scholarly journals Batch adjustment by reference alignment (BARA): Improved prediction performance in biological test sets with batch effects

PLoS ONE ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. e0212669 ◽  
Author(s):  
Robin Gradin ◽  
Malin Lindstedt ◽  
Henrik Johansson
2020 ◽  
Vol 10 (7) ◽  
pp. 2555 ◽  
Author(s):  
Heedong Yang ◽  
Seungsoo Park ◽  
Kangbin Yim ◽  
Manhee Lee

About half of all exploit codes will become available within about two weeks of the release date of its vulnerability. However, 80% of the released vulnerabilities are never exploited. Since putting the same effort to eliminate all vulnerabilities can be somewhat wasteful, software companies usually use different methods to assess which vulnerability is more serious and needs an immediate patch. Recently, there have been some attempts to use machine learning techniques to predict a vulnerability’s exploitability. In doing so, a vulnerability’s related URL, called its reference, is commonly used as a machine learning algorithm’s feature. However, we found that some references contained proof-of-concept codes. In this paper, we analyzed all references in the National Vulnerability Database and found that 46,202 of them contained such codes. We compared prediction performances between feature matrix with and without reference information. Experimental results showed that test sets that used references containing proof-of-concept codes had better prediction performance than ones that used references without such codes. Even though the difference is not huge, it is clear that references having answer information contributed to the prediction performance, which is not desirable. Thus, it is better not to use reference information to predict vulnerability exploitation.


Diagnostica ◽  
2019 ◽  
Vol 65 (4) ◽  
pp. 193-204
Author(s):  
Johannes Baltasar Hessler ◽  
David Brieber ◽  
Johanna Egle ◽  
Georg Mandler ◽  
Thomas Jahn

Zusammenfassung. Der Auditive Wortlisten Lerntest (AWLT) ist Teil des Test-Sets Kognitive Funktionen Demenz (CFD; Cognitive Functions Dementia) im Rahmen des Wiener Testsystems (WTS). Der AWLT wurde entlang neurolinguistischer Kriterien entwickelt, um Interaktionen zwischen dem kognitiven Status der Testpersonen und den linguistischen Eigenschaften der Lernliste zu reduzieren. Anhand einer nach Alter, Bildung und Geschlecht parallelisierten Stichprobe von gesunden Probandinnen und Probanden ( N = 44) und Patientinnen und Patienten mit Alzheimer Demenz ( N = 44) wurde mit ANOVAs für Messwiederholungen überprüft, inwieweit dieses Konstruktionsziel erreicht wurde. Weiter wurde die Fähigkeit der Hauptvariablen des AWLT untersucht, zwischen diesen Gruppen zu unterscheiden. Es traten Interaktionen mit geringer Effektstärke zwischen linguistischen Eigenschaften und der Diagnose auf. Die Hauptvariablen trennten mit großen Effektstärken Patientinnen und Patienten von Gesunden. Der AWLT scheint bei vergleichbarer differenzieller Validität linguistisch fairer als ähnliche Instrumente zu sein.


2018 ◽  
Vol 21 (5) ◽  
pp. 381-387 ◽  
Author(s):  
Hossein Atabati ◽  
Kobra Zarei ◽  
Hamid Reza Zare-Mehrjardi

Aim and Objective: Human dihydroorotate dehydrogenase (DHODH) catalyzes the fourth stage of the biosynthesis of pyrimidines in cells. Hence it is important to identify suitable inhibitors of DHODH to prevent virus replication. In this study, a quantitative structure-activity relationship was performed to predict the activity of one group of newly synthesized halogenated pyrimidine derivatives as inhibitors of DHODH. Materials and Methods: Molecular structures of halogenated pyrimidine derivatives were drawn in the HyperChem and then molecular descriptors were calculated by DRAGON software. Finally, the most effective descriptors for 32 halogenated pyrimidine derivatives were selected using bee algorithm. Results: The selected descriptors using bee algorithm were applied for modeling. The mean relative error and correlation coefficient were obtained as 2.86% and 0.9627, respectively, while these amounts for the leave one out−cross validation method were calculated as 4.18% and 0.9297, respectively. The external validation was also conducted using two training and test sets. The correlation coefficients for the training and test sets were obtained as 0.9596 and 0.9185, respectively. Conclusion: The results of modeling of present work showed that bee algorithm has good performance for variable selection in QSAR studies and its results were better than the constructed model with the selected descriptors using the genetic algorithm method.


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