A Common Profile of Disordered Angiogenic Factor Production and the Exacerbation of Inflammation in Early Preeclampsia, Late Preeclampsia, and Intrauterine Growth Restriction

Preeclampsia is the worldwide leading cause of fetomaternal morbidity and mortality which involves the placental dysfunction. A poor placentation and formed of non-dilated spiral artery caused utero-placental circulation insufficiency, resulted in inadequate supply of nutrients and oxygen to support normal aerobic growth of the fetus. Apium graveolens or celery has been widely known as antioxidant, antiinflammation and antihypertensive with flavonoid-apigenin as main active compound. Apigenin can inhibit TNF-α, HIF-1α and nitric oxide blocking as major pathophysiological pathway of preeclampsia. This study was aimed to find how the Apium graveolens can improve intrauterine growth and its correlation with suppression of anti-angiogenic factor sFlt-1 in anti-Qa2 preeclampsia animal model. Twenty female BALB/c Mus musculus were divided into 4 groups: control, anti-Qa2 and anti-Qa2 with 500 and 1000 mg/kgBW celery herbs extract. The fetal weights and lengths, placental weights and serum sFlt-1 levels were measured and analyzed with One Way ANOVA and further tested with Least Significance Difference in 95% confidence interval. The result showed a difference between control and treatments group (p≤0.05) with 1000 mg/kgBW significantly increase intrauterine growth and decrease sFlt-1, then there is a negative correlation between intrauterine weight and serum sFlt-1. This study suggests that celery herbs extract (CHE) has an apigenin-flavonoid compound which can prevent intrauterine growth restriction (IUGR) via suppression of antiangiogenic factor production in preeclampsia mice model.

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The Role of the Anti-Angiogenic Factor Endostatin in Intrauterine Growth Restriction

Journal of the Society for Gynecologic Investigation ◽

10.1016/j.jsgi.2005.01.006 ◽

2005 ◽

Vol 12 (3) ◽

pp. 195-197 ◽

Cited By ~ 8

Author(s):

Ariadne Malamitsi-Puchner ◽

Theodora Boutsikou ◽

Emmanuel Economou ◽

Evangelos Makrakis ◽

Zoe Iliodromiti ◽

...

Keyword(s):

Intrauterine Growth Restriction ◽

Growth Restriction ◽

Angiogenic Factor ◽

Intrauterine Growth

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161. PATERNAL AND FETAL SINGLE NUCLEOTIDE POLYMORPHISMS IN KDR GENE ASSOCIATE WITH PREECLAMPSIA AND INTRAUTERINE GROWTH RESTRICTION

Reproduction Fertility and Development ◽

10.1071/srb09abs161 ◽

2009 ◽

Vol 21 (9) ◽

pp. 79

Author(s):

P. H. Andraweera ◽

S. D. Thompson ◽

R. C. Nowak ◽

V. J. Zhang ◽

G. A. Dekker ◽

...

Keyword(s):

