scholarly journals De Novo Characterization of Japanese Scallop Mizuhopecten yessoensis Transcriptome and Analysis of Its Gene Expression following Cadmium Exposure

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e64485 ◽  
Author(s):  
Xiao-lin Meng ◽  
Mei Liu ◽  
Ke-yong Jiang ◽  
Bao-jie Wang ◽  
Xue Tian ◽  
...  
Keyword(s):  
Gene Expression ◽  
De Novo ◽  
Cadmium Exposure ◽  
Japanese Scallop ◽  
Mizuhopecten Yessoensis ◽  
Its Gene

scholarly journals De novo characterization of a whitefly transcriptome and analysis of its gene expression during development

BMC Genomics ◽  
2010 ◽  
Vol 11 (1) ◽  
pp. 400 ◽  
Author(s):  
Xiao-Wei Wang ◽  
Jun-Bo Luan ◽  
Jun-Min Li ◽  
Yan-Yuan Bao ◽  
Chuan-Xi Zhang ◽  
...  
Keyword(s):  
Gene Expression ◽  
De Novo ◽  
Its Gene

Gene Expression Profile of Acute Myeloid Leukemia (AML) with t(8;16)(p11;p13) and MYST3/CREBBP Rearrangement.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 2054-2054
Author(s):  
Mireia Camos ◽  
Jordi Esteve ◽  
Pedro Jares ◽  
Maria Rozman ◽  
Dolors Colomer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
De Novo ◽  
Normal Karyotype ◽  
Genetic Profile ◽  
Transferase Activity ◽  
Internal Tandem Duplication ◽  
Its Gene ◽  
Differential Expression Profile

Abstract Translocation t(8;16)(p11;p13) is an infrequent chromosomal abnormality in de novo and secondary AML cases, leading to the fusion of MYST3 (MOZ) and CREBBP (CBP) genes, both of them harboring histone lysine acetyl-transferase activity. This AML variety displays specific clinical and biological features, although its gene expression profile is currently unknown. In this study, the genetic signature of AML cases with MYST3/CREBBP rearrangement was compared with the genetic profile of other well-defined AML subtypes. Genotypic analyses using oligonucleotide U133A arrays (Affymetrix) were performed on RNA of 19 AML samples, including t(8;16)-AML (n=3), t(15;17) (n=3), t(8;21) (n=2), inv(16)/t(16;16) (n=3), t(9;11) with AF9/MLL rearrangement (n=2), 3 cases with normal karyotype and flt-3 internal tandem duplication (flt-3 ITD), the three remaining samples corresponding to monocytic cases (M4/M5) without MLL rearrangement nor flt-3 ITD. After unsupervised analysis, cases of AML with t(8;16) clustered together, displaying a differential expression profile. Supervised analysis allowed the identification of the top 53 up-regulated and 28 down-regulated genes. Among the set of genes overexpressed, genes involved in chromatin remodelling and transcription (HOXA9, HOXA10, MEIS1, CHD3, SATB1) and protooncogenes (RET, flt-3, LMO2) were identified. In contrast, CREBBP gene and several members of the JAK-STAT pathway (STAT3, STAT5B, JAK2) were underexpressed. Interestingly, overexpression of multiple homeobox genes was detected in flt-3 ITD cases, some of them as a distinctive finding (HOXA2, HOXA3, HOXB6), and others (HOXA9, HOXA10, MEIS1) were found to be highly expressed in MYST3/CREBBP and MLL-rearranged samples. In conclusion, AML with t(8;16) and MYST3/CREBBP rearrangement shows a distinctive gene expression profile, with some similarities with MLL rearranged leukemias and flt-3 ITD AML cases, thus suggesting a partially common leukemogenic pathway.

De novo characterization of the antler tip of Chinese Sika deer transcriptome and analysis of gene expression related to rapid growth

2011 ◽  
Vol 364 (1-2) ◽  
pp. 93-100 ◽  
Author(s):  
Baojin Yao ◽  
Yu Zhao ◽  
Qun Wang ◽  
Mei Zhang ◽  
Meichen Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rapid Growth ◽  
Sika Deer ◽  
De Novo ◽  
Chinese Sika Deer ◽  
Antler Tip

scholarly journals Molecular Characterization of a Senescence-Associated Gene Encoding Cysteine Proteinase and its Gene Expression during Leaf Senescence in Sweet Potato

2002 ◽  
Vol 43 (9) ◽  
pp. 984-991 ◽  
Author(s):  
Guan-Hong Chen ◽  
Lin-Tzu Huang ◽  
Mee-Ngan Yap ◽  
Ruey-Hua Lee ◽  
Yih-Jong Huang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Molecular Characterization ◽  
Sweet Potato ◽  
Leaf Senescence ◽  
Cysteine Proteinase ◽  
Gene Encoding ◽  
Its Gene

scholarly journals Transcriptional signatures of somatic neoblasts and germline cells in Macrostomum lignano

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Magda Grudniewska ◽  
Stijn Mouton ◽  
Daniil Simanov ◽  
Frank Beltman ◽  
Margriet Grelling ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
De Novo ◽  
Transcriptome Assembly ◽  
Model Organism ◽  
Proliferating Cells ◽  
Macrostomum Lignano ◽  
Germline Cells

The regeneration-capable flatworm Macrostomum lignano is a powerful model organism to study the biology of stem cells in vivo. As a flatworm amenable to transgenesis, it complements the historically used planarian flatworm models, such as Schmidtea mediterranea. However, information on the transcriptome and markers of stem cells in M. lignano is limited. We generated a de novo transcriptome assembly and performed the first comprehensive characterization of gene expression in the proliferating cells of M. lignano, represented by somatic stem cells, called neoblasts, and germline cells. Knockdown of a selected set of neoblast genes, including Mlig-ddx39, Mlig-rrm1, Mlig-rpa3, Mlig-cdk1, and Mlig-h2a, confirmed their crucial role for the functionality of somatic neoblasts during homeostasis and regeneration. The generated M. lignano transcriptome assembly and gene expression signatures of somatic neoblasts and germline cells will be a valuable resource for future molecular studies in M. lignano.

scholarly journals De Novo Foliar Transcriptome of Chenopodium amaranticolor and Analysis of Its Gene Expression During Virus-Induced Hypersensitive Response

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e45953 ◽  
Author(s):  
Yongqiang Zhang ◽  
Xinwu Pei ◽  
Chao Zhang ◽  
Zifeng Lu ◽  
Zhixing Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hypersensitive Response ◽  
De Novo ◽  
Chenopodium Amaranticolor ◽  
Its Gene
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