scholarly journals From a Traditional Medicinal Plant to a Rational Drug: Understanding the Clinically Proven Wound Healing Efficacy of Birch Bark Extract

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e86147 ◽  
Author(s):  
Sandra Ebeling ◽  
Katrin Naumann ◽  
Simone Pollok ◽  
Tina Wardecki ◽  
Sabine Vidal-y-Sy ◽  
...  
Keyword(s):  
Wound Healing ◽  
Medicinal Plant ◽  
Bark Extract ◽  
Birch Bark ◽  
Rational Drug

scholarly journals Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4799
Author(s):  
Francis Kamau Mwiiri ◽  
Rolf Daniels
Keyword(s):  
Molecular Weight ◽  
Wound Healing ◽  
Drug Release ◽  
Polymer Solutions ◽  
Ex Vivo ◽  
Polymer Concentration ◽  
Weight Ratio ◽  
Bark Extract ◽  
Birch Bark ◽  
Fiber Morphology

Triterpenes from the outer bark of birch (TE) are known for various pharmacological effects including enhanced wound healing. Apart from an already authorized oleogel, electrospun nanofiber mats containing these triterpenes in a polyvinyl alcohol (PVA) matrix appear to be an advantageous application form. The effects of PVA molecular weight and concentration on the fiber morphology have been investigated. Three different molecular weights of PVA ranging from 67 to 186 kDa were used. The concentration of PVA was varied from 5 to 20 wt%. Polymer solutions were blended with colloidal dispersions of birch bark extract at a weight ratio of 60:40 (wt.%). The estimated viscosity of polymer solutions was directly linked to their concentration and molecular weight. In addition, both pure and blended solutions showed viscoelastic properties with a dominant viscous response in the bulk. Fiber morphology was confirmed using scanning electron microscopy (SEM). Both polymer concentration and molecular weight were found to be significant factors affecting the diameter of the fibers. Fiber diameter increased with a higher molecular weight and polymer concentration as more uniform fibers were obtained using PVA of higher molecular weight (146–186 kDa). In vitro drug release and ex vivo permeation studies indicated a faster drug release of betulin from electrospun scaffolds with lower PVA molecular weight. Our research suggests that the fabricated TE-loaded PVA electrospun dressings represent potential delivery systems of TE for wound care applications.

Triterpenes from birch bark extract beneficially affect wound healing

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
K Naumann ◽  
S Ebeling ◽  
M Laszczyk ◽  
A Scheffler ◽  
I Merfort
Keyword(s):  
Wound Healing ◽  
Bark Extract ◽  
Birch Bark

Complexation with Hydroxypropyl-gama-Cyclodextrin of Birch Tree Extract Physico-chemical Characterisation of their Binary Products

2008 ◽  
Vol 59 (6) ◽  
Author(s):  
Codruta Soica ◽  
Cristina A. Dehelean ◽  
Valentin Ordodi ◽  
Diana Antal ◽  
Vicentiu Vlaia
Keyword(s):  
Inclusion Complexes ◽  
Water Solubility ◽  
In Vitro Dissolution ◽  
Molar Ratio ◽  
Bark Extract ◽  
Birch Bark ◽  
Preparation Methods ◽  
Birch Tree ◽  
Physico Chemical

Birch bark contains important pentacyclic triterpens that determine an anticancer, anti-inflammatory and antiviral activity. The compounds can be extracted by simple procedures with organic solvents. The major problem of this type of triterpens is their low water solubility which can be increased by physical procedures like cyclodextrin complexation. The aim of present study was to analyse the products between birch bark extract and hydroxypropyl-g -cyclodextrin. Hydroxypropyl-g -cyclodextrin (HPGCD) was used as a host to improve its solubility in water, via inclusion complex formation. In order to obtain the inclusion complexes, 1:2 molar ratio and two preparation methods (physical mixing, kneading) were used. The inclusion complexes were analyzed by in vitro dissolution tests, thermal analysis and X-ray diffraction.

scholarly journals Evaluation of the quality and safety of butter with an antioxidant complex of natural origin (birch bark extract and Aloe Vera)

2021 ◽  
Vol 640 (3) ◽  
pp. 032004
Author(s):  
A P Simonenkova ◽  
A V Mamaev ◽  
V N Masalov ◽  
O N Luneva ◽  
E N Demina ◽  
...  
Keyword(s):  
Aloe Vera ◽  
Bark Extract ◽  
Birch Bark ◽  
Quality And Safety ◽  
Natural Origin

Macro-microscopic Atlas on Heartwood of Pterocarpus santalinus L.f. (Red sandalwood)

2021 ◽  
pp. 3927-3930
Author(s):  
Susikumar S ◽  
Nartunai G ◽  
Ilavarasan R
Keyword(s):  
Wound Healing ◽  
Medicinal Plant ◽  
Calcium Oxalate ◽  
Tamil Nadu ◽  
Andhra Pradesh ◽  
South India ◽  
Deciduous Tree ◽  
Starch Grains ◽  
Herbal Formulation ◽  
Pterocarpus Santalinus

Background: Pterocarpus santalinus L.f. (Fam. Leguminosae) is a medium sized, deciduous tree distributed in South India mainly in Andhra Pradesh, Karnataka and Tamil Nadu. The heartwood is highly prized and medicinally useful. The heartwood is used in Indian system of medicine for leucorrhoea, piles, syphilis, vomiting, fever, thirst, purifying blood and in wound healing. Pterocarpus santalinus is one of the ingredients in many Siddha and Ayurvedic formulations namely Cintil Ney, Senchandana Manapagu, Candana Bala, Laksadi Taila and Candanadi lauha. Objective: The present study brings out macro-microscopic atlas on heartwood of medicinal plant Pterocarpus santalinus L.f. Materials and Methods: Sections and powder were observed and photographed under different magnifications with the help of Olympus BX51 Microscopic unit fitted with Olympus Camera. Results: Macroscopically colour, odour and taste; microscopically tyloses, needle eye end fibres, forked fibres with pegged and sharp end, pitted and border pitted vessels, uni-seriate medullary rays, Reddish brownish content, oil globules, simple starch grains, crystal fibres and prismatic crystals of calcium oxalate are the unique diagnostic characters reported. Conclusion: The finding of the present study is believed to be helpful in identifying the genuineness of the heartwood in crude raw drug and also in standardization of herbal formulation containing red sandalwood as ingredient.

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