scholarly journals Neutrophil-to-lymphocyte ratio, platelets-to-lymphocyte ratio, and eosinophils correlation with high-resolution computer tomography severity score in COVID-19 patients

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252599
Author(s):  
Milena Adina Man ◽  
Ruxandra-Mioara Rajnoveanu ◽  
Nicoleta Stefania Motoc ◽  
Cosmina Ioana Bondor ◽  
Ana Florica Chis ◽  
...  
Keyword(s):  
Ct Scan ◽  
Inflammatory Markers ◽  
Chest Ct ◽  
Neutrophil To Lymphocyte Ratio ◽  
Circulating Biomarkers ◽  
Lymphocyte Ratio ◽  
A Value ◽  
Thorax Ct ◽  
Chest Ct Scan ◽  
Future Management

Inflammation has an important role in the progression of various viral pneumonia, including COVID-19. Circulating biomarkers that can evaluate inflammation and immune status are potentially useful in diagnosing and prognosis of COVID-19 patients. Even more so when they are a part of the routine evaluation, chest CT could have even higher diagnostic accuracy than RT-PCT alone in a suggestive clinical context. This study aims to evaluate the correlation between inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR), platelets-to-lymphocytes ratio (PLR), and eosinophils with the severity of CT lesions in patients with COVID-19. The second objective was to seek a statically significant cut-off value for NLR and PLR that could suggest COVID-19. Correlation of both NLR and PLR with already established inflammatory markers such as CRP, ESR, and those specific for COVID-19 (ferritin, D-dimers, and eosinophils) were also evaluated. One hundred forty-nine patients with confirmed COVID-19 disease and 149 age-matched control were evaluated through blood tests, and COVID-19 patients had thorax CT performed. Both NLR and PLR correlated positive chest CT scan severity. Both NLR and PLR correlated positive chest CT scan severity. When NLR value is below 5.04, CT score is lower than 3 with a probability of 94%, while when NLR is higher than 5.04, the probability of severe CT changes is only 50%. For eosinophils, a value of 0.35% corresponds to chest CT severity of 2 (Se = 0.88, Sp = 0.43, AUC = 0.661, 95% CI (0.544; 0.779), p = 0.021. NLR and PLR had significantly higher values in COVID-19 patients. In our study a NLR = 2.90 and PLR = 186 have a good specificity (0.89, p = 0.001, respectively 0.92, p<0.001). Higher levels in NLR, PLR should prompt the clinician to prescribe a thorax CT as it could reveal important lesions that could influence the patient’s future management.

scholarly journals Neutrophil-to-lymphocyte ratio (NLR) and Platelets-to-lymphocyte (PLR) Ratio in Patients with Exacerbation of Bronchiectasis

2019 ◽  
Vol 70 (11) ◽  
pp. 3889-3892
Author(s):  
Nicoleta Stefania Motoc ◽  
Paula Martinovici ◽  
Beatrice Mahler Boca ◽  
Ioan Sorin Tudorache ◽  
Tudor Harsovescu ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Blood Cells ◽  
Inflammatory Markers ◽  
Blood Test ◽  
White Blood Cells ◽  
Chest Ct ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Gold Stage

Neutrophil-to-lymphocyte ratio (NLR) and platelets-to-lymphocyte ratio(PLR) are novel inflammatory markers used in evaluation of systemic inflammation. The aim of this study was to evaluate the utility of NLR and PLR as inflammatory markers in patients with exacerbation of bronchiectasis. 100 patients with age between 23 and 88 years old with chest CT documentated bronchiectasis were included. Blood test were collected at admission in the hospital. There was a good correlation between classical markers such as CRP, ESR, white blood cells and NLR. PLR, however correlated only with ESR from the inflammatory markers and with the values og hemoglobin and hematocrit. We did not see higher values in patients with COPD and bronchiectasis when compared with patients with bronchiectasis alone, howevere patients with COPD GOLD stage 2 and bronchiectasis had higher values of NLR and PLR when compared with other stages. NLR, more than PLR can be safley used in evaluating inflammation in patients with exacerbation of bronchiectasis.

