scholarly journals Association between CD14 Gene Polymorphisms and Cancer Risk: A Meta-Analysis

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e100122 ◽  
Author(s):  
Jun Wang ◽  
Xufeng Guo ◽  
Shijie Yu ◽  
Jia Song ◽  
Jixiang Zhang ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Cd14 Gene

scholarly journals Association between CASP-8 gene polymorphisms and cancer risk in some Asian population based on a HuGE review and meta-analysis

2013 ◽  
Vol 12 (4) ◽  
pp. 6466-6476 ◽  
Author(s):  
Y.J. Zhang ◽  
X.P. Zhong ◽  
Y. Chen ◽  
S.R. Liu ◽  
G. Wu ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Asian Population ◽  
Population Based

Meta-analysis of association between cytokine gene polymorphisms and lung cancer risk

2011 ◽  
Vol 39 (5) ◽  
pp. 5187-5194 ◽  
Author(s):  
Wen-jia Peng ◽  
Qian He ◽  
Jin-xia Yang ◽  
Bing-xiang Wang ◽  
Man-man Lu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Cytokine Gene ◽  
Cytokine Gene Polymorphisms

scholarly journals Association between HLA-DP Gene Polymorphisms and Cervical Cancer Risk: A Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Lin Cheng ◽  
Yan Guo ◽  
Shipeng Zhan ◽  
Peiyuan Xia
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Human Leukocyte ◽  
Cervical Cancer Risk ◽  
Leukocyte Antigens ◽  
Knowledge Infrastructure ◽  
Increased Risk ◽  
The Relationship

Objective. We aimed to derive a more precise estimation of the associations between human leukocyte antigens DP (HLA-DP) gene polymorphisms and cervical cancer risk by meta-analysis. Methods. PubMed, EMBASE, ScienceDirect, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases were systematically searched to identify studies investigating the relationship between HLA-DP gene polymorphisms and cervical cancer. The associations between them were evaluated by pooled OR and 95% CI. Results. A total of 11 studies including 5008 cases and 9322 controls with 11 HLA-DP alleles were included in the current meta-analysis. Results. The results showed that HLA-DPB1⁎03:01 was significantly associated with an increased risk of cervical cancer (OR=1.252, 95%CI: 1.116-1.403, Pz=0.001), while HLA-DPB1⁎04:02 and HLA-DP rs3117027 G allele were significantly associated with a decreased risk of cervical cancer (OR=0.744, 95%CI: 0.652-0.848, Pz=0.001; OR=0.790, 95%CI: 0.745-0.837, Pz=0.001), and HLA-DP rs9277535 G allele was significantly associated with a decreased risk of cervical cancer in Asia (OR=0.802, 95%CI: 0.753-0.855, Pz=0.001). Subgroup analyses based on race system showed that HLA-DPB1⁎13:01 was significantly associated with an increased risk of cervical cancer in Asia (OR=1.834, 95%CI: 1.107-3.039, Pz=0.019). No significant association was established for the HLA-DP following alleles: DPB1⁎02:01, DPB1⁎02:02, DPB1⁎04:01, DPB1⁎05:01, rs4282438, and rs3077. Conclusion. HLA-DP gene polymorphisms (HLA-DPB1⁎03:01, DPB1⁎04:02, DPB1⁎13:01, rs9277535, and rs3117027) were significantly associated with cervical cancer.

scholarly journals Associations of common IL-4 gene polymorphisms with cancer risk: A meta-analysis

2017 ◽  
Vol 16 (2) ◽  
pp. 1927-1945 ◽  
Author(s):  
Yingxian Jia ◽  
Xiaochuan Xie ◽  
Xiaohan Shi ◽  
Shangwei Li
Keyword(s):  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Meta Analysis

scholarly journals The effect of LTA gene polymorphisms on cancer risk: an updated systematic review and meta- analysis

2020 ◽  
Vol 40 (5) ◽  
Author(s):  
Jingdong Li ◽  
Yaxuan Wang ◽  
Xueliang Chang ◽  
Zhenwei Han
Keyword(s):  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Cancer Type ◽  
Non Hodgkin Lymphoma ◽  
Increased Risk ◽  
Lymphotoxin Alpha ◽  
Stratified Analysis ◽  
Lymphotoxin Α ◽  
Risk Of Cancer

Abstract Purpose: To provide a comprehensive account of the association of five Lymphotoxin-α (LTA) gene polymorphisms (rs1041981, rs2229094, rs2239704, rs746868, rs909253) with susceptibility to cancer. Methods: A literature search for eligible candidate gene studies published before 28 February 2020 was conducted in the PubMed, Medline, Google Scholar and Web of Science. The following combinations of main keywords were used: (LTA OR Lymphotoxin alpha OR TNF-β OR tumor necrosis factor-beta) AND (polymorphism OR mutation OR variation OR SNP OR genotype) AND (cancer OR tumor OR neoplasm OR malignancy OR carcinoma OR adenocarcinoma). Potential sources of heterogeneity were sought out via subgroup and sensitivity analysis, and publication bias were estimated. Results: Overall, a total of 24 articles with 24577 cases and 33351 controls for five polymorphisms of LTA gene were enrolled. We identified that rs2239704 was associated with a reduced risk of cancer. While for other polymorphisms, the results showed no significant association with cancer risk. In the stratified analysis of rs1041981, we found that Asians might have less susceptibility to cancer. At the same time, we found that rs2239704 was negatively correlated with non-Hodgkin lymphoma (NHL). While, for rs909253, an increased risk of cancer for Caucasians and HCC susceptibility were uncovered in the stratified analysis of by ethnicity and cancer type. Conclusion: LTA rs2239704 polymorphism is inversely associated with the risk of cancer. LTA rs1041981 polymorphism is negatively associated with cancer risk in Asia. While, LTA rs909253 polymorphism is a risk factor for HCC in Caucasian population.

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