scholarly journals Personality dimensions of patients can change during the course of parkinson’s disease

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0245142
Author(s):  
Mathilde Boussac ◽  
Christophe Arbus ◽  
Julia Dupouy ◽  
Estelle Harroch ◽  
Vanessa Rousseau ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
De Novo ◽  
Motor Fluctuations ◽  
Novelty Seeking ◽  
Temperament And Character Inventory ◽  
Personality Dimensions ◽  
Normative Population ◽  
Character Inventory ◽  
Deep Brain

Background Studies assessing personality dimensions by the “Temperament and Character Inventory” (TCI) have previously found an association between Parkinson’s disease (PD) and lower Novelty Seeking and higher Harm Avoidance scores. Here, we aimed to describe personality dimensions of PD patients with motor fluctuations and compare them to a normative population and other PD populations. Methods All PD patients awaiting Deep Brain Stimulation (DBS) answered the TCI before neurosurgery. Their results were compared to those of historical cohorts (a French normative population, a de novo PD population, and a PD population with motor fluctuations). Results Most personality dimensions of our 333 included PD patients with motor fluctuations who are candidates for DBS were different from those of the normative population and some were also different from those of the De Novo PD population, whereas they were similar to those of another population of PD patients with motor fluctuations. Conclusions During the course of PD, personality dimensions can change in parallel with the development of motor fluctuations, either due to the evolution of the disease and/or dopaminergic treatments.

Distributions by Age and Sex of the Dimensions of Temperament and Character Inventory in a Cross-Cultural Perspective among Sweden, Germany, and the USA

2001 ◽  
Vol 89 (3) ◽  
pp. 747-758 ◽  
Author(s):  
Sven Brändström ◽  
Jörg Richter ◽  
Tom Przybeck
Keyword(s):  
Novelty Seeking ◽  
Cultural Perspective ◽  
Temperament And Character Inventory ◽  
Personality Dimensions ◽  
Biosocial Theory ◽  
Age Cohort ◽  
Character Inventory ◽  
The Usa ◽  
Self Transcendence ◽  
Age And Sex

Distribution by age and sex of the dimensions of the Temperament and Character Inventory were assessed cross-culturally for samples in Sweden, Germany, and the USA. The Temperament and Character Inventory is a 240-item (Sweden, 238-item), self-administered, true-false format, paper-and-pencil test developed by Cloninger and his coworkers based on his unified biosocial theory of personality. The inventory measures the Temperament dimensions Novelty Seeking, Harm Avoidance, Reward Dependence, and Persistence as well as the Character dimensions, Self-directedness, Cooperativeness, and Self-transcendence. The samples consisted of 300 German subjects, 300 Swedish subjects, and 300 U.S. subjects matched by age cohort and sex. Stability of the personality dimensions was evaluated across samples as were their age and sex distributions. We found significant effects of age, sex, and culture in univeriate and multivariate comparisons on the personality dimensions. However, several significant differences in the personality dimensions for both European samples appear to be similar compared with those of the U.S. sample. We have to conclude that sex- and age-specific norms for the dimensions of the Temperament and Character Inventory are necessary given the established significant differences.

Personality Related to Quality-of-Life Improvement After Deep Brain Stimulation in Parkinson’s Disease (PSYCHO-STIM II)

2021 ◽  
pp. 1-13
Author(s):  
Mathilde Boussac ◽  
Christophe Arbus ◽  
Helene Klinger ◽  
Alexandre Eusebio ◽  
Elodie Hainque ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Linear Regression Models ◽  
Personality Dimensions ◽  
One Year ◽  
Deep Brain

Background: Deep brain stimulation of the sub-thalamic nucleus (DBS-STN) reduces symptoms in Parkinson’s disease (PD) patients with motor fluctuations. However, some patients may not feel ameliorated afterwards, despite an objective motor improvement. It is thus important to find new predictors of patients’ quality of life (QoL) amelioration after DBS-STN. We hypothesized that personality dimensions might affect QoL after DBS-STN. Objective: To evaluate associations between personality dimensions and QoL improvement one year after DBS-STN. Methods: DBS-STN-PD patients (n = 303) having answered the “Temperament and Character Inventory” (TCI) before surgery and the PDQ-39 before and one year after surgery were included, from the cohort study PREDI-STIM. Linear regression models were used to evaluate associations between TCI dimensions and change in PDQ-39 scores after DBS-STN. Results: Novelty Seeking and Cooperativeness scores before surgery were positively associated with PDQ-39 scores improvement after DBS-STN (FDR-adjusted p <  0.01). Moreover, paradoxically unimproved patients with deterioration of their PDQ-39 scores after DBS-STN despite improvement of their MDS-UPDRS-IV scores had lower Cooperativeness scores, while paradoxically improved patients with amelioration of their PDQ-39 scores despite deterioration of their MDS-UPDRS-IV scores had higher Reward Dependence scores. Conclusion: Some presurgical personality dimensions were significantly associated with QoL amelioration and discrepancy between motor state and QoL changes after DBS-STN in PD. Educational programs before DBS-STN should take in account patient personality dimensions to better deal with their expectations.

