scholarly journals Plasma and urine metabolomic analyses in aortic valve stenosis reveal shared and biofluid-specific changes in metabolite levels

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0242019
Author(s):  
Cynthia Al Hageh ◽  
Ryan Rahy ◽  
Georges Khazen ◽  
Francois Brial ◽  
Rony S. Khnayzer ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
Elderly Population ◽  
The Elderly ◽  
Gas Chromatography Mass Spectrometry ◽  
Urine Metabolites ◽  
Aconitic Acid ◽  
Surgery In The Elderly ◽  
Diagnostic Applications ◽  
And Control

Aortic valve stenosis (AVS) is a prevalent condition among the elderly population that eventually requires aortic valve replacement. The lack of reliable biomarkers for AVS poses a challenge for its early diagnosis and the application of preventive measures. Untargeted gas chromatography mass spectrometry (GC-MS) metabolomics was applied in 46 AVS cases and 46 controls to identify plasma and urine metabolites underlying AVS risk. Multivariate data analyses were performed on pre-processed data (e.g. spectral peak alignment), in order to detect changes in metabolite levels in AVS patients and to evaluate their performance in group separation and sensitivity of AVS prediction, followed by regression analyses to test for their association with AVS. Through untargeted analysis of 190 urine and 130 plasma features that could be detected and quantified in the GC-MS spectra, we identified contrasting levels of 22 urine and 21 plasma features between AVS patients and control subjects. Following metabolite assignment, we observed significant changes in the concentration of known metabolites in urine (n = 14) and plasma (n = 15) that distinguish the metabolomic profiles of AVS patients from healthy controls. Associations with AVS were replicated in both plasma and urine for about half of these metabolites. Among these, 2-Oxovaleric acid, elaidic acid, myristic acid, palmitic acid, estrone, myo-inositol showed contrasting trends of regulation in the two biofluids. Only trans-Aconitic acid and 2,4-Di-tert-butylphenol showed consistent patterns of regulation in both plasma and urine. These results illustrate the power of metabolomics in identifying potential disease-associated biomarkers and provide a foundation for further studies towards early diagnostic applications in severe heart conditions that may prevent surgery in the elderly.

210 The Safety and Outcomes of Penile Implant Surgery in the Elderly Population

2018 ◽  
Vol 15 (2) ◽  
pp. S69-S70
Author(s):  
P. Teloken ◽  
E. Miranda ◽  
C. Kagacan ◽  
S. Deveci ◽  
J. Mulhall
Keyword(s):  
Elderly Population ◽  
The Elderly ◽  
Implant Surgery ◽  
Penile Implant ◽  
Surgery In The Elderly

scholarly journals Prevalence, awareness, treatment and control of hypertension in the elderly population of Singapore

2010 ◽  
Vol 33 (12) ◽  
pp. 1223-1231 ◽  
Author(s):  
Rahul Malhotra ◽  
Angelique Chan ◽  
Chetna Malhotra ◽  
Truls Østbye
Keyword(s):  
Elderly Population ◽  
The Elderly ◽  
And Control

Serotonin Antagonists Prevent Cytokine and Mechanical Activation of Aortic Valve Interstitial Cells

2010 ◽  
Author(s):  
Joshua D. Hutcheson ◽  
W. David Merryman
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Disease ◽  
Elderly Population ◽  
Population Studies ◽  
The Elderly ◽  
Severe Form ◽  
Similar Increase ◽  
Valve Interstitial Cells ◽  
Replacement Surgery ◽  
Valve Pathology

Degenerative aortic valve disease (DAVD) is the most common heart valve pathology and is especially prevalent in the elderly population. Studies have shown that stenosis, the most severe form of DAVD, increases in prevalence from 0.7% in people between 18 and 44 years of age to over 13% of people over 75 years of age. Furthermore, early symptoms of DAVD have been detected in 29% of patients over 65 years of age. These symptoms are associated with a 50% increase in cardiovascular related morbidity and a similar increase in the risk of myocardial infarction [1]. Currently, aortic valve (AV) replacement surgery is the only method available to correct DAVD, and while these procedures have become less invasive, replacement valves are still rather expensive and do not function as well as native valves. Therefore, the development of a therapeutic that could prevent DAVD would greatly benefit many patients.

scholarly journals Current State of Symptomatic Aortic Valve Stenosis in the Elderly Patient

2011 ◽  
Vol 75 (10) ◽  
pp. 2324-2325 ◽  
Author(s):  
Anna Sonia Petronio ◽  
Cristina Giannini ◽  
Leonardo Misuraca
Keyword(s):  
Elderly Patient ◽  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
The Elderly ◽  
Current State

Treatment with HMG-CoA reductase inhibitors (statins) attenuates the progression of aortic valve stenosis in the elderly

2006 ◽  
Vol 6 (2) ◽  
pp. 124-128 ◽  
Author(s):  
Masanori Kuwabara ◽  
Hiroaki Kitaoka ◽  
Makoto Okawa ◽  
Takashi Furuno ◽  
Masanori Nishinaga ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
The Elderly ◽  
Hmg Coa Reductase ◽  
Reductase Inhibitors ◽  
Hmg Coa Reductase Inhibitors ◽  
Coa Reductase

P4557Factors associated with treatment and control of hypertension in a healthy elderly population free of cardiovascular disease: a cross-sectional study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
E Chowdhury ◽  
M R Nelson ◽  
M E Ernst ◽  
K L Margolis ◽  
L J Beilin ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Elderly Population ◽  
Educational Status ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Uncontrolled Hypertension ◽  
Ageing Population ◽  
Cross Sectional ◽  
Healthy Elderly ◽  
And Control

Abstract Introduction Despite readily available treatments, control of high blood pressure (BP) in the ageing population remains suboptimal. Gaps in understanding the management of high BP amongst the elderly exist, as most studies have been in predominantly middle-aged populations. Purpose We explored pharmacological BP lowering treatment and control among elderly hypertensive participants free from overt cardiovascular disease (CVD), and identified factors related to both “untreated” and “treated but uncontrolled” high BP. Methods We analyzed baseline data from 19,114 individuals aged ≥65 years enrolled from Australia and the US in the ASPirin in Reducing Events in the Elderly (ASPREE) study. Hypertension was defined as an average systolic/diastolic BP ≥140/90 mmHg and/or use of any BP-lowering medication. `Controlled hypertensives” were those receiving BP-lowering medication and with BP <140/90 mmHg. Descriptive analyses were used to summarize hypertension control rates; logistic regression was used to investigate relationships with treatment and BP control. Results Overall, 74% (14,213/19,114) of participants were hypertensive, and of these 29% (4,151/14,213) were untreated. Among those treated, 47% (4,732/10,062) had BP <140/90 mmHg. Participants who were untreated were more likely to be men, have higher educational status, and be in good physical health, and less likely to have significant comorbidities. The factors related to “treated but uncontrolled” hypertension included older age, being men, Black race (versus White), using BP lowering monotherapy and residing in Australia (versus US) (Figure 1). Conclusion(s) There were high levels of “untreated” and “treated but uncontrolled” BP, in an otherwise healthy elderly population, suggesting that opportunities for better BP control exist through targeting intervention to high-risk individuals. Acknowledgement/Funding National Institute on Aging and the National Cancer Institute at NIH; NHMRC Australia, Monash University, Victorian Cancer Agency (Australia)

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