Abstract P246: Dietary Minerals and Metabolic Syndrome: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Catherine M Bulka ◽  
Martha L Daviglus ◽  
Daniela Sotres-Alvarez ◽  
Ramon A Durazo-Arvizu ◽  
Yasmin Mossavar-Rahmani ◽  
...  

Introduction: Minerals play an integral role in lipid and carbohydrate metabolism and defense against oxidative damage, and thus mineral-poor diets may be an important risk factor for cardiometabolic disease. Little is known about the relationship between dietary mineral intake and metabolic health in Hispanics/Latinos - the largest ethnic minority in the U.S. Hypothesis: Individuals consuming less than recommended amounts of certain minerals may have a greater burden of metabolic syndrome, independent of individual-level risk factors. Methods: We studied 15,051 Hispanic/Latino individuals, aged 18-74 years, from the Hispanic Community Health Study/Study of Latinos, a population-based epidemiologic study of adults enrolled from 4 U.S. communities in 2008-2011. Daily intakes of selected minerals (copper, manganese, selenium, and zinc) from up to two dietary recalls were averaged, and combined with self-reported supplemental intakes. Copper, selenium, and zinc intake levels were dichotomized at the estimated average requirement (EAR); for manganese, the adequate intake (AI) was used as a cutoff point as an EAR has not been established. Metabolic syndrome and its component abnormalities were defined per the harmonized American Heart Association/National Heart, Lung, and Blood Institute criteria as at least 3 of the following 5 criteria: high blood pressure, high triglycerides, low HDL cholesterol, high fasting glucose, or abdominal obesity. Associations of mineral intakes with prevalent metabolic syndrome and its individual components were evaluated using logistic regression models accounting for the complex sampling design of the study. Results: Intakes of copper, manganese, selenium, and zinc were below the EAR/AI in 15%, 29%, 4%, and 13% of individuals, respectively. Copper intake below the EAR was positively associated with metabolic syndrome (OR: 1.23, 95% CI: 1.05-1.44) after adjustment for energy intake, age, gender, and Hispanic/Latino background, and was primarily driven by an association with high blood pressure (1.24, CI: 1.04-1.47). Manganese intake below the AI was also associated with metabolic syndrome (1.16, CI: 1.01-1.32), with the strongest associations observed for high fasting glucose levels (1.20, CI: 1.04-1.38) and abdominal obesity (1.19, CI: 1.05-1.36). Conclusion: Consuming less than the recommended amounts of copper and manganese was associated with a greater prevalence of metabolic syndrome. Future prospective studies are needed to confirm the importance of achieving copper and manganese adequacy and synergistic aspects of foods containing these minerals for optimal cardiometabolic health.

2020 ◽  
Author(s):  
Diana A. Chirinos ◽  
Maria M. Llabre ◽  
Ronald Goldberg ◽  
Marc Gellman ◽  
Armando Mendez ◽  
...  

<b>Objective: </b>Various organizations have highlighted the need to examine whether abdominal obesity cut-points are appropriate for identification of cardiovascular risk among ethnic minority adults, particularly Hispanic/Latino living in western societies. This study aimed (1) to establish optimal definitions for abdominal obesity among Hispanic/Latinos, and (2) determine the level of agreement between the presence of metabolic syndrome diagnosed by the current Joint Interim Statement (IJS) definition and an updated definition with optimal abdominal obesity cut points. <p><b>Research Design and Methods:</b> The sample included 16,289 adults who self-identified as Hispanic/Latino ages 18-74 years enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Receiving operating characteristic (ROC) curves were used to derive sensitivity and specificity values. The largest sum of sensitivity plus specificity was used to determine appropriate cut-points. </p> <p><b>Results:</b> Among US Hispanic/Latino adults, waist circumference cut points of >102 cm in men (in line with current IJS criteria) and >97 cm (9 points higher than IJS criteria) in women provide optimal discrimination for cardiovascular risk as judged by the presence of coronary heart disease. When using these cut points to create an updated metabolic syndrome definition among women, we found disagreement between our updated definition and the current IJS criteria. The prevalence of the metabolic syndrome was overestimated by about 5% points among women based on IJS criteria when compared to our definition. </p> <p><b>Conclusions: </b>Our results suggest that the current recommendations for waist circumference cut-points may not be appropriate for US Hispanic/Latino women. </p>


2020 ◽  
Author(s):  
Diana A. Chirinos ◽  
Maria M. Llabre ◽  
Ronald Goldberg ◽  
Marc Gellman ◽  
Armando Mendez ◽  
...  

