scholarly journals Risk of adverse treatment outcomes among new pulmonary TB patients co-infected with diabetes in Pakistan: A prospective cohort study

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0207148 ◽  
Author(s):  
Fatima Mukhtar ◽  
Zahid A. Butt
Keyword(s):  
Cohort Study ◽  
Treatment Outcomes ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Pulmonary Tb

scholarly journals Clinical profiles of subclinical disease among pulmonary tuberculosis patients: a prospective cohort study in South Korea

2020 ◽  
Author(s):  
Jinsoo Min ◽  
Chaeuk Chung ◽  
Sung Soo Jung ◽  
Hye Kyeong Park ◽  
Sung-Soon Lee ◽  
...  
Keyword(s):  
Cohort Study ◽  
South Korea ◽  
Treatment Outcomes ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Multivariable Analysis ◽  
Pulmonary Tb ◽  
Cell Counts ◽  
Subclinical Disease ◽  
Active Disease

Abstract Background: Subclinical tuberculosis (TB) is a potential target for public health intervention because its early identification may reduce TB transmission. We aimed to describe the clinical and laboratory findings of subclinical disease among pulmonary TB patients and compared treatment outcomes for subclinical and active diseases.Methods: In this prospective cohort study, we enrolled adult patients aged ≥19 years with pulmonary TB between 2016 and 2018. Subclinical TB was defined as radiographic or microbiologic test results consistent with TB without clinical symptoms. We implemented a two-stage symptom assessment using a predefined TB symptom checklist. Demographic, clinical, and laboratory data were compared between subclinical and active diseases using multivariable binary logistic regression analysis. We evaluated treatment outcomes in the drug-susceptible cohort.Results: Among 420 enrolled patients, 81 (19.3%) had subclinical TB. Multivariable analysis showed that age <65 years was the only variable significantly associated with subclinical disease. Subclinical disease had a significantly lower proportion of acid-fast bacilli smear and culture positivity and multiple lobe involvement compared to active disease. The white blood cell counts, platelet counts, and C-reactive protein levels were significantly higher among patients with active disease than among those with subclinical disease. Among 319 patients with treatment success in the drug-susceptible cohort, six (1.9%) recurrent cases were identified, and all were active disease. Patients with subclinical disease had a higher proportion of favourable outcomes; however, its odds ratio was insignificant.Conclusions: Nearly one-fifth of tuberculosis cases were subclinical in South Korea. Despite its milder clinical presentation and lower level of inflammatory markers, the treatment outcomes of subclinical TB were not significantly different from that of active disease.

scholarly journals Clinical profiles of subclinical disease among pulmonary tuberculosis patients: a prospective cohort study in South Korea

2020 ◽  
Author(s):  
Jinsoo Min ◽  
Chaeuk Chung ◽  
Sung Soo Jung ◽  
Hye Kyeong Park ◽  
Sung-Soon Lee ◽  
...  
Keyword(s):  
Cohort Study ◽  
South Korea ◽  
Treatment Outcomes ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Multivariable Analysis ◽  
Pulmonary Tb ◽  
Cell Counts ◽  
Subclinical Disease ◽  
Active Disease

Abstract Background: Subclinical tuberculosis (TB) is a potential target for public health intervention because its early identification may reduce TB transmission. We aimed to describe the clinical and laboratory findings of subclinical disease among pulmonary TB patients and compared treatment outcomes for subclinical and active diseases. Methods: In this prospective cohort study, we enrolled adult patients aged ≥19 years with pulmonary TB between 2016 and 2018. Subclinical TB was defined as radiographic or microbiologic test results consistent with TB without clinical symptoms. We implemented a two-stage symptom assessment using a predefined TB symptom checklist. Demographic, clinical, and laboratory data were compared between subclinical and active diseases using multivariable binary logistic regression analysis. We evaluated treatment outcomes in the drug-susceptible cohort. Results: Among 420 enrolled patients, 81 (19.3%) had subclinical TB. Multivariable analysis showed that age <65 years was the only variable significantly associated with subclinical disease. Subclinical disease had a significantly lower proportion of acid-fast bacilli smear and culture positivity and multiple lobe involvement compared to active disease. The white blood cell counts, platelet counts, and C-reactive protein levels were significantly higher among patients with active disease than among those with subclinical disease. Among 319 patients with treatment success in the drug-susceptible cohort, six (1.9%) recurrent cases were identified, and all were active disease. Patients with subclinical disease had a higher proportion of favourable outcomes; however, its odds ratio was insignificant. Conclusions: Nearly one-fifth of tuberculosis cases were subclinical in South Korea. Despite its milder clinical presentation and lower level of inflammatory markers, the treatment outcomes of subclinical TB were not significantly different from that of active disease.

