scholarly journals Resting-state functional connectivity and quantitation of glutamate and GABA of the PCC/precuneus by magnetic resonance spectroscopy at 7T in healthy individuals

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0244491
Author(s):  
Ofer M. Gonen ◽  
Bradford A. Moffat ◽  
Patrick Kwan ◽  
Terence J. O’Brien ◽  
Patricia M. Desmond ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Functional Connectivity ◽  
Magnetic Resonance Spectroscopy ◽  
Large Scale ◽  
Resonance Spectroscopy ◽  
Resting State Functional Connectivity ◽  
Disease States ◽  
Large Scale Network ◽  
Age Related ◽  
Scale Network

The default mode network (DMN) is the main large-scale network of the resting brain and the PCC/precuneus is a major hub of this network. Glutamate and GABA (γ-amino butyric acid) are the main excitatory and inhibitory neurotransmitters in the CNS, respectively. We studied glutamate and GABA concentrations in the PCC/precuneus via magnetic resonance spectroscopy (MRS) at 7T in relation to age and correlated them with functional connectivity between this region and other DMN nodes in ten healthy right-handed volunteers ranging in age between 23–68 years. Mean functional connectivity of the PCC/precuneus to the other DMN nodes and the glutamate/GABA ratio significantly correlated with age (r = 0.802, p = 0.005 and r = 0.793, p = 0.006, respectively) but not with each other. Glutamate and GABA alone did not significantly correlate with age nor with functional connectivity within the DMN. The glutamate/GABA ratio and functional connectivity of the PCC/precuneus are, therefore, independent age-related biomarkers of the DMN and may be combined in a multimodal pipeline to study DMN alterations in various disease states.

scholarly journals Edited magnetic resonance spectroscopy detects an age-related decline in brain GABA levels

NeuroImage ◽  
2013 ◽  
Vol 78 ◽  
pp. 75-82 ◽  
Author(s):  
Fei Gao ◽  
Richard A.E. Edden ◽  
Muwei Li ◽  
Nicolaas A.J. Puts ◽  
Guangbin Wang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Age Related ◽  
Brain Gaba

Muscle metabolism in older subjects using 31P magnetic resonance spectroscopy

1991 ◽  
Vol 69 (5) ◽  
pp. 576-580 ◽  
Author(s):  
Kevin K. McCully ◽  
Mary Ann Forciea ◽  
Laurita M. Hack ◽  
Eileen Donlon ◽  
Roger W. Wheatley ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Time Constant ◽  
Plantar Flexion ◽  
Muscle Metabolism ◽  
The Elderly ◽  
Elderly Subjects ◽  
Resonance Spectroscopy ◽  
Medical Problems ◽  
Age Related

We used phosphorus magnetic resonance spectroscopy to study the calf muscles of elderly normal (mean ± SD) (80.0 ± 5.12 years), elderly impaired (80.7 ± 0.58 years), old normal (66.8 ± 1.92 years), and young normal people (24.6 ± 4.72 years). Relative levels of inorganic phosphate (Pi), phosphocreatine (PCr), and adenosine triphosphate were measured with a 1.9-tesla, 30-cm bore magnet at rest and following plantra flexon exercise. No differences were found at rest or during recovery from exercise in the elderly normal subjects with respect to gender or the presence of stable medical problems treated with medication. At rest there was an age-related decrease in the ratio of PCr/Pi. After exercise, the time constant of PCr recovery increased with age. A mild 7-week exercise regimen consisting of plantar flexion had no effect on time constant of PCr recovery in the elderly subjects. Four elderly impaired subjects had lower PCr/Pi ratios at rest and slower time constant of PCr recovery after exercise than normal elderly subjects. We conclude that gender and the presence of stable medical problems had no effect on muscle metabolism in the elderly and that the elderly recovered slower than young controls. This slower recovery was not corrected with a mild exercise program.Key words: human muscle, aging, exercise, nuclear magnetic resonance, gastrocnemius.

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