Admixture mapping in the Hispanic Community Health Study/Study of Latinos reveals regions of genetic associations with blood pressure traits

Introduction: Evidence regarding the associations between accelerometer-measured moderate-vigorous physical activity (MVPA) and cardiovascular health (CVH) indicators among Hispanic/Latino adults are unavailable. Methods: Examined cross-sectional data from 12,008 Hispanic/Latino adults aged 18–74 years participating in the Hispanic Community Health Study/Study of Latinos. Accelerometer-measured MVPA was assessed categorically and dichotomously per 2008 PA guidelines. Adverse and ideal CVH indicators were determined by standard cut-points for blood glucose, total cholesterol, blood pressure, body mass index (BMI), and smoking. A composite of low CV risk, defined as achieving all ideal CVH indicators, was included. Adjusted Poisson regression models and complex survey design methods were used for all analyses. Results: Compared to high MVPA, lower MVPA categories were associated with higher prevalence of all adverse CVH indicators, except hypertension, and with lower prevalence of low CV risk and ideal blood glucose, blood pressure, and BMI. Similarly, non-adherence to PA guidelines was associated with a higher prevalence of diabetes (16%), hypercholesterolemia (9%), obesity (28%), and smoking (9%); and lower prevalence of low CV risk (24%), ideal blood glucose (6%), ideal blood pressure (6%), and ideal BMI (22%). Conclusion: Overall, high accelerometer-measured MVPA and meeting PA guidelines were associated with favorable CVH in Hispanic/Latino adults.

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Social and built neighborhood environments and blood pressure 6 years later: Results from the hispanic community health study/study of latinos and the SOL CASAS ancillary study

Social Science & Medicine ◽

10.1016/j.socscimed.2021.114496 ◽

2021 ◽

pp. 114496

Author(s):

Kimberly L. Savin ◽

Scott C. Roesch ◽

Eyal Oren ◽

Jordan A. Carlson ◽

Matthew A. Allison ◽

...

Keyword(s):

Blood Pressure ◽

Community Health ◽

Health Study ◽

Ancillary Study ◽

Hispanic Community ◽

Neighborhood Environments

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0025 ADMIXTURE MAPPING OF SLEEP APNEA PHENOTYPES IN HISPANIC COMMUNITY HEALTH STUDY / STUDY OF LATINOS (HCHS/SOL)

SLEEP ◽

10.1093/sleepj/zsx050.024 ◽

2017 ◽

Vol 40 (suppl_1) ◽

pp. A9-A10

Author(s):

H Wang ◽

BE Cade ◽

R Saxena ◽

T Sofer ◽

S Redline ◽

...

Keyword(s):

Sleep Apnea ◽

Community Health ◽

Health Study ◽

Admixture Mapping ◽

Hispanic Community

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Abstract MP37: Association of Acculturation With Six-year Change in Systolic Blood Pressure Across Diverse Hispanic/Latino Background Groups, the Hispanic Community Health Study/Study of Latinos, 2008-2017

Circulation ◽

10.1161/circ.141.suppl_1.mp37 ◽

2020 ◽

Vol 141 (Suppl_1) ◽

Author(s):

Tali Elfassy ◽

Neil Schneiderman ◽

Tatjana Rundek ◽

Leopoldo Raij ◽

Asmi Panigrahi ◽

...

Keyword(s):

Blood Pressure ◽

Systolic Blood Pressure ◽

Community Health ◽

Puerto Rican ◽

Central American ◽

Health Study ◽

Foreign Born ◽

Potential Health ◽

Hispanic Community

Introduction: Among US Hispanics/Latinos, greater acculturation to US society is associated with higher blood pressure. However, the extent to which this relationship varies across diverse Hispanic/Latino groups is unclear. Objectives: To determine whether acculturation is differentially associated with six-year change in systolic blood pressure (SBP) across Hispanic/Latino groups. Methods: The Hispanic Community Health Study/Study of Latinos is a prospective population-based study of diverse Hispanics/Latinos aged 18-74 years from four US communities. Acculturation at baseline (2008-2011) was defined by the Short Acculturation Scale for Hispanics (SASH) social and language scales (low, medium, or high acculturation) and nativity/duration of US residence (foreign-born with < 10 or ≥ 10 years of US residence, or US born-not including Puerto Rico). The average of three seated SBP measurements was used; difference in SBP from baseline to follow-up (2014-2017) was calculated in 7,836 adults free from hypertension at baseline (SBP < 140 mmHg; diastolic blood pressure < 90 mmHg; and not taking hypertension medication). Using linear regression models accounting for the complex survey design and adjusted for baseline age, sex, education, income, body mass index, years of follow-up, and hypertension medication at follow-up, we estimated the association of each measure of acculturation with change in SBP. Significant interactions between Hispanic/Latino group and measures of acculturation led to stratified models (SASH interaction p=0.01 for social; p=0.28 for language; and nativity/duration of US residence US interaction, p=0.05). Results: Mean baseline age was 36.7 years (SE: 0.23) and 51.7% were women (SE: 0.77). After an average follow-up of 6.2 years (SE: 0.02), mean change in SBP was 2.01 mmHg (SE: 0.20). Among individuals of Central American background, high vs. low SASH language was associated with +3.21 mmHg SBP increase (95% CI: 0.19, 6.24) and being US born vs. foreign-born < 10 years in US was associated with +5.31 mmHg SBP increase (95% CI: 2.10, 8.53). Among individuals of Puerto Rican background, those with ≥ 10 vs. < 10 years in the US 50 states had a 5.67 mmHg lower increase in SBP (95% CI: -9.85, -1.50). Associations between measures of acculturation and changes in SBP were not significant in other groups (i.e. Cubans, Dominicans, and South Americans), but did suggest a greater SBP increase with greater acculturation among Mexican background individuals (e.g. high vs. low SASH social β=1.67, 95% CI: -0.19, 3.52, p=0.08). Conclusions: Greater acculturation was associated with a greater SBP increase among those of Central American background but a lower SBP increase among individuals of Puerto Rican background. These findings show that consideration of Hispanic/Latino group is warranted when assessing potential health effects of acculturation.