scholarly journals Clinical profiles of subclinical disease among pulmonary tuberculosis patients: a prospective cohort study in South Korea

2020 ◽  
Author(s):  
Jinsoo Min ◽  
Chaeuk Chung ◽  
Sung Soo Jung ◽  
Hye Kyeong Park ◽  
Sung-Soon Lee ◽  
...  
Keyword(s):  
Cohort Study ◽  
South Korea ◽  
Treatment Outcomes ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Laboratory Data ◽  
Pulmonary Tb ◽  
Cell Counts ◽  
Subclinical Disease ◽  
Active Disease

Abstract Background: Subclinical tuberculosis (TB) is a potential target for public health intervention because its early identification may reduce TB transmission. We aimed to describe the clinical and laboratory findings of subclinical disease among pulmonary TB patients and compared treatment outcomes for subclinical and active diseases.Methods: In this prospective cohort study, we enrolled adult patients aged ≥19 years with pulmonary TB between 2016 and 2018. Subclinical TB was defined as radiographic or microbiologic test results consistent with TB without clinical symptoms. We implemented a two-stage symptom assessment using a predefined TB symptom checklist. Demographic, clinical, and laboratory data were compared between subclinical and active diseases using multivariate binary logistic regression analysis. We evaluated treatment outcomes in the drug-susceptible cohort. Results: Among 420 enrolled patients, 81 (19.3%) had subclinical TB. Multivariate analysis showed that age <65 years was the only variable significantly associated with subclinical disease. Subclinical disease had a significantly lower proportion of acid-fast bacilli smear and culture positivity and multiple lobe involvement compared to active disease. The white blood cell counts, platelet counts, and C-reactive protein levels were significantly higher among patients with active disease than among those with subclinical disease. Among 319 patients with treatment success in the drug-susceptible cohort, six (1.9%) recurrent cases were identified, and all were active disease. Patients with subclinical disease had a higher proportion of favourable outcomes; however, its odds ratio was insignificant.Conclusions: Nearly one-fifth of tuberculosis cases were subclinical in South Korea. Despite its milder clinical presentation and lower level of inflammatory markers, the treatment outcomes of subclinical TB were not significantly different from that of active disease.

scholarly journals Clinical profiles of subclinical disease among pulmonary tuberculosis patients: a prospective cohort study in South Korea

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jinsoo Min ◽  
Chaeuk Chung ◽  
Sung Soo Jung ◽  
Hye Kyeong Park ◽  
Sung-Soon Lee ◽  
...  
Keyword(s):  
Cohort Study ◽  
South Korea ◽  
Treatment Outcomes ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Multivariable Analysis ◽  
Pulmonary Tb ◽  
Cell Counts ◽  
Subclinical Disease ◽  
Active Disease

Abstract Background Subclinical tuberculosis (TB) is a potential target for public health intervention because its early identification may reduce TB transmission. We aimed to describe the clinical and laboratory findings of subclinical disease among pulmonary TB patients and compared treatment outcomes for subclinical and active diseases. Methods In this prospective cohort study, we enrolled adult patients aged ≥ 19 years with pulmonary TB between 2016 and 2018. Subclinical TB was defined as radiographic or microbiologic test results consistent with TB without clinical symptoms. We implemented a two-stage symptom assessment using a predefined TB symptom checklist. Demographic, clinical, and laboratory data were compared between subclinical and active diseases using multivariable binary logistic regression analysis. We evaluated treatment outcomes in the drug-susceptible cohort. Results Among 420 enrolled patients, 81 (19.3%) had subclinical TB. Multivariable analysis showed that age < 65 years was the only variable significantly associated with subclinical disease. Subclinical disease had a significantly lower proportion of acid-fast bacilli smear and culture positivity and multiple lobe involvement compared to active disease. The white blood cell counts, platelet counts, and C-reactive protein levels were significantly higher among patients with active disease than among those with subclinical disease. Among 319 patients with treatment success in the drug-susceptible cohort, six (1.9%) recurrent cases were identified, and all were active disease. Patients with subclinical disease had a higher proportion of favourable outcomes; however, its odds ratio was insignificant. Conclusions Nearly one-fifth of tuberculosis cases were subclinical in South Korea. Despite its milder clinical presentation and lower level of inflammatory markers, the treatment outcomes of subclinical TB were not significantly different from that of active disease.

scholarly journals Clinical profiles of subclinical disease among pulmonary tuberculosis patients: a prospective cohort study in South Korea