<b>Objective: </b>Various organizations have highlighted the need to examine whether abdominal obesity cut-points are appropriate for identification of cardiovascular risk among ethnic minority adults, particularly Hispanic/Latino living in western societies. This study aimed (1) to establish optimal definitions for abdominal obesity among Hispanic/Latinos, and (2) determine the level of agreement between the presence of metabolic syndrome diagnosed by the current Joint Interim Statement (IJS) definition and an updated definition with optimal abdominal obesity cut points. <p><b>Research Design and Methods:</b> The sample included 16,289 adults who self-identified as Hispanic/Latino ages 18-74 years enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Receiving operating characteristic (ROC) curves were used to derive sensitivity and specificity values. The largest sum of sensitivity plus specificity was used to determine appropriate cut-points. </p> <p><b>Results:</b> Among US Hispanic/Latino adults, waist circumference cut points of >102 cm in men (in line with current IJS criteria) and >97 cm (9 points higher than IJS criteria) in women provide optimal discrimination for cardiovascular risk as judged by the presence of coronary heart disease. When using these cut points to create an updated metabolic syndrome definition among women, we found disagreement between our updated definition and the current IJS criteria. The prevalence of the metabolic syndrome was overestimated by about 5% points among women based on IJS criteria when compared to our definition. </p> <p><b>Conclusions: </b>Our results suggest that the current recommendations for waist circumference cut-points may not be appropriate for US Hispanic/Latino women. </p>


2018 ◽  
Vol 29 (2) ◽  
pp. 6-10
Author(s):  
Khan MMR ◽  
Sana NK ◽  
PM Basak ◽  
BC Sarker ◽  
M Akhtarul Islam ◽  
...  

Background: Metabolic syndrome confers the risk of developing acute myocardial infarction which is the most common form of coronary heart disease and the single most important cause of premature death worldwide. The frequency and association of different components of metabolic syndrome on AMI are not well understood and has not been well evaluated.Objective: The aim of this study was to assess the components of the metabolic syndrome and its association with AMI patients. This study will help in awareness building in reducing AMI by early detection of components of metabolic syndrome.Patients and methods: This was a prospective observational study consisted of 325 AMI patients who were aged >20 years. Patients with first time AMI arriving in CCU of Rajshahi medical college during the period of 2012-2014, were included. Data were collected through interview, clinical examination, and laboratory tests within 24 hrs of AMI. Five components of metabolic syndrome were defined according to criteria set by modified NCEP ATP III (according to ethnic variation).Results: In AMI patients (n=325), no metabolic components were in 24 (7.4%) patients, one in 53 (16.3%), 2 components in 91(28.0%), 3 components were in 61(18.8%), 4 in 67(20.6%) and all 5 components were in 29 (8.9%) patients. In this study, there was no component in 7.4% of AMI patients, at least 1 component was 92.6%, at least 2 components were 76.3%, at least 3 components were 48.3%, at least 4 components were 29.5% and at least 5 components were 8.9%. The Metabolic syndrome was 48.3% (n=157). Among metabolic syndrome (≥3 components) in AMI (n=157, 48.3%) 4 components (20.6%) were more, next was 3 components (18.8%) and than 5 components (8.9%). Overall frequencies of components in acute myocardial infarction (n=325) were in order of abdominal obesity (54.8%) > high blood pressure (54.5%) > high FPG (54.2%) > Triglyceride (46.2%) and low HDL-C (46.2%) in acute myocardial infarction. Highest percentage was observed in abdominal obesity (54.8%) followed by high blood pressure (54.5%) and FPG (54.2%).TAJ 2016; 29(2): 6-10


Diabetes Care ◽  
2014 ◽  
Vol 37 (8) ◽  
pp. 2391-2399 ◽  
Author(s):  
Gerardo Heiss ◽  
Michelle L. Snyder ◽  
Yanping Teng ◽  
Neil Schneiderman ◽  
Maria M. Llabre ◽  
...  

2015 ◽  
Vol 25 (7) ◽  
pp. 480-485 ◽  
Author(s):  
Maria M. Llabre ◽  
William Arguelles ◽  
Neil Schneiderman ◽  
Linda C. Gallo ◽  
Martha L. Daviglus ◽  
...  

