scholarly journals Potential Role of Sodium-Proton Exchangers in the Low Concentration Arsenic Trioxide-Increased Intracellular pH and Cell Proliferation

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e51451 ◽  
Author(s):  
Carmen Aravena ◽  
Ana R. Beltrán ◽  
Marcelo Cornejo ◽  
Viviana Torres ◽  
Emilce S. Díaz ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Arsenic Trioxide ◽  
Intracellular Ph ◽  
Potential Role ◽  
Low Concentration

scholarly journals Hepatic stellate cell proliferation: A potential role of protein kinase R

Hepatology ◽  
2011 ◽  
Vol 54 (4) ◽  
pp. 1484-1485 ◽  
Author(s):  
Sara Ceccarelli ◽  
Nadia Panera ◽  
Anna Alisi ◽  
Valerio Nobili
Keyword(s):  
Cell Proliferation ◽  
Protein Kinase ◽  
Hepatic Stellate Cell ◽  
Potential Role ◽  
Stellate Cell ◽  
Protein Kinase R

Role of Intracellular pH in Mammalian Cell Proliferation

1992 ◽  
Vol 2 (3-4) ◽  
pp. 159-179 ◽  
Author(s):  
R.J. Gillies ◽  
R. Martinez-Zaguilan ◽  
E.P. Peterson ◽  
R. Perona
Keyword(s):  
Cell Proliferation ◽  
Intracellular Ph ◽  
Mammalian Cell

Molecular Pathogenesis of Sporadic Melanoma and Melanoma-Initiating Cells

2010 ◽  
Vol 134 (12) ◽  
pp. 1740-1749
Author(s):  
Yunyi Kong ◽  
Suresh M. Kumar ◽  
Xiaowei Xu
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Biology ◽  
Molecular Basis ◽  
Potential Role ◽  
Genetic Alterations ◽  
Stem Cell Biology ◽  
Prevalent Disease

Abstract Recent advances in molecular genetics and cancer stem cell biology have shed some light on the molecular basis of melanomagenesis. In this review, we will focus on major genetic alterations in the melanoma, particularly pathways involved in cell proliferation, apoptosis, and tumor suppression. The potential role of melanoma-initiating cells during melanomagenesis and progression will also be discussed. Understanding pathogenesis of melanoma may uncover new diagnostic clues and therapeutic targets for this increasingly prevalent disease.

Aberrant microRNA Expression in Radiation-Induced Rat Mammary Cancer: The Potential Role of miR-194 Overexpression in Cancer Cell Proliferation

2012 ◽  
Vol 179 (2) ◽  
pp. 151 ◽  
Author(s):  
Daisuke Iizuka ◽  
Tatsuhiko Imaoka ◽  
Mayumi Nishimura ◽  
Hidehiko Kawai ◽  
Fumio Suzuki ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Mammary Cancer ◽  
Potential Role ◽  
Microrna Expression ◽  
Cancer Cell Proliferation ◽  
Radiation Induced

Potential role of NF-kB in the negative regulation of human hepatic stellate cell proliferation

1998 ◽  
Vol 28 ◽  
pp. 83
Author(s):  
C. Gallois ◽  
A. Habib ◽  
T. Jiangchuang ◽  
J. Maclouf ◽  
A. Mallat ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Hepatic Stellate Cell ◽  
Potential Role ◽  
Stellate Cell ◽  
Negative Regulation ◽  
Human Hepatic Stellate Cell

scholarly journals Effect of lncRNA PVT1/miR186/KLF5 Axis on the Occurrence and Progression of Cholangiocarcinoma

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Qiang Sun ◽  
Xueyi Gong ◽  
Jianlong Wu ◽  
Zhipeng Hu ◽  
Qiao Zhang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Lines ◽  
Cell Invasion ◽  
Noncoding Rna ◽  
Potential Role ◽  
Bioinformatic Analysis ◽  
Tumor Formation ◽  
Invasion Assay ◽  
Transwell Invasion Assay

This study primarily focused on the effect of the long noncoding RNA (lncRNA) PVT1/miR186/KLF5 axis on the occurrence and progression of cholangiocarcinoma (CCA). miR186 was found both in the lncRNA PVT1 targeting miRNAs and KLF5 targeting miRNAs using bioinformatic analysis. The expression of lncRNA PVT1 and KLF5 in the TFK-1, QBC939, and HuCCT1 cell lines and normal biliary epithelial HIBEpiC cells was detected by RT-qPCR. The significance of lncRNA PVT1 and KLF5 on cell proliferation was analyzed using the MTT assay and clone formation assay in lncRNA PVT1 and KLF5 silencing HuCCT1 cell lines and lncRNA PVT1and KLF5 overexpressing TFK-1 and QBC939 cell lines, respectively. The potential role of lncRNA PVT1 and KLF5 in cell migration was detected using the transwell invasion assay in CCA cell lines and tumor formation assay. Additionally, lncRNA PVT1 and KLF5 were proved to be highly expressed in CCA tissues and cell lines. Silencing and overexpressing of lncRNA PVT1 or KLF5 markedly inhibited or increased the cell proliferation and cell invasion in CCA cell lines, respectively. Silencing and overexpressing of lncRNA PVT1 significantly inhibited and increased the expression of KLF5 in CCA cell lines, respectively. Silencing of lncRNA PVT1 increased the expression of miR186, and silencing of miR186 increased the expression of KLF5 in CCA cell lines. Cotransfection of lncRNA PVT1 and miR186 increased the expression of KLF5 compared with controls. Overall, these results demonstrated that the lncRNA PVT1/miR186/KLF5 axis might exert a key role in the occurrence and progression of CCA, and this axis might provide a new target for treating CCA.

Sign in / Sign up

Export Citation Format

Share Document