scholarly journals Correction: Suppression of MAPK Signaling and Reversal of mTOR-Dependent MDR1-Associated Multidrug Resistance by 21α-Methylmelianodiol in Lung Cancer Cells

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0133922 ◽  
Author(s):  
Mark Borris Docdoc Aldonza ◽  
Ji-Young Hong ◽  
Song Yi Bae ◽  
Jayoung Song ◽  
Won Kyung Kim ◽  
...  
PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0127841 ◽  
Author(s):  
Mark Borris Docdoc Aldonza ◽  
Ji-Young Hong ◽  
Song Yi Bae ◽  
Jayoung Song ◽  
Won Kyung Kim ◽  
...  

2021 ◽  
Vol 11 (5) ◽  
pp. 963-969
Author(s):  
Wenhong Zheng ◽  
Wenrui Xie ◽  
Lijuan Fu ◽  
Zhengqi Fu

The lung cancer was most deadly tumor in the world and the suvival rate needs to be improved clinically and urgently. The abnormal miR-340 expression is found in several solid tumors. Our study was aimed to explore miR-340’s role in lung cancer. 14 cases of patients with lung cancer was selected to measure miR-340 level by RT-PCR and analyze its correlation with clinical characteristics. The relation between the miR-340 and DICER1 was detected by dual luciferase assay and cell proliferation was measured by MTT assay along with analysis of cell migration and invasive by Scratch-Wound experiment. The miR-340 in lung cancer cells was reduced significantly and DICER1 was predicted to be a potential target of miR-340. DICER1 level was found to be negatively related with miR-340 level. The DICER1 as the direct target gene of miR-340 was conducive to improve miR-340 function through overexpression and knock-out experiment further. Abnormal miR-340 level affected lung cancer cell proliferation and migration as well as MAPK signaling. miR-340 could affect the biological morphology and transformation of physiological function of lung cancer cells mainly through restraining the expression of apoptosis and prompting the cellular proliferation, indicating that it might be a novel target to improve the treatment of lung cancer.


2020 ◽  
Vol 10 ◽  
Author(s):  
Zhuo-Xun Wu ◽  
Zheng Peng ◽  
Yuqi Yang ◽  
Jing-Quan Wang ◽  
Qiu-Xu Teng ◽  
...  

2020 ◽  
Vol 149 ◽  
pp. 218-228 ◽  
Author(s):  
Sasivimon Pramual ◽  
Kriengsak Lirdprapamongkol ◽  
Valérie Jouan-Hureaux ◽  
Muriel Barberi-Heyob ◽  
Céline Frochot ◽  
...  

1999 ◽  
Vol 258 (3) ◽  
pp. 513-518 ◽  
Author(s):  
Léa Payen ◽  
Laurence Delugin ◽  
Arnaud Courtois ◽  
Yolande Trinquart ◽  
André Guillouzo ◽  
...  

2014 ◽  
Vol 11 (1) ◽  
pp. 682-690 ◽  
Author(s):  
ZUOLIANG DONG ◽  
LI REN ◽  
LI LIN ◽  
JIANG LI ◽  
YIWEN HUANG ◽  
...  

1996 ◽  
Vol 74 (12) ◽  
pp. 1929-1934 ◽  
Author(s):  
Y Abe ◽  
Y Ohnishi ◽  
M Yoshimura ◽  
E Ota ◽  
Y Ozeki ◽  
...  

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Shohei Kanno ◽  
Keita Utsunomiya ◽  
Yumiko Kono ◽  
Noboru Tanigawa ◽  
Satoshi Sawada

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