scholarly journals Bacterial microbiome of the chigger mite Leptotrombidium imphalum varies by life stage and infection with the scrub typhus pathogen Orientia tsutsugamushi

PLoS ONE ◽  
2018 ◽  
Vol 13 (12) ◽  
pp. e0208327 ◽  
Author(s):  
Loganathan Ponnusamy ◽  
Alexandra C. Willcox ◽  
R. Michael Roe ◽  
Silas A. Davidson ◽  
Piyada Linsuwanon ◽  
...  
Keyword(s):  
Scrub Typhus ◽  
Life Stage ◽  
Orientia Tsutsugamushi ◽  
Chigger Mite ◽  
Bacterial Microbiome

scholarly journals Monitoring Chigger Mites for Orientia tsutsugamushi in Field Small Mammals in Hwaseong-si, Gyeonggi-do, Korea, 2019-2020

2021 ◽  
Vol 59 (3) ◽  
pp. 319-324
Author(s):  
Young Yil Bahk ◽  
Seong Kyu Ahn ◽  
Jinyoung Lee ◽  
Hyung Wook Kwon ◽  
Sung Jong Hong ◽  
...  
Keyword(s):  
Small Mammals ◽  
Scrub Typhus ◽  
Rapid Diagnosis ◽  
The Other ◽  
Orientia Tsutsugamushi ◽  
Chigger Mite ◽  
Apodemus Agrarius ◽  
Tsutsugamushi Disease ◽  
Pcr Test

Incidence of tsutsugamushi disease (scrub typhus) caused by Orientia tsutsugamushi, is steadily increasing. It is a mite-borne disease transmitted by chigger mites. In this study, the chigger mites were collected from field small mammals in Hwaseong-si (city), Gyeonggi-do (province), Korea, 2019 and 2020. The field small mammals captured were 56 Apodemus agrarius (94.9%) and 3 Crocidura lasiura (5.1%). A total of 7,531 chigger mites were collected from the captured small mammals. Using PCR test, 153 chigger mite pools were examined and 17 pools were reported positive for O. tsutsugamushi. The O. tsutsugamushi were identified to 5 strains; Jecheon strain was most prevalent, followed by Boryong strain. The other strains were OI011, Taguchi, and Shimokoshi. Collectively, these results provide essential regional information on mite-borne tsutsugamushi disease in the Hwaseong-si, and further contribute to bring awareness and rapid diagnosis for the tsutsugamushi disease.

Scrub typhus (Orientia tsutsugamushi), A rapidly spreading epidemic in Chennai - A standalone lab experience

2016 ◽  
Vol 5 (09) ◽  
pp. 4896
Author(s):  
Sripriya C.S.* ◽  
Shanthi B. ◽  
Arockia Doss S. ◽  
Antonie Raj I. ◽  
Mohana Priya
Keyword(s):  
Scrub Typhus ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Febrile Illness ◽  
Orientia Tsutsugamushi ◽  
The Past ◽  
Igm Elisa ◽  
The Mean ◽  
Specific Symptoms ◽  
Symptoms And Signs

Scrub typhus (Orientia tsutsugamushi), is a strict intracellular bacterium which is reported to be a recent threat to parts of southern India. There is re-emergence of scrub typhus during the past few years in Chennai. Scrub typhus is an acute febrile illness which generally causes non-specific symptoms and signs. The clinical manifestations of this disease range from sub-clinical disease to organ failure to fatal disease. This study documents our laboratory experience in diagnosis of scrub typhus in patients with fever and suspected clinical symptoms of scrub typhus infection for a period of two years from April 2014 to April 2016 using immunochromatography and IgM ELISA methods. The study was conducted on 648 patients out of whom 188 patients were found to be positive for scrub typhus. Results also showed that pediatric (0 -12 years) and young adults (20 – 39 years) were more exposed to scrub typhus infection and female patients were more infected compared to male. The study also showed that the rate of infection was higher between September to February which also suggested that the infection rate is proportional to the climatic condition. Statistical analysis showed that the mean age of the patients in this study was 37.6, standard deviation was 18.97, CV % was 50.45. 

scholarly journals Scrub Typhus and Molecular Characterization of Orientia tsutsugamushi from Central Nepal