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Abstract P246: Dietary Minerals and Metabolic Syndrome: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Circulation ◽

10.1161/circ.137.suppl_1.p246 ◽

2018 ◽

Vol 137 (suppl_1) ◽

Author(s):

Catherine M Bulka ◽

Martha L Daviglus ◽

Daniela Sotres-Alvarez ◽

Ramon A Durazo-Arvizu ◽

Yasmin Mossavar-Rahmani ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Community Health ◽

High Blood Pressure ◽

Abdominal Obesity ◽

Fasting Glucose ◽

Health Study ◽

Hispanic Community ◽

Copper Manganese ◽

High Fasting Glucose

Introduction: Minerals play an integral role in lipid and carbohydrate metabolism and defense against oxidative damage, and thus mineral-poor diets may be an important risk factor for cardiometabolic disease. Little is known about the relationship between dietary mineral intake and metabolic health in Hispanics/Latinos - the largest ethnic minority in the U.S. Hypothesis: Individuals consuming less than recommended amounts of certain minerals may have a greater burden of metabolic syndrome, independent of individual-level risk factors. Methods: We studied 15,051 Hispanic/Latino individuals, aged 18-74 years, from the Hispanic Community Health Study/Study of Latinos, a population-based epidemiologic study of adults enrolled from 4 U.S. communities in 2008-2011. Daily intakes of selected minerals (copper, manganese, selenium, and zinc) from up to two dietary recalls were averaged, and combined with self-reported supplemental intakes. Copper, selenium, and zinc intake levels were dichotomized at the estimated average requirement (EAR); for manganese, the adequate intake (AI) was used as a cutoff point as an EAR has not been established. Metabolic syndrome and its component abnormalities were defined per the harmonized American Heart Association/National Heart, Lung, and Blood Institute criteria as at least 3 of the following 5 criteria: high blood pressure, high triglycerides, low HDL cholesterol, high fasting glucose, or abdominal obesity. Associations of mineral intakes with prevalent metabolic syndrome and its individual components were evaluated using logistic regression models accounting for the complex sampling design of the study. Results: Intakes of copper, manganese, selenium, and zinc were below the EAR/AI in 15%, 29%, 4%, and 13% of individuals, respectively. Copper intake below the EAR was positively associated with metabolic syndrome (OR: 1.23, 95% CI: 1.05-1.44) after adjustment for energy intake, age, gender, and Hispanic/Latino background, and was primarily driven by an association with high blood pressure (1.24, CI: 1.04-1.47). Manganese intake below the AI was also associated with metabolic syndrome (1.16, CI: 1.01-1.32), with the strongest associations observed for high fasting glucose levels (1.20, CI: 1.04-1.38) and abdominal obesity (1.19, CI: 1.05-1.36). Conclusion: Consuming less than the recommended amounts of copper and manganese was associated with a greater prevalence of metabolic syndrome. Future prospective studies are needed to confirm the importance of achieving copper and manganese adequacy and synergistic aspects of foods containing these minerals for optimal cardiometabolic health.

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Abstract 10957: Association of Insulin Resistance and Dysglycemia With Components of Blood Pressure: A Study From the Hispanic Community Health Study/Study of Latinos

Circulation ◽

10.1161/circ.130.suppl_2.10957 ◽

2014 ◽

Vol 130 (suppl_2) ◽

Author(s):

Natalie A Bello ◽

Brian Claggett ◽

Fatima Rodriguez ◽

Jianwen Cai ◽

Ashley Moncrieft ◽

...

Keyword(s):

Insulin Resistance ◽

Blood Pressure ◽

Steady State ◽

Community Health ◽

Health Study ◽

Large Artery ◽

Small Artery ◽

Hispanic Community ◽

Artery Disease ◽

Pulsatile Load

Background: Data are conflicting regarding the extent to which insulin resistance or dysglycemia contribute to the development of elevated blood pressure (BP). Therefore, we examined whether these metabolic abnormalities are associated with distinct BP components, including measures of pulsatile versus steady state load (surrogates for large and small artery disease) in a large community-based cohort. Methods: We studied 10,720 non-diabetic participants from 4 U.S. sites in the Hispanic Community Health Study / Study of Latinos who were free of cardiovascular disease and not on any anti-hypertensive medications. We used linear regression for complex survey sampling and non-parametric spline models to examine the relation of insulin resistance (HOMA-IR) and dysglycemia (HbA1c) with components of BP (systolic, diastolic, pulse pressure [PP, reflecting pulsatile load], and mean arterial pressure [MAP, reflecting steady state load]) while adjusting for established clinical correlates of BP. Results: The target population mean age was 38 years (s.e. 0.22) and included 52% women, 38% with pre-diabetes, 35% obese, and 9% with untreated hypertension. All BP component measures were higher in pre-diabetes than non-diabetes. In multivariable analyses, HOMA-IR was significantly associated with increase in all BP components (P<0.01 for all), including both PP and MAP, in the setting of both pre-diabetes and particularly non-diabetes (Figure). By contrast, HbA1c was not significantly associated with increase in any BP component. Conclusion: In a large population of non-diabetic Hispanic/Latino adults, insulin resistance (rather than dysglycemia per se) is related to increase in all BP components including measures of both pulsatile load (representing large artery disease) and steady state load (representing small artery disease). These findings may have implications for interventions aimed at preventing large and small vessel disease in the community.

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