scholarly journals Measles virus genotype D4 strains with non-standard length M-F non-coding region circulated during the major outbreaks of 2011-2012 in Spain

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0199975 ◽  
Author(s):  
Horacio Gil ◽  
Aurora Fernández-García ◽  
María Mar Mosquera ◽  
Judith M. Hübschen ◽  
Ana M. Castellanos ◽  
...  
Keyword(s):  
Standard Length ◽  
Measles Virus ◽  
Coding Region ◽  
Virus Genotype

scholarly journals Complete Genome Sequences of Measles Virus Genotype D8 Isolates from South Korea in 2016

2019 ◽  
Vol 8 (29) ◽  
Author(s):  
You-Jin Kim ◽  
Hae Ji Kang ◽  
Su-Jin Kim ◽  
Hye Min Lee ◽  
Sung Soon Kim
Keyword(s):  
Genetic Diversity ◽  
South Korea ◽  
Complete Genome ◽  
Measles Virus ◽  
Virus Transmission ◽  
Wild Type ◽  
Genome Sequences ◽  
Virus Genotype

The complete genome sequences of three wild-type measles viruses (genotype D8) isolated from patients in South Korea were determined. These are the first reported complete genome sequences of measles viruses obtained from South Korea, and the availability of these sequences will improve our understanding of measles virus transmission and genetic diversity.

Genetic characterization of measles virus genotype D6 subacute sclerosing panencephalitis case, Alberta, Canada

2018 ◽  
Vol 24 (6) ◽  
pp. 720-729 ◽  
Author(s):  
K. Pabbaraju ◽  
K. Fonseca ◽  
S. Wong ◽  
M. W. Koch ◽  
J. T. Joseph ◽  
...  
Keyword(s):  
Measles Virus ◽  
Genetic Characterization ◽  
Subacute Sclerosing Panencephalitis ◽  
Virus Genotype

scholarly journals Novel Measles Virus Genotype, East Timor and Australia

2002 ◽  
Vol 8 (7) ◽  
pp. 735-737 ◽  
Author(s):  
Doris Chibo ◽  
Michaela Riddell ◽  
Michael Catton ◽  
Christopher Birch
Keyword(s):  
Measles Virus ◽  
East Timor ◽  
Virus Genotype

scholarly journals Ongoing African measles virus genotype outbreak in Tel Aviv district since April, Israel, 2012

2012 ◽  
Vol 17 (37) ◽  
Author(s):  
E Kopel ◽  
Z Amitai ◽  
M Savion ◽  
Y Aboudy ◽  
E Mendelson ◽  
...  
Keyword(s):  
World Health Organization ◽  
Measles Virus ◽  
World Health ◽  
European Region ◽  
Virus Genotype ◽  
Tel Aviv ◽  
Measles Outbreak ◽  
The World ◽  
The Mean ◽  
Health Organization

A measles outbreak is affecting the Tel Aviv district, Israel, since April 2012. As of 10 September, 99 cases were confirmed, including 63 (64%) migrants of Eritrean and Sudanese origin. All genotyped cases had the African B3 genotype*. The mean age of migrant and non-migrant cases was 6.0±9.6 and 30.2±24.2 years, respectively (p<0.001). The majority of both migrant and non-migrant cases was unvaccinated. This is the second African measles B3 genotype outbreak within the World Health Organization European region in 2012.

scholarly journals New Measles Virus Genotype Associated with Outbreak, China

2010 ◽  
Vol 16 (6) ◽  
pp. 943-947 ◽  
Author(s):  
Yan Zhang ◽  
Zhengrong Ding ◽  
Huiling Wang ◽  
Liqun Li ◽  
Yankun Pang ◽  
...  
Keyword(s):  
Measles Virus ◽  
Virus Genotype

scholarly journals Molecular genetic analysis of the strain Leningrad-16 used for the production of measles vaccine

2020 ◽  
Vol 97 (2) ◽  
pp. 182-189
Author(s):  
Georgy M. Ignatyev ◽  
Alena V. Atrasheuskaya ◽  
Lidiya L. Sukhanova ◽  
Elena S. Sidorenko ◽  
Nina A. Netesova
Keyword(s):  
Vaccine Strain ◽  
Measles Virus ◽  
Restriction Analysis ◽  
Molecular Genetic ◽  
Molecular Genetic Analysis ◽  
Rt Pcr ◽  
Virus Genotype ◽  
Molecular Genetic Study ◽  
Production Stages ◽  
Pcr Method