Pregnancy Complications ◽

Intrauterine Growth Restriction ◽

Neonatal Morbidity ◽

Growth Restriction ◽

Angiogenic Factor ◽

Nucleotide Polymorphisms ◽

Chi Square ◽

Ongoing Research ◽

Intrauterine Growth ◽

Placental Angiogenesis

Introduction: Preeclampsia (PE) and intrauterine growth restriction (IUGR) together contribute to maternal and neonatal morbidity and mortality. Abnormal placental angiogenesis is implicated in these pregnancy complications. KDR is the main receptor for vascular endothelial growth factor, a potent angiogenic factor which regulates placental angiogenesis. Derangements in KDR expression are known to result in abnormal angiogenesis. We aimed to determine whether polymorphisms in KDR gene (KDR T604C and KDR C1192C) are associated with PE and IUGR. Methods: 1169 nulliparous pregnant women and their partners were recruited prospectively at the Lyell McEwin Hospital and women monitored throughout pregnancy. PE and IUGR were classified using strict guidelines. Uncomplicated pregnancies were deemed controls. Peripheral blood was collected from couples and cord blood collected at delivery. DNA extraction from buffy coats and genotyping were performed at the Australian Genome Research Facility using the Sequenom MassARRAY system. Genotypes for PE (n=63) and IUGR (n=94) were compared with controls (n=373) and analysed using ANOVA and Chi Square. Odds Ratios (OR) were calculated. Results: Paternal and neonatal KDR T604C were associated with PE (p=0.028, OR=1.9, 95%CI=1.08–3.34 and p=0.008, OR=2.5, 95%CI=1.3–4.78). Paternal and neonatal KDR T604C were associated with IUGR (p=0.005, OR=2.01, 95%CI=1.24–3.25 and p=0.01, OR=1.15, 95% CI=1.22–3.79). Neonates with KDR T604C CC genotype were 144.5g lighter than those with the TT genotype (p=0.05). Mean customised birth weight centile was 8.7 lower for fathers with KDR T604C CC genotype compared to CT (p=0.041). KDR C1192T SNP was not associated with outcome. Conclusion: Our results suggest that KDR T604C polymorphism is associated with both PE and IUGR. We are the first to demonstrate an association between paternal KDR polymorphisms and pregnancy complications. Paternal genes acting via the placenta appear to contribute to the risk of PE and IUGR. Ongoing research will determine the role of these polymorphisms in placental angiogenesis.

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Arterial stiffness in women who subsequently developed isolated intrauterine growth restriction and preeclampsia

Ultraschall in der Medizin - European Journal of Ultrasound ◽

10.1055/s-0033-1354933 ◽

2013 ◽

Vol 34 (S 01) ◽

Author(s):

A Brückmann ◽

C Seeliger ◽

E Schleußner ◽

D Schlembach

Keyword(s):

Arterial Stiffness ◽

Intrauterine Growth Restriction ◽

Growth Restriction ◽

Intrauterine Growth

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Pathological features of the sequence in pregnant women with delayed fetal growth

HEALTH OF WOMAN ◽

10.15574/hw.2019.140.50 ◽

2019 ◽

pp. 50-54

Author(s):

V.O. Golyanovskiy ◽

◽

Ye.O. Didyk ◽

Keyword(s):

Pregnant Women ◽

Intrauterine Growth Restriction ◽

Normal Development ◽

Intrauterine Infection ◽

Normal Pregnancy ◽

Growth Restriction ◽

Control Group ◽

Intrauterine Growth ◽

Increased Risk ◽

Infection And Inflammation

Pregnant women with intrauterine growth restriction (IUGR) have an increased risk of adverse perinatal and long-term complications compared with the birth of children with normal body weight. Thus, IUGR is one of the main challenges for the global health system, especially in poor and developing countries. Morpho-functional studies of the placentas help in determining the causes of IUGR, and therefore, timely prevent complications in pregnant women with IUGR. The objective: The purpose of this study is to investigate various morphometric and pathomorphological changes in the placenta, including inflammatory, in cases of IUGR, and to establish a correlation of these results with the etiology and complications for the fetus. Materials and methods. In the current study, 54 placentas of the fetuses with IUGR (the main group) were compared with 50 placentas of the fetuses with normal development (control group). The criteria for the inclusion of IUGR were gestational age more than 30 weeks and all fetuses with a weight less than 10th percentile for this period of pregnancy. The placenta material was studied pathomorphologically with laboratory screening for infection and inflammation. Similarly, the results were determined for placentas of the fetuses with normal development compared to placentas with IUGR. Results. The placenta study showed the presence of calcification in the case of IUGR, as well as in the case of prolonged pregnancy. However, calcification of the placenta in the case of IUGR was more progressive compared with placenta in the normal pregnancy. In addition, the presence of intrauterine infection and inflammation was observed, which could also lead to an adverse outcome for the further progression of pregnancy with IUGR. Conclusion. A comparative macro- and microscopic pathomorphological study of the placentas in the two groups has shown a significant increase in the pathological changes in all the anatomical structures of the fetuses with IUGR. Key words: Intrauterine growth restriction (IUGR), fetal weight, pathomorphological changes of the placenta.

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