scholarly journals Cellular immune responses in peripheral blood lymphocytes of Giardia infected squirrel monkey (Saimiri boliviensis boliviensis) treated with Fenbendazole

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0198497 ◽  
Author(s):  
Pramod N. Nehete ◽  
Gregory Wilkerson ◽  
Bharti P. Nehete ◽  
Sriram Chitta ◽  
Julio C. Ruiz ◽  
...  





Blood ◽  
1973 ◽  
Vol 41 (5) ◽  
pp. 625-633 ◽  
Author(s):  
Roberto Marcolongo ◽  
Nicola Di Paolo

Abstract Five patients with Hodgkin’s disease were treated by transplantation of fetal thymic tissue. Clinical and immunologic studies, carried out for over 5 mo thereafter, revealed a prompt improvement in previously defective cellular immune functions, including a significant rise of absolute lymphocytes in the peripheral blood and a normalization of tuberculin skin sensitivity and of the response of peripheral blood lymphocytes to phytohemagglutinin. It is suggested that fetal thymic transplant into patients with Hodgkin’s disease appears at present the best tool of improving their immunologic deficiency.



1999 ◽  
Vol 70 (1-2) ◽  
pp. 67-83 ◽  
Author(s):  
Christoph Hölscher ◽  
Georg Hasch ◽  
Norbert Joswig ◽  
Uta Stauffer ◽  
Uwe Müller ◽  
...  


1997 ◽  
Vol 56 ◽  
pp. 135
Author(s):  
R. Markova ◽  
R. Argirova ◽  
V. Terzieva ◽  
S. Raleva ◽  
L. Froloshka ◽  
...  


Blood ◽  
2004 ◽  
Vol 103 (8) ◽  
pp. 3084-3092 ◽  
Author(s):  
Siske S. Struik ◽  
Fakhreldin M. Omer ◽  
Katerina Artavanis-Tsakonas ◽  
Eleanor M. Riley

Abstract Whole-blood assays (WBAs) have been successfully used as a simple tool for immuno-epidemiological field studies evaluating cellular immune responses to mycobacterial and viral antigens. Rather unexpectedly, we found very poor cytokine responses to malaria antigens in WBAs in 2 immuno-epidemiological studies carried out in malaria endemic populations in Africa. We have therefore conducted a detailed comparison of cellular immune responses to live (intact) and lysed malaria-infected erythrocytes in WBAs and in peripheral blood mononuclear cell (PBMC) cultures. We observed profound inhibition of both proliferative and interferon-γ responses to malarial antigens in WBAs as compared with PBMC cultures. This inhibition was seen only for malaria antigens and could not be overcome by increasing either antigen concentration or responder cell numbers. Inhibition was mediated by intact erythrocytes and occurred early in the culture period, suggesting that failure of antigen uptake might underlie the lack of T-cell responses. In support of this hypothesis, we have shown that intact uninfected erythrocytes specifically inhibit phagocytosis of infected red blood cells by peripheral blood monocytes. We propose that specific biochemical interactions with uninfected erythrocytes inhibit the phagocytosis of malaria-infected erythrocytes and that this may impede T-cell recognition in vivo. (Blood. 2004; 103:3084-3092)



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