Aim. To study the genetic stability of the measles virus strain Leningrad-16 (L-16) used for the production of vaccine at JSC NPO Mikrogen.Materials and methods. A series of production and sowing strains of L-16 (JSC NPO Mikrogen), ready-made series of measles vaccines from various manufacturers, and the strain of measles virus genotype D6 were studied. Molecular genetic study of the strains was performed using RT-PCR followed by restriction analysis and sequencing.Results. The complete genome sequences of the production and sowing strains of L-16 that are used for vaccine production were obtained. The sequence of the vaccine strain was deposited in GenBank. Strain L-16 was confirmed to be genetically stable. The obtained data demonstrated the possibility of using the RT-PCR method with subsequent restriction analysis to confirm the authenticity of the vaccine strain L-16 in finished mono and three component vaccines.Conclusion. The results of the study suggest the applicability of the molecular genetic methods to confirm the authenticity of the studied strains not only at the production stages, but also in the finished series of vaccines.

scholarly journals Genetic Characterizations and Molecular Evolution of the Measles Virus Genotype B3’s Hemagglutinin (H) Gene in the Elimination Era

Viruses ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1970
Author(s):  
Nan Zhou ◽  
Mingma Li ◽  
Yue Huang ◽  
Lu Zhou ◽  
Bei Wang
Keyword(s):  
Positive Selection ◽  
Substitution Rate ◽  
Measles Virus ◽  
Selection Pressure ◽  
Genotypic Diversity ◽  
Nucleotide Substitution Rate ◽  
Effective Population ◽  
Virus Genotype ◽  
Slowing Down ◽  
H Gene

Measles virus (MeV) genotype B3 is one globally significant circulating genotype. Here, we present a systematic description of long-term evolutionary characterizations of the MeV genotype B3’s hemagglutinin (H) gene in the elimination era. Our results show that the B3 H gene can be divided into two main sub-genotypes, and the highest intra-genotypic diversity was observed in 2004. MeV genotype B3’s H gene diverged in 1976; its overall nucleotide substitution rate is estimated to be 5.697 × 10−4 substitutions/site/year, and is slowing down. The amino acid substitution rate of genotype B3’s H gene is also decreasing, and the mean effective population size has been in a downward trend since 2000. Selection pressure analysis only recognized a few sites under positive selection, and the number of positive selection sites is getting smaller. All of these observations may reveal that genotype B3’s H gene is not under strong selection pressure, and is becoming increasingly conservative. MeV H-gene or whole-genome sequencing should be routine, so as to better elucidate the molecular epidemiology of MeV in the future.

Measles Virus Genotype D Wild Strains Suppress Interferon-Stimulated Gene Expression More Potently than Laboratory Strains in SiHa Cells

2016 ◽  
Vol 29 (5) ◽  
pp. 296-306
Author(s):  
Masaru Jinushi ◽  
Soh Yamamoto ◽  
Noriko Ogasawara ◽  
Hideki Nagano ◽  
Shin Hashimoto ◽  
...  
Keyword(s):  
Gene Expression ◽  
Measles Virus ◽  
Virus Genotype ◽  
Siha Cells ◽  
Wild Strains

scholarly journals Measles outbreak spreading from the community to an anthroposophic school, Berlin, 2011

2013 ◽  
Vol 142 (4) ◽  
pp. 789-796 ◽  
Author(s):  
S. GILLESBERG LASSEN ◽  
M. SCHUSTER ◽  
M. STEMMLER ◽  
A. STEINMÜLLER ◽  
D. MATYSIAK-KLOSE ◽  
...  
Keyword(s):  
Poisson Regression ◽  
Measles Virus ◽  
Vaccination Status ◽  
Day School ◽  
Measles Vaccine ◽  
Childhood Immunization ◽  
Virus Genotype ◽  
Routine Childhood ◽  
Measles Outbreak ◽  
Catch Up

SUMMARYBetween April and July 2011 there was an outbreak of measles virus, genotype D4, in Berlin, Germany. We identified 73 case-patients from the community and among students of an anthroposophic school, who participated in a 4-day school trip, as well as their family and friends. Overall, 27% were aged ⩾20 years, 57% were female and 15% were hospitalized. Of 39 community case-patients, 38% were aged ⩾20 years, 67% were female and 63% required hospitalization. Unvaccinated students returning from the school trip were excluded from school, limiting transmission. Within the group of 55 school-trip participants, including 20 measles case-patients, a measles vaccine effectiveness of 97·1% (95% confidence interval 83·4–100) for two doses was estimated using exact Poisson regression. Our findings support school exclusions and the recommendation of one-dose catch-up vaccination for everyone born after 1970 with incomplete or unknown vaccination status, in addition to the two-dose routine childhood immunization recommendation.

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