2020 ◽  
Author(s):  
Jinsoo Min ◽  
Chaeuk Chung ◽  
Sung Soo Jung ◽  
Hye Kyeong Park ◽  
Sung-Soon Lee ◽  
...  
Keyword(s):  
Cohort Study ◽  
South Korea ◽  
Treatment Outcomes ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Laboratory Data ◽  
Significant Variable ◽  
Pulmonary Tb ◽  
Subclinical Disease ◽  
Active Disease

Abstract Background: Subclinical tuberculosis (TB) is a potential target for public health intervention because its early identification may reduce TB transmission. Here, we have described clinical and laboratory findings of subclinical disease among pulmonary TB patients.Methods: In this prospective cohort study, we enrolled adult patients with pulmonary TB between 2016 and 2018. Subclinical TB was defined as the presence of radiographic or microbiologic test results consistent with TB without clinical symptoms. We implemented two-stage symptom assessment using a predefined TB symptom checklist. Demographic, clinical, and laboratory data were compared between subclinical and active disease using the multivariate binary logistic regression analysis. We evaluated treatment outcomes in the drug-susceptible cohort. Results: Among 420 enrolled patients, 81 (19.3%) had subclinical TB. Multivariate analysis showed that age <65 years was the only significant variable associated with subclinical disease. Subclinical disease had a significantly lower proportion of acid-fast bacilli smear and culture positivity and multiple lobe involvement compared to active disease. Among 319 patients with treatment success in the drug-susceptible cohort, six (1.9%) recurrent cases were identified, and all were active disease. Patients with subclinical disease had a higher proportion of favorable outcomes; however, its odds ratio was insignificant.Conclusions: Nearly one-fifth of tuberculosis cases were subclinical under the universal health coverage in South Korea. Despite its milder clinical presentation, the treatment outcomes of subclinical TB were not significantly different from that of active disease.

scholarly journals Nexus Between Tuberculosis and Diabetic Mellitus, A Prospective Cohort Study.

2020 ◽  
Author(s):  
Berhanu Elfu Feleke ◽  
Teferi Elfu Feleke ◽  
Melkamu Beyene Kassahun ◽  
Wondemu Gebrekirose Adane ◽  
Abere Genetu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Treatment Outcome ◽  
Glycemic Control ◽  
Clinical Response ◽  
Treatment Outcomes ◽  
Median Time ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Hba1c Level ◽  
Tb Treatment

Abstract Background: This work aimed to describe the clinical presentation of TB in patient with DM, to determine the effects of DM on TB treatment outcomes, to identify the effects of TB on glycemic control, and to describe the lipid profile of TB and DM patients. Methods: This prospective cohort study design was conducted. The data were collected from September 2018 to June 2020 using patient interviews, examining the patients, chart review, and collecting blood samples. Binary logistic regression was used to identify the determinants of TB treatment outcomes in the context of DM. Kaplan Meier survival curve was used to see the effects of DM on TB clinical response. Linear regression was used to identify the determinants of the HbA1c level during TB infection. Results: A total of 1092 study participants were included giving for the response rate at 93.81 %. Good TB treatment outcome was observed in 72.5 % of the patients [95 % CI: 69 % - 76 %]. The odds of good TB treatment outcomes were at 75 % lower in the presence of DM (AOR 0.25 [95 % CI: 0.08 – 0.73]). The median time of clinical response in TB and DM patients was 45 days interquartile range (IQR) of 8 days; the median time of clinical response in DM free TB patients was 9 days [IQR 2 days]. TB increased the HbA1c level of DM patients by 1.22 % (B 1.22 [95% CI: 1.11 – 1.34]). In six months period, 60 % of TB and DM patients had got 3 episodes of acute complications. Conclusion: DM significantly decreases the favorable treatment outcome of DOTS. TB predisposed DM patients for bad glycemic control and increased episodes of acute DM complications.

scholarly journals Treatment Outcomes of New Tuberculosis Patients Hospitalized in Kampala, Uganda: A Prospective Cohort Study

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e90614 ◽  
Author(s):  
Bruce J. Kirenga ◽  
Jonathan Levin ◽  
Irene Ayakaka ◽  
William Worodria ◽  
Nancy Reilly ◽  
...  
Keyword(s):  
Cohort Study ◽  
Treatment Outcomes ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Tuberculosis Patients

Habitual physical activity levels predict treatment outcomes in depressed adults: A prospective cohort study

2016 ◽  
Vol 88 ◽  
pp. 53-58 ◽  
Author(s):  
Mats Hallgren ◽  
Olivia Aya Nakitanda ◽  
Örjan Ekblom ◽  
Matthew P. Herring ◽  
Neville Owen ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cohort Study ◽  
Treatment Outcomes ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Habitual Physical Activity ◽  
Activity Levels ◽  
Physical Activity Levels
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