Monocytes Suppress Immune Responses of Peripheral Blood Lymphocytes: Possible Implication of Immature Dendritic Cells

2003 ◽  
pp. 237-242
Author(s):  
M. Yamashita ◽  
Y. Katakura ◽  
S. Matsumoto ◽  
T. Tamura ◽  
K. Teruya ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Immune Responses ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Immature Dendritic Cells

scholarly journals Cellular immune responses in peripheral blood lymphocytes of Giardia infected squirrel monkey (Saimiri boliviensis boliviensis) treated with Fenbendazole

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0198497 ◽  
Author(s):  
Pramod N. Nehete ◽  
Gregory Wilkerson ◽  
Bharti P. Nehete ◽  
Sriram Chitta ◽  
Julio C. Ruiz ◽  
...  
Keyword(s):  
Immune Responses ◽  
Squirrel Monkey ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Cellular Immune Responses ◽  
Saimiri Boliviensis ◽  
Cellular Immune

Long term substitution and specific immune responses after transfer of bovine peripheral blood lymphocytes into severe combined immunodeficient mice

1999 ◽  
Vol 70 (1-2) ◽  
pp. 67-83 ◽  
Author(s):  
Christoph Hölscher ◽  
Georg Hasch ◽  
Norbert Joswig ◽  
Uta Stauffer ◽  
Uwe Müller ◽  
...  
Keyword(s):  
Immune Responses ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Immunodeficient Mice ◽  
Blood Lymphocytes

scholarly journals Reciprocal Activating Interaction between Natural Killer Cells and Dendritic Cells

2002 ◽  
Vol 195 (3) ◽  
pp. 327-333 ◽  
Author(s):  
Franca Gerosa ◽  
Barbara Baldani-Guerra ◽  
Carla Nisii ◽  
Viviana Marchesini ◽  
Giuseppe Carra ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Nk Cells ◽  
Natural Killer ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Cytolytic Activity ◽  
Cell Contact ◽  
Immature Dendritic Cells ◽  
Dc Maturation

We analyzed the interaction between human peripheral blood natural killer (NK) cells and monocyte-derived immature dendritic cells (DC). Fresh NK cells were activated, as indicated by the induced expression of the CD69 antigen, and their cytolytic activity was strongly augmented by contact with lipopolysaccharide (LPS)-treated mature DC, or with immature DC in the presence of the maturation stimuli LPS, Mycobacterium tuberculosis or interferon (IFN)-α. Reciprocally, fresh NK cells cultured with immature DC in the presence of the maturation stimuli strongly enhanced DC maturation and interleukin (IL)-12 production. IL-2–activated NK cells directly induced maturation of DC and enhanced their ability to stimulate allogeneic naive CD4+ T cells. The effects of NK cells were cell contact dependent, although the secretion of IFN-γ and TNF also contributed to DC maturation. Within peripheral blood lymphocytes the reciprocal activating interaction with DC was restricted to NK cells, because the other lymphocyte subsets were neither induced to express CD69, nor induced to mature in contact with DC. These data demonstrated for the first time a bidirectional cross talk between NK cells and DC, in which NK cells activated by IL-2 or by mature DC induce DC maturation.

Comparison of immune responses in inbred lines of chickens toEimeria maximaandEimeria tenella

Parasitology ◽  
1995 ◽  
Vol 111 (2) ◽  
pp. 143-151 ◽  
Author(s):  
J. M. Bumstead ◽  
N. Bumstead ◽  
L. Rothwell ◽  
F. M. Tomley
Keyword(s):  
Immune Responses ◽  
Peripheral Blood ◽  
Primary Infection ◽  
Direct Relationship ◽  
Inbred Lines ◽  
Peripheral Blood Lymphocytes ◽  
Susceptible Line ◽  
Blood Lymphocytes ◽  
Resistant Lines

SUMMARYImmune responses of 4 inbred lines of chickens, that differ in resistance toEimeria maximaandE. tenella, were examined. Significant differences were found inin vitroproliferation of peripheral blood lymphocytes toE. maximasporozoite antigen, the more resistant lines C and 72having higher responses than the more susceptible line 151. These differences existed pre-infection and were enhanced following both primary and a second infection. The proportions of lymphocyte subsets in the peripheral blood following primary infection also differed between lines, with significantly higher percentages of CD8 + and TCR1 + lymphocytes circulating in the more resistant birds. In contrast, there were few differences between lines in either resistance or inin vitroproliferation of peripheral blood lymphocytes toE. tenellasporozoite antigen either pre-infection or following a primary infection. However, after a second infection when there were significant differences in resistance between lines, as measured by oocyst excretion, there were also significant differences in lymphoproliferation with the more resistant lines 151 and 62having higher responses than the more susceptible line C. Thus forE. maximathere is a direct relationship between resistance to infection and lymphoproliferation in response to parasite antigen. This implies that differences in cellular immunity may account for differences in resistance between lines, and since these specific responses are enhanced by infection they may also reflect important immune mechanisms. For the rather less immunogenicE. tenella, the correlation between resistance and lymphoproliferation is not so clear. However, where there were significant differences between lines, i.e. after a second infection, the direct relationship between resistance and lymphoproliferation was upheld.

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