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 422
Author(s):  
Rajendra Gautam ◽  
Keshab Parajuli ◽  
Mythili Tadepalli ◽  
Stephen Graves ◽  
John Stenos ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Scrub Typhus ◽  
Febrile Illness ◽  
Acute Febrile Illness ◽  
Limited Information ◽  
Orientia Tsutsugamushi ◽  
Health Measures ◽  
Central Nepal ◽  
Vector Borne

Scrub typhus is a vector-borne, acute febrile illness caused by Orientia tsutsugamushi. Scrub typhus continues to be an important but neglected tropical disease in Nepal. Information on this pathogen in Nepal is limited to serological surveys with little information available on molecular methods to detect O. tsutsugamushi. Limited information exists on the genetic diversity of this pathogen. A total of 282 blood samples were obtained from patients with suspected scrub typhus from central Nepal and 84 (30%) were positive for O. tsutsugamushi by 16S rRNA qPCR. Positive samples were further subjected to 56 kDa and 47 kDa molecular typing and molecularly compared to other O. tsutsugamushi strains. Phylogenetic analysis revealed that Nepalese O. tsutsugamushi strains largely cluster together and cluster away from other O. tsutsugamushi strains from Asia and elsewhere. One exception was the sample of Nepal_1, with its partial 56 kDa sequence clustering more closely with non-Nepalese O. tsutsugamushi 56 kDa sequences, potentially indicating that homologous recombination may influence the genetic diversity of strains in this region. Knowledge on the circulating strains in Nepal is important to the development of diagnostic tests and vaccines to support public health measures to control scrub typhus in this country.

Detection of Immunoglobulin M and Immunoglobulin G Antibodies Against Orientia tsutsugamushi for Scrub Typhus Diagnosis and Serosurvey in Endemic Regions

2020 ◽  
Vol 57 (12) ◽  
pp. 1131-1134
Author(s):  
Mohan D. Gupte ◽  
Manish Gupte ◽  
Suchit Kamble ◽  
Arati Mane ◽  
Suvarna Sane ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Scrub Typhus ◽  
Immunoglobulin M ◽  
Orientia Tsutsugamushi

scholarly journals 1495Resistance of Fluoroquinolone in Orientia tsutsugamushi Due to gyrA Mutation in Scrub typhus

2014 ◽  
Vol 1 (suppl_1) ◽  
pp. S395-S395
Author(s):  
Soo Kyung CHO ◽  
Kyung Hwa Park ◽  
Su Mi Choi ◽  
Sook in Jung ◽  
Hee-Chang Jang ◽  
...  
Keyword(s):  
Scrub Typhus ◽  
Orientia Tsutsugamushi ◽  
Gyra Mutation

scholarly journals Ultrastructural visualization of Orientia tsutsugamushi in biopsied eschars and monocytes from scrub typhus patients in South Korea

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Hyun-Joo Ro ◽  
Hayoung Lee ◽  
Edmond Changkyun Park ◽  
Chang-Seop Lee ◽  
Seung Il Kim ◽  
...  
Keyword(s):  
South Korea ◽  
Scrub Typhus ◽  
Orientia Tsutsugamushi

scholarly journals Hemophagocytic lymphohistiocytosis with neurological manifestations in an infant with scrub typhus: a rare fatal occurrence

2018 ◽  
Vol 49 (1) ◽  
pp. 52-53
Author(s):  
Shipra Agrwal ◽  
Aashima Dabas ◽  
Mukta Mantan ◽  
Sangeeta Yadav
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Cells ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Scrub Typhus ◽  
Fatal Outcome ◽  
Central Nervous System Involvement ◽  
Neurological Manifestations ◽  
Orientia Tsutsugamushi ◽  
Mild Fever

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of unchecked activation of the immune system leading to phagocytosis of blood cells and proliferation of histiocytes in solid organs. HLH can be primary or secondary to infective, autoimmune and malignant conditions. Scrub typhus is an infective illness caused by Orientia tsutsugamushi, transmitted by mite. The illness ranges from mild fever with rash to severe multisystem illness. Scrub typhus has rarely been associated with secondary HLH. We report an infant with scrub typhus who progressed to develop HLH with central nervous system involvement with fatal outcome.

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