scholarly journals Genetic Control of Canine Leishmaniasis: Genome-Wide Association Study and Genomic Selection Analysis

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e35349 ◽  
Author(s):  
Javier Quilez ◽  
Verónica Martínez ◽  
John A. Woolliams ◽  
Armand Sanchez ◽  
Ricardo Pong-Wong ◽  
...  
Keyword(s):  
Association Study ◽  
Genomic Selection ◽  
Genetic Control ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Canine Leishmaniasis ◽  
Selection Analysis ◽  
Genome Wide

scholarly journals Genome-wide association study and genomic selection for plant height, maturity, seed weight, and yield in soybean

2019 ◽  
Author(s):  
Waltram Ravelombola ◽  
Jun Qin ◽  
Ainong Shi ◽  
Fengmin Wang ◽  
Yan Feng ◽  
...  
Keyword(s):  
Association Study ◽  
Genomic Selection ◽  
Candidate Genes ◽  
Plant Height ◽  
Seed Weight ◽  
Genome Wide Association Study ◽  
Agronomic Traits ◽  
Snp Markers ◽  
Genome Wide Association ◽  
Genome Wide

Abstract Background Soybean [ Glycine max (L.) Merr.] is a legume of great interest worldwide. Enhancing genetic gain for agronomic traits via molecular approaches has been long considered as the main task for soybean breeders and geneticists. The objectives of this study were to evaluate maturity, plant height, seed weight, and yield in a diverse soybean accession panel, to conduct a genome-wide association study (GWAS) for these traits and identify SNP markers associated with the four traits, and to assess genomic selection (GS) accuracy. Results A total of 250 soybean accessions were evaluated for maturity, plant height, seed weight, and yield over three years. This panel was genotyped with a total of 10,259 high quality SNPs postulated from genotyping by sequencing (GBS). GWAS was performed using a Bayesian Information and Linkage Disequilibrium Iteratively Nested Keyway (BLINK) model, and GS was evaluated using a ridge regression best linear unbiased predictor (rrBLUP) model. The results revealed that a total of 20, 31, 37, 31, and 23 SNPs were significantly associated with the average 3-year data for maturity, plant height, seed weight, and yield, respectively; some significant SNPs were mapped into previously described loci ( E2 , E4 , and Dt1 ) affecting maturity and plant height in soybean and a new locus mapped on chromosome 20 was significantly associated with plant height; Glyma.10g228900 , Glyma.19g200800 , Glyma.09g196700 , and Glyma.09g038300 were candidate genes found in the vicinity of the top or the second best SNP for maturity, plant height, seed weight, and yield, respectively; a 11.5-Mb region of chromosome 10 was associated with both seed weight and yield; and GS accuracy was trait-, year-, and population structure-dependent. Conclusions The SNP markers identified from this study for plant height, maturity, seed weight and yield can be used to improve the four agronomic traits through marker-assisted selection (MAS) and GS in soybean breeding programs. After validation, the candidate genes can be transferred to new cultivars using SNP markers through MAS. The high GS accuracy has confirmed that the four agronomic traits can be selected in molecular breeding through GS.

scholarly journals Genome-wide association study and genomic selection for tolerance of soybean biomass to soybean cyst nematode infestation

PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0235089
Author(s):  
Waltram Second Ravelombola ◽  
Jun Qin ◽  
Ainong Shi ◽  
Liana Nice ◽  
Yong Bao ◽  
...  
Keyword(s):  
Association Study ◽  
Genomic Selection ◽  
Soybean Cyst Nematode ◽  
Genome Wide Association Study ◽  
Cyst Nematode ◽  
Genome Wide Association ◽  
Genome Wide ◽  
Selection For

scholarly journals Defining the genetic control of human blood plasma N-glycome using genome-wide association study

2018 ◽  
Author(s):  
Sodbo Zh. Sharapov ◽  
Yakov A. Tsepilov ◽  
Lucija Klaric ◽  
Massimo Mangino ◽  
Gaurav Thareja ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Association Study ◽  
Genetic Control ◽  
Human Blood ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Human Blood Plasma ◽  
Genome Wide ◽  
A Genome

AbstractGlycosylation is a common post-translational modification of proteins. It is known, that glycans are directly involved in the pathophysiology of every major disease. Defining genetic factors altering glycosylation may provide a basis for novel approaches to diagnostic and pharmaceutical applications. Here, we report a genome-wide association study of the human blood plasma N-glycome composition in up to 3811 people. We discovered and replicated twelve loci. This allowed us to demonstrate a clear overlap in genetic control between total plasma and IgG glycosylation. Majority of loci contained genes that encode enzymes directly involved in glycosylation (FUT3/FUT6, FUT8, B3GAT1, ST6GAL1, B4GALT1, ST3GAL4, MGAT3, and MGAT5). We, however, also found loci that are likely to reflect other, more complex, aspects of plasma glycosylation process. Functional genomic annotation suggested the role of DERL3, which potentially highlights the role of glycoprotein degradation pathway, and such transcription factor as IKZF1.

scholarly journals Defining the genetic control of human blood plasma N-glycome using genome-wide association study

2019 ◽  
Author(s):  
Sodbo Zh Sharapov ◽  
Yakov A Tsepilov ◽  
Lucija Klaric ◽  
Massimo Mangino ◽  
Gaurav Thareja ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Association Study ◽  
Genetic Control ◽  
Human Blood ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Human Blood Plasma ◽  
Genome Wide

scholarly journals Genome-wide association study and genomic selection for yield and related traits in soybean

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255761
Author(s):  
Waltram Ravelombola ◽  
Jun Qin ◽  
Ainong Shi ◽  
Qijian Song ◽  
Jin Yuan ◽  
...  
Keyword(s):  
Association Study ◽  
Genomic Selection ◽  
Plant Height ◽  
Seed Weight ◽  
Genome Wide Association Study ◽  
Agronomic Traits ◽  
Snp Markers ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

Soybean [Glycine max (L.) Merr.] is a crop of great interest worldwide. Exploring molecular approaches to increase yield genetic gain has been one of the main challenges for soybean breeders and geneticists. Agronomic traits such as maturity, plant height, and seed weight have been found to contribute to yield. In this study, a total of 250 soybean accessions were genotyped with 10,259 high-quality SNPs postulated from genotyping by sequencing (GBS) and evaluated for grain yield, maturity, plant height, and seed weight over three years. A genome-wide association study (GWAS) was performed using a Bayesian Information and Linkage Disequilibrium Iteratively Nested Keyway (BLINK) model. Genomic selection (GS) was evaluated using a ridge regression best linear unbiased predictor (rrBLUP) model. The results revealed that 20, 31, 37, and 23 SNPs were significantly associated with maturity, plant height, seed weight, and yield, respectively; Many SNPs were mapped to previously described maturity and plant height loci (E2, E4, and Dt1) and a new plant height locus was mapped to chromosome 20. Candidate genes were found in the vicinity of the two SNPs with the highest significant levels associated with yield, maturity, plant height, seed weight, respectively. A 11.5-Mb region of chromosome 10 was associated with both yield and seed weight. Overall, the accuracy of GS was dependent on the trait, year, and population structure, and high accuracy indicates that these agronomic traits can be selected in molecular breeding through GS. The SNP markers identified in this study can be used to improve yield and agronomic traits through the marker-assisted selection and GS in breeding programs.

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