scholarly journals Spatial Distribution of Sand Fly Vectors and Eco-Epidemiology of Cutaneous Leishmaniasis Transmission in Colombia

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0139391 ◽  
Author(s):  
Cristina Ferro ◽  
Marla López ◽  
Patricia Fuya ◽  
Ligia Lugo ◽  
Juan Manuel Cordovez ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Cutaneous Leishmaniasis ◽  
Sand Fly ◽  
Sand Fly Vectors

scholarly journals Cutaneous Leishmaniasis in dogs: is high seroprevalence indicative of a reservoir role?

Parasitology ◽  
2015 ◽  
Vol 142 (9) ◽  
pp. 1202-1214 ◽  
Author(s):  
JOSÉ E. CALZADA ◽  
AZAEL SALDAÑA ◽  
KADIR GONZÁLEZ ◽  
CHYSTRIE RIGG ◽  
VANESSA PINEDA ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Complex Disease ◽  
Basic Reproductive Number ◽  
Sand Fly ◽  
Reproductive Number ◽  
Cross Sectional ◽  
Rich Diversity ◽  
Ecosystem Level ◽  
Reservoir Hosts ◽  
Sand Fly Vectors

SUMMARYAmerican cutaneous leishmaniasis (ACL) is a complex disease with a rich diversity of animal host species. This diversity imposes a challenge, since understanding ACL transmission requires the adequate identification of reservoir hosts, those species able to be a source of additional infections. In this study we present results from an ACL cross-sectional serological survey of 51 dogs (Canis familiaris), where we used diagnostic tests that measure dog's exposure toLeishmaniaspp. parasites. We did our research in Panamá, at a village that has undergone significant ecosystem level transformations. We found an ACL seroprevalence of 47% among dogs, and their exposure was positively associated with dog age and abundance of sand fly vectors in the houses of dog owners. Using mathematical models, which were fitted to data on the proportion of positive tests as function of dog age, we estimated a basic reproductive number (R0±s.e.) of 1·22 ± 0·09 that indicates the disease is endemically established in the dogs. Nevertheless, this information by itself is insufficient to incriminate dogs as ACL reservoirs, given the inability to find parasites (or their DNA) in seropositive dogs and previously reported failures to experimentally infect vectors feeding on dogs with ACL parasites.

Sand Fly Vectors of American Cutaneous Leishmaniasis in Brazil

2018 ◽  
pp. 341-380 ◽  
Author(s):  
Elizabeth F. Rangel ◽  
Ralph Lainson ◽  
Bruno M. Carvalho ◽  
Simone M. Costa ◽  
Jeffrey J. Shaw
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Sand Fly ◽  
American Cutaneous Leishmaniasis ◽  
Sand Fly Vectors

Insecticide Barrier Spraying for the Control of Sand Fly Vectors of Cutaneous Leishmaniasis in Rural Guatemala

1995 ◽  
Vol 52 (6) ◽  
pp. 485-488 ◽  
Author(s):  
Michael J. Perich ◽  
Edgar D. Rowton ◽  
Nidia Rizzo ◽  
Alfred L. Hoch
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Sand Fly ◽  
Sand Fly Vectors

Molecular Mass Screening to Incriminate Sand Fly Vectors of Andean-type Cutaneous Leishmaniasis in Ecuador and Peru

2008 ◽  
Vol 79 (5) ◽  
pp. 719-721 ◽  
Author(s):  
Hirotomo Kato ◽  
Eduardo A. Gomez ◽  
Hiroyuki Iwata ◽  
Jorge D. Marco ◽  
Yoshihisa Hashiguchi ◽  
...  
Keyword(s):  
Molecular Mass ◽  
Cutaneous Leishmaniasis ◽  
Mass Screening ◽  
Sand Fly ◽  
Andean Type ◽  
Sand Fly Vectors

Leishmania spp. and leishmaniasis on the Caribbean islands

2019 ◽  
Author(s):  
Chaoqun Yao
Keyword(s):  
Puerto Rico ◽  
Dominican Republic ◽  
Trinidad And Tobago ◽  
Parasite Species ◽  
Sand Fly ◽  
Caribbean Islands ◽  
Leishmania Spp ◽  
The Caribbean ◽  
Human Infections ◽  
Sand Fly Vectors

