarcinoma patients who receive surgery and chemotherapy

BMC Cancer ◽

10.1186/s12885-019-6495-2 ◽

2020 ◽

Vol 20 (1) ◽

Cited By ~ 4

Author(s):

Chao-Yang Wang ◽

Jin Yang ◽

Hao Zi ◽

Zhong-Li Zheng ◽

Bing-Hui Li ◽

...

Keyword(s):

Lymph Nodes ◽

Gastric Adenocarcinoma ◽

Clinical Decision Making ◽

External Validation ◽

Staging System ◽

Training Set ◽

Regional Lymph Nodes ◽

Ajcc Staging System ◽

Validation Set ◽

Ajcc Staging

Abstract Background Surgery is the only way to cure gastric adenocarcinoma (GAC), and chemotherapy is the basic adjuvant management for GAC. A significant prognostic nomogram for predicting the respective disease-specific survival (DSS) rates of GAC patients who receive surgery and chemotherapy has not been established. Objective We were planning to establish a survival nomogram model for GAC patients who receive surgery and chemotherapy. Methods We identified 5764 GAC patients who had received surgery and chemotherapy from the record of Surveillance, Epidemiology, and End Results (SEER) database. About 70% (n = 4034) of the chosen GAC patients were randomly assigned to the training set, and the rest of the included ones (n = 1729) were assigned to the external validation set. A prognostic nomogram was constructed by the training set and the predictive accuracy of it was validated by the validation set. Results Based on the outcome of a multivariate analysis of candidate factors, a nomogram was developed that encompassed age at diagnosis, number of regional lymph nodes examined after surgery, number of positive regional lymph nodes, sex, race, grade, derived AJCC stage, summary stage, and radiotherapy status. The C-index (Harrell’s concordance index) of the nomogram model was some larger than that of the traditional seventh AJCC staging system (0.707 vs 0.661). Calibration plots of the constructed nomogram displayed that the probability of DSS commendably accord with the survival rate. Integrated discrimination improvement (IDI) revealed obvious increase and categorical net reclassification improvement (NRI) showed visible enhancement. IDI for 3-, 5- and 10- year DSS were 0.058, 0.059 and 0.058, respectively (P > 0.05), and NRI for 3-, 5- and 10- year DSS were 0.380 (95% CI = 0.316–0.470), 0.407 (95% CI = 0.350–0.505), and 0.413 (95% CI = 0.336–0.519), respectively. Decision curve analysis (DCA) proved that the constructed nomogram was preferable to the AJCC staging system. Conclusion The constructed nomogram supplies more credible DSS predictions for GAC patients who receive surgery and chemotherapy in the general population. According to validation, the new nomogram will be beneficial in facilitating individualized survival predictions and useful when performing clinical decision-making for GAC patients who receive surgery and chemotherapy.

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Nomogram for predicting the survival of gastric adenocarcinoma patients who receive surgery and chemotherapy

10.21203/rs.2.10550/v2 ◽

2019 ◽

Author(s):

Chao-Yang Wang ◽

Jin Yang ◽

Hao Zi ◽

Zhong-Li Zheng ◽

Bing-Hui Li ◽

...

Keyword(s):

Lymph Nodes ◽

Gastric Adenocarcinoma ◽

Clinical Decision Making ◽

External Validation ◽

Staging System ◽

Training Set ◽

Regional Lymph Nodes ◽

Ajcc Staging System ◽

Validation Set ◽

Ajcc Staging

Abstract Background: Surgery is the only way to cure gastric adenocarcinoma (GAC), and chemotherapy is the basic adjuvant management for GAC. A prognostic model for predicting the individual disease-specific survival (DSS) rates of GAC patients who receive surgery and chemotherapy has not been established. Objective: We aimed to establish a survival nomogram for GAC patients who receive surgery and chemotherapy. Methods: We identified 5764 GAC patients who had received surgery and chemotherapy from the SEER (Surveillance, Epidemiology, and End Results) database. Approximately 80% (n=4034) of the included patients were randomly assigned to the training set, and the remaining patients (n=1729) were assigned to the external validation set. Nomogram was established by the training set and validated by the validation set. Results: Based on the results of a multivariate analysis, a nomogram was developed that encompassed age at diagnosis, number of regional lymph nodes examined, number of positive regional lymph nodes, sex, race, grade, derived AJCC stage, summary stage, and radiotherapy status. The C-index (Harrell’s concordance index) of the model was higher than that of the traditional seventh AJCC staging system (0.707 vs 0.661). Calibration plots of the nomogram showed that the probability of DSS optimally corresponded to the survival rate. Integrated discrimination improvement (IDI) and categorical net reclassification improvement (NRI) showed visible improvement. IDI for 3-, 5- and 10- year DSS were 0.058, 0.059 and 0.058, respectively (P>0.05), and NRI for 3-, 5- and 10- year DSS were 0.380 (95% CI=0.316–0.470), 0.407 (95% CI=0.350–0.505), and 0.413 (95% CI=0.336–0.519), respectively. Decision curve analysis supported that the constructed nomogram was superior to the AJCC staging system. Conclusion: The proposed nomogram provides more-reliable DSS predictions for GAC patients who receive surgery and chemotherapy in the general population. According to validation, the new nomogram will be beneficial in facilitating individualized survival predictions and useful when performing clinical decision-making for GAC patients who receive surgery and chemotherapy.

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Validation of the 8th Edition of the American Joint Committee on Cancer Staging System for Gallbladder Cancer and Implications for the Follow-up of Patients without Node Dissection

Cancer Research and Treatment ◽

10.4143/crt.2019.271 ◽

2020 ◽

Vol 52 (2) ◽

pp. 455-468

Author(s):

You-Na Sung ◽

Minjeong Song ◽

Jae Hoon Lee ◽

Ki Byung Song ◽

Dae Wook Hwang ◽

...

Keyword(s):

Lymph Nodes ◽

Gallbladder Cancer ◽

Staging System ◽

Cancer Staging ◽

Significant Survival ◽

Nodal Dissection ◽

Ajcc Staging System ◽

Ajcc Staging ◽

Survival Differences ◽

8Th Edition

PurposeThe 8th edition of gallbladder cancer staging in the American Joint Committee on Cancer (AJCC) staging system changed the T and N categories.Materials and MethodsIn order to validate the new staging system, a total of 348 surgically resected gallbladder cancers were grouped based on the 8th edition of the T and N categories and compared with patients’ survival.ResultsSignificant differences were noted between T1b-T2a (p=0.003) and T2b-T3 (p < 0.001) tumors, but not between Tis-T1a, T1a-T1b, and T2a-T2b tumors. However, significant survival differences were observed both by the overall and pair-wise (T1-T2, T2-T3) comparisons (all, p < 0.001) without dividing T1/T2 subcategories. When cases with ≥ 6 examined lymph nodes were evaluated, significant survival differences were observed among the entire comparison (p < 0.001) and pair-wise comparisons of N0-N1 (p=0.001) and N1-N2 (p=0.039) lesions. When cases without nodal dissection (NX) were additionally compared, significant survival differences were observed between patients with N0-NX (p=0.001) and NX-N1 (p < 0.001) lesions.ConclusionThe T category in the 8th edition of the AJCC staging system did not completely stratify the prognosis of patients with gallbladder cancer. Modification by eliminating T subcategories can better stratify the prognosis. In contrast, the N category clearly determines patients’ survival with ≥ 6 examined lymph nodes. The survival time in patients of gallbladder cancers without nodal dissection is between N0 and N1 cases. Therefore, close postoperative followed up is recommended for those patients.

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