scholarly journals Neutrophil-to-lymphocyte ratio (NLR) and Platelets-to-lymphocyte (PLR) Ratio in Patients with Exacerbation of Bronchiectasis

2019 ◽  
Vol 70 (11) ◽  
pp. 3889-3892 ◽  
Author(s):  
Nicoleta Stefania Motoc ◽  
Paula Martinovici ◽  
Beatrice Mahler Boca ◽  
Ioan Sorin Tudorache ◽  
Tudor Harsovescu ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Blood Cells ◽  
Inflammatory Markers ◽  
Blood Test ◽  
White Blood Cells ◽  
Chest Ct ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Gold Stage

Neutrophil-to-lymphocyte ratio (NLR) and platelets-to-lymphocyte ratio(PLR) are novel inflammatory markers used in evaluation of systemic inflammation. The aim of this study was to evaluate the utility of NLR and PLR as inflammatory markers in patients with exacerbation of bronchiectasis. 100 patients with age between 23 and 88 years old with chest CT documentated bronchiectasis were included. Blood test were collected at admission in the hospital. There was a good correlation between classical markers such as CRP, ESR, white blood cells and NLR. PLR, however correlated only with ESR from the inflammatory markers and with the values og hemoglobin and hematocrit. We did not see higher values in patients with COPD and bronchiectasis when compared with patients with bronchiectasis alone, howevere patients with COPD GOLD stage 2 and bronchiectasis had higher values of NLR and PLR when compared with other stages. NLR, more than PLR can be safley used in evaluating inflammation in patients with exacerbation of bronchiectasis.

Cancer surgery during the COVID‐19 pandemic: The experience of a comprehensive cancer center performing preoperative screening by RT‐PCR and chest CT scan

2021 ◽  
Vol 123 (4) ◽  
pp. 815-822
Author(s):  
Joanne Guerlain ◽  
Fabienne Haroun ◽  
Alexandra Voicu ◽  
Charles Honoré ◽  
Franck Griscelli ◽  
...  
Keyword(s):  
Ct Scan ◽  
Chest Ct ◽  
Cancer Surgery ◽  
Comprehensive Cancer Center ◽  
Cancer Center ◽  
Preoperative Screening ◽  
Rt Pcr ◽  
Chest Ct Scan

scholarly journals A meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in COVID-19 diagnosis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Fatemeh Khatami ◽  
Mohammad Saatchi ◽  
Seyed Saeed Tamehri Zadeh ◽  
Zahra Sadat Aghamir ◽  
Alireza Namazi Shabestari ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Reverse Transcriptase ◽  
Ct Scan ◽  
Predictive Value ◽  
Meta Analysis ◽  
Chest Ct ◽  
Rt Pcr ◽  
Chain Reaction ◽  
Polymerase Chain ◽  
Chest Ct Scan

AbstractNowadays there is an ongoing acute respiratory outbreak caused by the novel highly contagious coronavirus (COVID-19). The diagnostic protocol is based on quantitative reverse-transcription polymerase chain reaction (RT-PCR) and chests CT scan, with uncertain accuracy. This meta-analysis study determines the diagnostic value of an initial chest CT scan in patients with COVID-19 infection in comparison with RT-PCR. Three main databases; PubMed (MEDLINE), Scopus, and EMBASE were systematically searched for all published literature from January 1st, 2019, to the 21st May 2020 with the keywords "COVID19 virus", "2019 novel coronavirus", "Wuhan coronavirus", "2019-nCoV", "X-Ray Computed Tomography", "Polymerase Chain Reaction", "Reverse Transcriptase PCR", and "PCR Reverse Transcriptase". All relevant case-series, cross-sectional, and cohort studies were selected. Data extraction and analysis were performed using STATA v.14.0SE (College Station, TX, USA) and RevMan 5. Among 1022 articles, 60 studies were eligible for totalizing 5744 patients. The overall sensitivity, specificity, positive predictive value, and negative predictive value of chest CT scan compared to RT-PCR were 87% (95% CI 85–90%), 46% (95% CI 29–63%), 69% (95% CI 56–72%), and 89% (95% CI 82–96%), respectively. It is important to rely on the repeated RT-PCR three times to give 99% accuracy, especially in negative samples. Regarding the overall diagnostic sensitivity of 87% for chest CT, the RT-PCR testing is essential and should be repeated to escape misdiagnosis.