Continuous infusion of apomorphine in a series of thirty patients with parkinson's disease

2019 ◽  
pp. 43-47 ◽  
Author(s):  
Rezzak Yılmaz ◽  
Çağlar Sarılar ◽  
Cenk Akbostancı
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Adverse Events ◽  
Medical Records ◽  
Motor Fluctuations ◽  
Motor Complications ◽  
Subcutaneous Nodules ◽  
Disease Characteristics ◽  
Deep Brain

Apomorphine is a dopamine agonist primarily used for the treatment of motor fluctuations and severe dyskinesias in late – stage Parkinson’s Disease. We retrospectively studied medical records of 30 patients who were on continuous apomorphine infusion treatment. They were evaluated for their disease characteristics, satisfaction for the therapy and adverse events. Results showed that 17 patients were satisfied with the therapy. The main reason of cessation of therapy (15 patients) was subthalamic nucleus deep brain stimulation. Arrythmia and subcutaneous nodules were relatively rare (3 patients). Results were compared with similar studies. Apomorphine therapy appears as a safe option for patients with motor complications and cognitive or neuropsychiatric problems.

Effect of deep brain stimulation of the subthalamic nucleus on non-motor fluctuations in Parkinson's disease: Two-year' follow-up

2013 ◽  
Vol 19 (5) ◽  
pp. 543-547 ◽  
Author(s):  
Sara Ortega-Cubero ◽  
Pedro Clavero ◽  
Cecilia Irurzun ◽  
Rafael Gonzalez-Redondo ◽  
Jorge Guridi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Motor Fluctuations ◽  
Deep Brain ◽  
Stimulation Of

Temperament and Character Inventory (TCI) in adolescents with anorexia nervosa

2004 ◽  
Vol 16 (3) ◽  
pp. 169-174 ◽  
Author(s):  
Filip Rybakowski ◽  
Agnieszka Slopien ◽  
Marzena Zakrzewska ◽  
Elzbieta Hornowska ◽  
Andrzej Rajewski
Keyword(s):  
Anorexia Nervosa ◽  
Adult Patients ◽  
Novelty Seeking ◽  
Temperament And Character Inventory ◽  
Personality Dimensions ◽  
Significance Level ◽  
Adolescent Patients ◽  
Character Inventory ◽  
Self Transcendence ◽  
And Control

Background:Female patients with anorexia nervosa differ significantly from the control women in various dimensions of personality.Objective:To investigate the personality dimensions measured with the Temperament and Character Inventory (TCI) in adolescent patients with restrictive-type and bulimic/purging-type anorexia nervosa (ANR and ANB, respectively), and contrast them with the results of control females.Methods:Sixty-one patients with anorexia nervosa (36 ANR and 25 ANB) and 60 controls were tested with the TCI. A concomitant assessment of depression, body mass index and age was made to evaluate the possible correlation with personality dimensions.Results:Adolescent ANR patients scored higher in persistence, harm avoidance and cooperativeness, and lower in novelty seeking and self-transcendence than control women. ANB patients scored in the middle between ANR and control females, but differences did not reach the significance level with either group, except for the self-transcendence dimension where they scored significantly higher than those with ANR.Conclusions:The deviations in temperamental profile of adolescent ANR are similar to those reported in adult patients. The ANB adolescent patients with anorexia nervosa show less prominent deviations from the personality of control women. With regard to the character dimension of cooperativeness, adolescents with ANR scored higher than controls, in contrast to the observations in adult patients. This may reflect the effect of illness on the development of character.

scholarly journals Možnosti zdravljenja napredovale Parkinsonove bolezni

2016 ◽  
Vol 85 (7-8) ◽  
Author(s):  
Dušan Flisar ◽  
Nina Zupančič Križnar ◽  
Maja Trošt ◽  
Zvezdan Pirtošek
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Fluctuations ◽  
Dopamine Neurons ◽  
Advanced Stage ◽  
Optimal Method ◽  
Subcutaneous Infusion ◽  
The Individual ◽  
Deep Brain ◽  
Stimulation Of

Advanced stage of Parkinson's disease is associated with motor complications: motor fluctuations and dyskinesias. The disease can no longer be satisfactorily treated with oral therapy that is based on treatment with levodopa. Dying of dopamine neurons, a short half-life of levodopa and pulsatile stimulation of dopamine receptors are the main reasons for these complications. Currently, there are three options available to treat the advanced stage of Parkinson's disease: subcutaneous infusion of apomorphine, intrajejunal infusion of levodopa and deep brain stimulation. It is necessary to choose the optimal method of treatment that is most suitable for the individual patient.

Apomorphine in the Treatment of Parkinson’s Disease

2009 ◽  
Vol 4 (1) ◽  
pp. 28 ◽  
Author(s):  
Regina Katzenschlager ◽  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Treatment Options ◽  
Motor Fluctuations ◽  
Infusion Therapy ◽  
Motor Complications ◽  
Pump System ◽  
Portable Pump ◽  
Deep Brain

The majority of patients with Parkinson’s disease (PD) develop motor fluctuations and dyskinesias as their condition progresses. In patients where adjustments of oral (or transdermal) treatment options can no longer adequately control these motor complications, further options include deep-brain stimulation for a minority of selected patients, intrajejunal levodopa (L-dopa) application via a pump or apomorphine infusion therapy. The dopamine agonist apomorphine provides relief from off periods when administered as a subcutaneous injection. When applied continuously via a portable pump system, oral medication can often be reduced considerably and dyskinesias improve in many patients.

Sign in / Sign up

Export Citation Format

Share Document