Cognitive Behavioral Performance of Untreated Depressed Patients with Mild Depressive Symptoms

Objectives: To determine factors impact on the relapse in depressed patients treated with Cognitive Behavioral Therapy (CBT) during one year follow-up. Materials and Methods: 80 depressed patients divided into two groups, group 1: included 40 patients treated with CBT; group 2: 40 patients on amitriptyline. Non-randomized controlled clinical trial, opened, longiditual and prospective research. Results and Conclusions: relapse rate after CBT during 1 year follow-up is 10% (compared to 25% in control group), related factors to relapse rate in depression after CBT are age and education. Shared predictors between 2 groups are severity and recurrence of depression. Key words: Depression, relapse, Cognitive Behavioral Therapy (CBT)

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Cognitive Behavioral Therapy, Ketamine, and Combination Treatment for Depression: Impressions of Credibility in Participants with Self-Reported Depressive Symptoms

Journal of Psychoactive Drugs ◽

10.1080/02791072.2021.1912863 ◽

2021 ◽

pp. 1-11

Author(s):

Mitch Earleywine ◽

Brianna R. Altman ◽

Joseph De Leo

Keyword(s):

Depressive Symptoms ◽

Cognitive Behavioral Therapy ◽

Combination Treatment ◽

Behavioral Therapy ◽

Cognitive Behavioral

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Agomelatine Increases BDNF Serum Levels in Depressed Patients in Correlation with the Improvement of Depressive Symptoms

The International Journal of Neuropsychopharmacology ◽

10.1093/ijnp/pyw003 ◽

2016 ◽

Vol 19 (5) ◽

pp. pyw003 ◽

Cited By ~ 38

Author(s):

Giovanni Martinotti ◽

Mauro Pettorruso ◽

Domenico De Berardis ◽

Paola Annunziata Varasano ◽

Gabriella Lucidi Pressanti ◽

...

Keyword(s):

Depressive Symptoms ◽

Serum Levels ◽

Depressed Patients

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The impact of depressive symptoms on response to integrated cognitive behavioral therapy for substance use disorders and intimate partner violence

Advances in Dual Diagnosis ◽

10.1108/add-09-2020-0020 ◽

2021 ◽

Vol ahead-of-print (ahead-of-print) ◽

Author(s):

Lourah M. Kelly ◽

Cory A. Crane ◽

Kristyn Zajac ◽

Caroline J. Easton

Keyword(s):

Intimate Partner Violence ◽

Substance Use ◽

Depressive Symptoms ◽

Cognitive Behavioral Therapy ◽

Treatment Response ◽

Partner Violence ◽

Behavioral Therapy ◽

Intimate Partner ◽

Cognitive Behavioral ◽

Content Type

Purpose Past studies demonstrated the efficacy of integrated cognitive-behavioral therapy (CBT) for substance use disorder (SUD) and intimate partner violence (IPV) as well as high rates of depressive symptoms in this population. However, little is known about how depressive symptoms impact treatment outcomes. The authors hypothesized that integrated CBT, but not standard drug counseling (DC), would buffer the negative effects of depressive symptoms on treatment response. Design/methodology/approach A secondary analysis of a randomized trial compared men assigned to 12 weeks of integrated CBT for SUD and IPV (n = 29) to those in DC (n = 34). Findings Most (60%) of the sample reported any depressive symptoms. Controlling for baseline IPV, reporting any depressive symptoms was associated with more positive cocaine screens during treatment. Among men with depressive symptoms, integrated CBT but not DC was associated with fewer positive cocaine screens. Controlling for baseline alcohol variables, integrated CBT and depressive symptoms were each associated with less aggression outside of intimate relationships (family, strangers, etc.) during treatment. For men without depressive symptoms, integrated CBT was associated with less non-IPV aggression compared to DC. Effects were not significant for other substances, IPV, or at follow-up. Research limitations/implications This study found some evidence for differential response to CBT by depressive symptoms on cocaine and aggression at end of treatment, which did not persist three months later. Future studies should explore mechanisms of integrated CBT for SUD and IPV, including mood regulation, on depressive symptoms in real-world samples. Practical implications Integrated CBT buffered depressive symptoms’ impact on cocaine use, yet only improved non-IPV aggression in men without depressive symptoms. Originality/value Although integrated CBT’s efficacy for improving SUD and IPV has been established, moderators of treatment response have not been investigated.

