Inactivated Eyedrop Influenza Vaccine Adjuvanted with Poly(I:C) Is Safe and Effective for Inducing Protective Systemic and Mucosal Immunity

Hay fever is an increasing disease in Japan, and the prevalence of cedar pollinosis exceeds 20% nationwide. More than 50 kinds of pollen have been reported so far in Japan. Pollinosis often complicated other allergic conditions. Since patients with allergic diseases have lower s-IgA levels than healthy subjects, patients with hay fever have less weak mucosal immunity so that it would affect the efficacy of the influenza vaccine. Eight thousand three hundred thirty-seven (3885 men and 4452 women) participated in this survey to clarify the relationship between allergic diseases and the influenza vaccine's efficacy. In the no hay fever group, the effective vaccine rate against influenza disease was 0.2%, and in the hay fever group, it was 0.21%. No effect of the influenza vaccine was present in this population. Rather, vaccination seemed to increase influenza incidence in people with hay fever. The basic presence of allergic condition influenza vaccination increased susceptibility to influenza infection. (12.9% vs. 13.89%) (p<0.001). A tailor-made strategy for these patients should be necessary for preventing influenza.

Download Full-text

Salmonella flagellin enhances mucosal immunity of avian influenza vaccine in chickens

Veterinary Microbiology ◽

10.1016/j.vetmic.2011.12.014 ◽

2012 ◽

Vol 157 (1-2) ◽

pp. 69-77 ◽

Cited By ~ 26

Author(s):

Hso-Chi Chaung ◽

Li-Ting Cheng ◽

Li-Hsiang Hung ◽

Pei-Chun Tsai ◽

Ioanna Skountzou ◽

...

Keyword(s):

Avian Influenza ◽

Influenza Vaccine ◽

Mucosal Immunity

Download Full-text

Induction of lung CD8 + T cell responses by consecutive inoculations of a poly(I:C) influenza vaccine

Vaccine ◽

10.1016/j.vaccine.2017.10.038 ◽

2017 ◽

Vol 35 (48) ◽

pp. 6620-6626 ◽

Cited By ~ 3

Author(s):

Miyu Moriyama ◽

Haruko Takeyama ◽

Hideki Hasegawa ◽

Takeshi Ichinohe

Keyword(s):

T Cell ◽

Influenza Vaccine ◽

T Cell Responses ◽

Cd8 T Cell ◽

Poly I:C ◽

Cell Responses

Download Full-text

Poly I:C adjuvanted inactivated swine influenza vaccine induces heterologous protective immunity in pigs

Vaccine ◽

10.1016/j.vaccine.2014.11.034 ◽

2015 ◽

Vol 33 (4) ◽

pp. 542-548 ◽

Cited By ~ 20

Author(s):

Milton Thomas ◽

Zhao Wang ◽

Chithra C. Sreenivasan ◽

Ben M. Hause ◽

Gourapura J. Renukaradhya ◽

...

Keyword(s):

Influenza Vaccine ◽

Protective Immunity ◽

Swine Influenza ◽

Poly I:C

Download Full-text

Immunological efficacy of self-assembled nanoparticle anti-mite vaccine

10.1101/620823 ◽

2019 ◽

Author(s):

Sean Kowalski ◽

John Smith

Keyword(s):

Immune Response ◽

Nasal Mucosa ◽

Specific Antibody ◽

Mucosal Immunity ◽

Poly I:C ◽

Mouse Serum ◽

Enzyme Linked Immunosorbent Assay ◽

Strong Immune Response ◽

Self Assembled ◽

Antibody Levels

AbstractThis report demonstrates the effects of self-assembled nanoparticle anti-caries vaccine Glu-FTH and Glu+ Poly(I:C) (in combination with adjuvant Poly(I:C) and antigen Glu) on specific humoral and mucosal immunity in mice. Mice were randomly divided into 6 groups, and Glu-FTH, Glu, Glu-FTH + Poly (I: C), Glu+Poly (I: C), FTH, and PBS were injected into mice via nasal mucosa. Enzyme-linked immunosorbent assay (ELISA) to detect specific antibody levels in serum and saliva. Results indicate that Glu-FTH, Glu, Glu-FTH+Poly(I:C), Glu+Poly(I:C) can effectively increase anti-Glu IgG levels in mouse serum; Glu+Poly(I:C) and Glu It can effectively increase the level of anti-GlusIgA in mouse saliva. Therefore, we demonstrate that Glu-FTH has a certain immune effect. The combination of adjuvant Poly(I:C) and antigen Glu can induce strong immune response.

Download Full-text