Influence of physical activity on serum vitamin D levels in people with multiple sclerosis

Abstract Background: In most cases, multiple sclerosis (MS) patients reduce physical activity with disease progression and many patients are found to be vitamin D deficient. The aim of this study was to evaluate the effect of daily physical activity in everyday life on 25-hydroxyvitamin-D3 (25(OH)D3) serum levels in mildly disabled patients with an Expanded Disability Status Scale (EDSS) ≤ 4.Methods: We analyzed serum 25(OH)D3 levels and recorded daily physical activity (activity duration, number of steps, distance, total calorie consumption) using an activity tracker for 14-days in 25 women and 15 men. Participants recorded their daily sun exposure time by diary during the study period.Results: We found a positive correlation between physical activity and 25(OH)D3 levels in both, Pearson correlation (r = 0.221) and multivariate regression analysis (B = 0.308, β = 0.236), which was stronger than correlation with sunlight exposure (B = -0.044, β = -0.081). EDSS and physical activity were weakly correlated (r = -0.228), but no correlation between EDSS and 25(OH)D3 levels was found (r = -0.077). There were no relevant differences in physical activity (p = 0.803) and 25(OH)D3 concentrations (p = 0.385) between the EDSS groups 0 – 1.5 and 2.0 – 4.0.Conclusion: Physical activity has an independent effect on vitamin D levels in MS patients with low-grade disability.

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No correlation was observed between vitamin D levels and disability of patients with multiple sclerosis between latitudes 18° and 30° South

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20160173 ◽

2017 ◽

Vol 75 (1) ◽

pp. 3-8 ◽

Cited By ~ 4

Author(s):

Yara Dadalti Fragoso ◽

Tarso Adoni ◽

Soniza Vieira Alves-Leon ◽

Samira L. Apostolos-Pereira ◽

Walter Oleschko Arruda ◽

...

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Large Population ◽

Serum Vitamin ◽

Serum Levels ◽

Serum Vitamin D ◽

Control Subjects ◽

Vitamin D Levels ◽

The Mean ◽

25 Oh Vitamin D

ABSTRACT Objective: Vitamin D has taken center stage in research and treatment of multiple sclerosis (MS). The objective of the present study was to assess the serum vitamin D levels of a large population of patients with MS and controls living in a restricted tropical area. Methods: Data from 535 patients with MS and 350 control subjects were obtained from 14 cities around the Tropic of Capricorn. Results: The mean serum 25-OH vitamin D level was 26.07 ± 10.27 ng/mL for the control subjects, and 28.03 ± 12.19 ng/mL for patients with MS. No correlation was observed between vitamin D levels and the disability of patients over the disease duration. Conclusion: At least for the region around the Tropic of Capricorn, serum levels of vitamin D typically are within the range of 20 to 30 ng/mL for controls and patients with MS.

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Association of Vitamin D Status with Chronic Disease Risk Factors and Cognitive Dysfunction in 50–70 Year Old Adults

Nutrients ◽

10.3390/nu11010141 ◽

2019 ◽

Vol 11 (1) ◽

pp. 141 ◽

Cited By ~ 2

Author(s):

Japneet Kaur ◽

Steven Ferguson ◽

Eduardo Freitas ◽

Ryan Miller ◽

Debra Bemben ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Vitamin D ◽

Chronic Diseases ◽

Disease Risk ◽

Serum Vitamin ◽

Old Adults ◽

Serum Vitamin D ◽

Chronic Disease Risk ◽

Vitamin D Levels

Vitamin D deficiency/insufficiency has been primarily associated with skeletal disorders, however, since vitamin D receptors are found on multiple types of cells, there is also a link to increased chronic disease risk and all-cause mortality. The aim of this study was to examine whether deficient/insufficient vitamin D levels are associated with risk factors of chronic diseases and cognitive dysfunction in 50 to 70 year old adults. Participants completed the health status, three-day dietary record and vitamin D food frequency, sun exposure, and international physical activity questionnaires. Cognitive function of the participants was assessed using the Automated Neuropsychological Assessment Metrics while body composition (percent body fat, android/gynoid ratio) was assessed using Dual Energy X-ray Absorptiometry. Applanation tonometry was used to obtain pressure wave forms at the radial artery to examine arterial stiffness and central pressures. A fasting blood draw was taken to measure vitamin D, blood lipid and glucose levels. Fifty percent of the participants (36/72) were vitamin D deficient/insufficient. Individuals in the low physical activity (PA) group had lower serum vitamin D concentration compared to those in the high PA group (p = 0.04). Moreover, serum vitamin D levels were negatively related to risk factors of chronic diseases; blood glucose (r = −0.38; p = 0.01), triglycerides (r = −0.27; p = 0.02), and android/gynoid ratio (r = −0.32; p = 0.01). Deficient/insufficient vitamin D levels are linked to the risk factors of chronic diseases in men and women aged 50 to 70 years.

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KLOTO rs1207588 allelic variant affects serum vitamin D levels in multiple sclerosis patients

Clinica Chimica Acta ◽

10.1016/j.cca.2019.03.1286 ◽

2019 ◽

Vol 493 ◽

pp. S614

Author(s):

L. Agnello ◽

C. Scazzone ◽

B. Lo Sasso ◽

G. Bivona ◽

G. Iacolino ◽

...

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Serum Vitamin ◽

Allelic Variant ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Multiple Sclerosis Patients

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Vitamin D levels and risk of multiple sclerosis in patients with clinically isolated syndromes

Multiple Sclerosis Journal ◽

10.1177/1352458513494959 ◽

2013 ◽

Vol 20 (2) ◽

pp. 147-155 ◽

Cited By ~ 58

Author(s):

Vittorio Martinelli ◽

Gloria Dalla Costa ◽

Bruno Colombo ◽

Dacia Dalla Libera ◽

Alessandro Rubinacci ◽

...

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Brain Magnetic Resonance Imaging ◽

Hydroxyvitamin D ◽

Serum Vitamin D ◽

Clinically Isolated Syndromes ◽

Vitamin D Levels ◽

Magnetic Resonance Imaging Mri

Background: Growing evidence suggests that vitamin D deficiency may be one of the most important environmental factors for the development of multiple sclerosis (MS). Objectives: The objectives of this paper are to evaluate serum 25-hydroxyvitamin D (25(OH)D) levels in patients with clinically isolated syndromes (CIS) and to examine whether they are related to MS risk. Methods: This is a retrospective study of 100 CIS patients hospitalized from 2000 to 2009 at San Raffaele Hospital, Milan, Italy. We evaluated baseline 25(OH)D level as well as clinical, brain magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) data. Results: A total of 52% of CIS patients had vitamin D deficiency (25(OH)D < 50 nmol/l). During follow-up (median: 7.17 years), 55 patients developed clinically definite MS (CDMS). Patients with very low (< 10th percentile) and low (< 25th percentile) 25(OH)D levels were particularly at risk of CDMS (HRs (95% CIs): 2.12 (0.91–4.96) and 1.61 (0.85–3.03), respectively), while no further reduction in the HRs of disease was observed at high levels of 25(OH)D. This association was even stronger after adjustment for additional risk factors for CDMS development (HRs (95% CIs) for 25(OH)D levels < 10th and 25th percentiles: 3.34 (1.32–8.45) and 2.04 (0.96–4.36), respectively). Conclusion: Low serum vitamin D is associated with increased MS risk in patients with CIS.

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