Abstract The kinetoplastid protozoan Leishmania spp. cause leishmaniasis, which clinically exhibit mainly as a cutaneous, mucocutanous or visceral form depending upon the parasite species in humans. The disease is widespread geographically, leading to 20 000 annual deaths. Here, leishmaniases in both humans and animals, reservoirs and sand fly vectors on the Caribbean islands are reviewed. Autochthonous human infections by Leishmania spp. were found in the Dominican Republic, Guadeloupe and Martinique as well as Trinidad and Tobago; canine infections were found in St. Kitts and Grenada; and equine infections were found in Puerto Rico. Imported human cases have been reported in Cuba. The parasites included Leishmania amazonensis, Le. martiniquensis and Le. waltoni. Possible sand fly vectors included Lutzomyia christophei, Lu. atroclavatus, Lu. cayennensis and Lu. flaviscutellata as well as Phlebotomus guadeloupensis. Reservoirs included rats, rice rats and mouse opossum. An updated study is warranted for the control and elimination of leishmaniasis in the region because some of the data are four decades old.

scholarly journals A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in nonhuman primates

2015 ◽  
Vol 7 (290) ◽  
pp. 290ra90-290ra90 ◽  
Author(s):  
Fabiano Oliveira ◽  
Edgar Rowton ◽  
Hamide Aslan ◽  
Regis Gomes ◽  
Philip A. Castrovinci ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Nonhuman Primates ◽  
Mononuclear Cells ◽  
Rhesus Macaques ◽  
Parasite Burden ◽  
Salivary Protein ◽  
Sand Fly ◽  
Protein Vaccine ◽  
Peripheral Blood Mononuclear ◽  
Phlebotomus Duboscqi

Currently, there are no commercially available human vaccines against leishmaniasis. In rodents, cellular immunity to salivary proteins of sand fly vectors is associated to protection against leishmaniasis, making them worthy targets for further exploration as vaccines. We demonstrate that nonhuman primates (NHP) exposed to Phlebotomus duboscqi uninfected sand fly bites or immunized with salivary protein PdSP15 are protected against cutaneous leishmaniasis initiated by infected bites. Uninfected sand fly–exposed and 7 of 10 PdSP15-immunized rhesus macaques displayed a significant reduction in disease and parasite burden compared to controls. Protection correlated to the early appearance of Leishmania-specific CD4+IFN-γ+ lymphocytes, suggesting that immunity to saliva or PdSP15 augments the host immune response to the parasites while maintaining minimal pathology. Notably, the 30% unprotected PdSP15-immunized NHP developed neither immunity to PdSP15 nor an accelerated Leishmania-specific immunity. Sera and peripheral blood mononuclear cells from individuals naturally exposed to P. duboscqi bites recognized PdSP15, demonstrating its immunogenicity in humans. PdSP15 sequence and structure show no homology to mammalian proteins, further demonstrating its potential as a component of a vaccine for human leishmaniasis.

scholarly journals DISTINCT CELLULAR MIGRATION INDUCED BY Leishmania infantum chagasi AND SALIVA FROM Lutzomyia longipalpis IN A HEMORRHAGIC POOL MODEL

2014 ◽  
Vol 56 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Camila Oliveira Vasconcelos ◽  
Zirlane C. Branco Coelho ◽  
Cristina de Souza Chaves ◽  
Clarissa Romero Teixeira ◽  
Margarida M. Lima Pompeu ◽  
...  
Keyword(s):  
Cell Population ◽  
Cellular Migration ◽  
Sand Fly ◽  
Leishmania Infection ◽  
Lutzomyia Longipalpis ◽  
Specific Cell ◽  
Air Pouch ◽  
Leukocyte Accumulation ◽  
Pool Model ◽  
Sand Fly Vectors

Recruitment of a specific cell population after Leishmania infection can influence the outcome of the disease. Cellular migration in response to Leishmania or vector saliva has been reported in air pouch model, however, cellular migration induced by Leishmania associated with host's blood and vector saliva in this model has not been described. Herein we investigated cellular migration into air pouch of hamster after stimulation with combination of L. chagasi and host's blood and Lutzomyia longipalpis saliva. Migration induced by saliva was 3-fold more than those induced by L. chagasi alone. Additionally, L. chagasi associated with blood and saliva induced significantly even more leukocytes into air pouch than Leishmania alone. L. chagasi recruited a diverse cell population; however, most of these cells seem to have not migrated to the inflammatory exudate, remaining in the pouch lining tissue. These results indicate that L. chagasi can reduce leukocyte accumulation to the initial site of infection, and when associated with vector saliva in the presence of blood components, increase the influx of more neutrophils than macrophages, suggesting that the parasite has developed a strategy to minimize the initial inflammatory response, allowing an unlimited progression within the host. This work reinforces the importance of studies on the salivary components of sand fly vectors of leishmaniasis in the transmission process and the establishment of the infection.

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