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Pattern of Changes during Treatment: A Comparison between a Positive Psychology Intervention and a Cognitive Behavioral Treatment for Clinical Depression

The Spanish Journal of Psychology ◽

10.1017/sjp.2017.44 ◽

2017 ◽

Vol 20 ◽

Cited By ~ 3

Author(s):

Irene Lopez-Gomez ◽

Covadonga Chaves ◽

Gonzalo Hervas ◽

Carmelo Vazquez

Keyword(s):

Depressive Symptoms ◽

Positive Psychology ◽

Repeated Measures ◽

Behavioral Treatment ◽

Mixed Model ◽

Well Being ◽

Clinical Depression ◽

Cognitive Behavioral ◽

Cognitive Behavioral Treatment ◽

Gradual Improvement

AbstractResearch on psychotherapy has traditionally focused on analyzing changes between the beginning and the end of a treatment. Few studies have addressed the pattern of therapeutic change during treatment. The aim of this study was to examine the pattern of changes in clinical and well-being variables during a cognitive behavioral therapy (CBT) program compared with an integrative positive psychology interventions program for clinical depression IPPI-D. 128 women with a diagnosis of major depression or dysthymia were assigned to the CBT or PPI group. A measure of depressive symptoms (i.e., Beck Depression Inventory) and well-being (i.e., Pemberton Happiness Index) were administered four times: at the beginning and end of the treatment, as well as during treatment (at sessions 4 and 7). Through mixed-model repeated measures ANOVAs, both depressive symptoms (p < .001, partial η2 = .52) and well-being (p < .001, partial η2 = .29) showed a significant improvement through the four assessment times. No significant interactions between time and treatment modality were found (ps > .08). The percentage of improvement in depressive symptoms in the first treatment period was higher than in the later ones (ps < .005). On the contrary, well-being showed a more gradual improvement (p = .15). These results highlight the importance of assessing the pattern of changes in symptoms and well-being separately.

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Depression in Geriatric Inpatients: Correlations with Nutritional State and Cognitive Functions

European Psychiatry ◽

10.1016/j.eurpsy.2016.01.1723 ◽

2016 ◽

Vol 33 (S1) ◽

pp. S472-S472

Author(s):

I. Bonfitto ◽

G. Moniello ◽

L. Ariano ◽

M. Pascucci ◽

M.D. Zanasi ◽

...

Keyword(s):

Cognitive Impairment ◽

Depressive Symptoms ◽

Nutritional Status ◽

Rating Scale ◽

Assessment Tool ◽

Mini Nutritional Assessment ◽

Average Score ◽

Depressed Patients ◽

Increased Risk ◽

Geriatric Inpatients

BackgroundAlthough the prevalence of malnutrition is relatively low among elderly people, the risk increases significantly among inpatients and even more in those with mental deterioration.AimsTo evaluate the possible association between the severity of depressive symptoms, the nutritional status and the cognitive decline in a sample of geriatric inpatients.MethodsFifty-one geriatric inpatients completed the following tests:– Hamilton Depression Rating Scale (HAM-D), to assess the severity of depressive symptoms;– Mini Nutritional Assessment (MNA), as a nutrition screening and assessment tool;– Mini Mental State Examination (MMSE), to assess the cognitive impairment.ResultsThere is a negative proportional relationship between HAM-D and MMSE scores (P = 0.001) and between HAM-D and MNA scores (P = 0.023). Depressed patients found to have a greater cognitive impairment and a worse nutritional status. Considering a HAM-D cut-off point of 14, distinguishing mild than moderate depression, it shows a significant correlation with the MNA scores (P = 0.008). Patients with HAM-D scores ≥ 14 have an average MNA score of 19.8, while patients with HAM-D scores < 14 have an MNA average score of 23.6. Euthymic or mildly depressed patients are not at risk of malnutrition, while those with moderate or severe depression have an increased risk of malnutrition.ConclusionsOur study shows significant correlations between the severity of depressive symptoms and the risk of malnutrition or cognitive impairment. A mild depression state does not seem to be associated with an increased risk of malnutrition.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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L-tryptophan and depressive illness

Drug and Therapeutics Bulletin ◽

10.1136/dtb.10.19.75 ◽

1972 ◽

Vol 10 (19) ◽

pp. 75-76

Keyword(s):

Depressive Symptoms ◽

Depressive Illness ◽

Accurate Prediction ◽

Psychiatric Clinic ◽

Contributory Factor ◽

Detailed Knowledge ◽

Depressed Patients ◽

The Brain ◽

Low Rate

Some drugs which lower the concentration of amines in brain may produce depressive symptoms in man. An example of such a drug is reserpine which has been shown to lower the concentration of 5-hydroxytryptamine (5HT) in the brain.1 Recent studies of depressive illnesses suggest that, in some depressed patients, the cerebral content of 5HT (as reflected by CSF metabolites) is low, probably due more to a low rate of synthesis2 than to increased degradation.3 If reduced brain-5HT is a contributory factor in some depressive illnesses, restoring normal concentrations by promoting synthesis or reducing degradation should ameliorate the illness. However, evidence inconsistent with this hypothesis already exists.4 Furthermore, lack of detailed knowledge of the function of 5HT in the neurones which contain it makes accurate prediction from the animal laboratory to the psychiatric clinic difficult.

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