2019 ◽  
Vol 7 (6) ◽  
Author(s):  
Kingsley K. Anya ◽  
Godwin O. Okoro ◽  
Charles C. Onyenekwe ◽  
Samuel Ayobami Fasogbon ◽  
Ahmed O. Adebayo

Metabolic impairments could be seen at any point in human development. Although emphasis has been placed on older adults but it could be encountered in any age brackets. The aim of this study was to compare prevalence rates using different definitions of Metabolic syndrome (MetS) among students of Faculty of Health Sciences and Technology (FHST) in Ebonyi State University (EBSU), Abakaliki.  This was a cross-sectional study involving 80 students (28 male students and 52 female students) recruited from among students of FHST in EBSU, Abakaliki, Ebonyi State, Nigeria. MetS was defined in three different ways [by International Diabetes Federation (IDF), National Cholesterol Education Program—Adult Treatment Panel III (NCEP-ATPIII), or World Health Organization (WHO) criteria]. Prevalence was found to be 6.3%, 2.5% and 7.5% using NCEP-ATP III, WHO, and IDF definitions respectively.  The most common MetS components among female students using the NCEP-ATP III criteria were high blood pressure (5.8%) and abdominal obesity (5.8%), whilst low HDL-C concentrations, high blood pressure and abdominal obesity were most common among male students (7.1 % for each component mentioned). According to WHO, abdominal obesity (7.1%) and hyperglycaemia (7.1%) were the most common MetS components among male students. The most common MetS components among participants using the IDF criteria were abdominal obesity and high blood pressure. While some participants did not meet the MetS criteria of the NCEP-ATP III, WHO and IDF criteria (50%), many had one (30%) or two (13.8%) components and may be at risk of developing the syndrome in the future. The mean values of the risk factors  used as criteria for the diagnosis of MetS were relatively normal in the study population thereby masking the presence of MetS, thus showing that the prevalence of MetS may gradually increase undetected unless individual members of the study population are subjected to laboratory investigation using different criteria for diagnosis of MetS. Therefore, traditional risk factors might be late markers for diagnosis of MetS since findings from this study showed that MetS was only detected in participants that already had it.


2020 ◽  
Vol 27 (2) ◽  
pp. 188-199
Author(s):  
Tasneem Khambaty ◽  
Neil Schneiderman ◽  
Maria M. Llabre ◽  
Tali Elfassy ◽  
Ashley E. Moncrieft ◽  
...  

2019 ◽  
Vol 15 ◽  
pp. 100950 ◽  
Author(s):  
Brian T. Joyce ◽  
Donghong Wu ◽  
Lifang Hou ◽  
Qi Dai ◽  
Sheila F. Castaneda ◽  
...  

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ying Zheng ◽  
Zengshuo Xie ◽  
Jiayong Li ◽  
Chen Chen ◽  
Wenting Cai ◽  
...  

Abstract Background Recent studies have reported the effects of metabolic syndrome (MetS) and its components on atrial fibrillation (AF), but the results remain controversial. Therefore, we performed a meta-analysis to evaluate the relationship between MetS and AF risk. Methods Studies were searched from the Cochrane library, PubMed, and Embase databases through May 2020. Adjusted hazard ratios (HRs) and its corresponding 95% confidence intervals (CIs) were extracted and then pooled by using a random effects model. Results A total of 6 observational cohort studies were finally included. In the pooled analysis, MetS was associated with an increased risk of AF (HR 1.57; 95% CI 1.40–1.77; P < 0.01). And the components of MetS including abdominal obesity (HR 1.37; 95% CI 1.36–1.38; P < 0.01), elevated blood pressure (HR 1.56; 95% CI 1.46–1.66; P < 0.01), elevated fasting glucose (HR 1.18; 95% CI 1.15–1.21; P < 0.01) and low high density cholesterol (HDL) (HR 1.18; 95% CI 1.06–1.32; P < 0.01) was also associated with an increased risk of AF, while high triglyceride (HR 0.99; 95% CI 0.87–1.11, P = 0.82) was not. Conclusions Our present meta-analysis suggested that MetS, as well as its components including abdominal obesity, elevated blood pressure, elevated fasting glucose and low HDL cholesterol were associated with an increase in the risk of AF.


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