scholarly journals The role of CT imaging for management of COVID-19 in epidemic area: early experience from a University Hospital

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Vikram rao Bollineni ◽  
Koenraad Hans Nieboer ◽  
Seema Döring ◽  
Nico Buls ◽  
Johan de Mey
Keyword(s):  
Ct Scan ◽  
Predictive Value ◽  
Ct Imaging ◽  
Chest Ct ◽  
University Hospital ◽  
Rt Pcr ◽  
Ct Findings ◽  
Epidemic Area ◽  
Chest Ct Scan ◽  
Pcr Test

Abstract Background To evaluate the clinical value of the chest CT scan compared to the reference standard real-time polymerase chain reaction (RT-PCR) in COVID-19 patients. Methods From March 29th to April 15th of 2020, a total of 240 patients with respiratory distress underwent both a low-dose chest CT scan and RT-PCR tests. The performance of chest CT in diagnosing COVID-19 was assessed with reference to the RT-PCR result. Two board-certified radiologists (mean 24 years of experience chest CT), blinded for the RT-PCR result, reviewed all scans and decided positive or negative chest CT findings by consensus. Results Out of 240 patients, 60% (144/240) had positive RT-PCR results and 89% (213/240) had a positive chest CT scans. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of chest CT in suggesting COVID-19 were 100% (95% CI: 97–100%, 144/240), 28% (95% CI: 19–38%, 27/240), 68% (95% CI: 65–70%) and 100%, respectively. The diagnostic accuracy of the chest CT suggesting COVID-19 was 71% (95% CI: 65–77%). Thirty-three patients with positive chest CT scan and negative RT-PCR test at baseline underwent repeat RT-PCR assay. In this subgroup, 21.2% (7/33) cases became RT-PCR positive. Conclusion Chest CT imaging has high sensitivity and high NPV for diagnosing COVID-19 and can be considered as an alternative primary screening tool for COVID-19 in epidemic areas. In addition, a negative RT-PCR test, but positive CT findings can still be suggestive of COVID-19 infection.

A 71-Year-Old Man With Fever, Productive Cough, and Tree-in-Bud Pattern on Chest CT Scan

CHEST Journal ◽  
2013 ◽  
Vol 144 (2) ◽  
pp. 700-703 ◽  
Author(s):  
Sarah Bastawrous ◽  
Jan V. Hirschmann
Keyword(s):  
Ct Scan ◽  
Chest Ct ◽  
Productive Cough ◽  
Chest Ct Scan

PULMONARY BIRT-HOGG-DUBE SYNDROME: A GOOD REASON TO ROUTINELY PERFORM A LOW DOSE CHEST CT SCAN IN PATIENTS WITH PRIMARY SPONTANEOUS PNEUMOTHORAX?

CHEST Journal ◽  
2018 ◽  
Vol 154 (4) ◽  
pp. 576A
Author(s):  
JINCEY SRIRAM ◽  
IRMA VAN DE BEEK ◽  
PAUL JOHANNESMA ◽  
MICHIEL VAN WERKUM ◽  
TIJMEN VAN DER WEL ◽  
...  
Keyword(s):  
Ct Scan ◽  
Spontaneous Pneumothorax ◽  
Low Dose ◽  
Good Reason ◽  
Chest Ct ◽  
Primary Spontaneous Pneumothorax ◽  
Chest Ct Scan

scholarly journals Chest CT scan as an initial diagnostic method for tuberculosis infection detected by mass screening

2020 ◽  
Author(s):  
Dong-Hyun Joo ◽  
Hyun Woo Lee ◽  
Seo-Young Yoon ◽  
Tae Yun Park ◽  
Eun Young Heo ◽  
...  
Keyword(s):  
Ct Scan ◽  
Mass Screening ◽  
Diagnostic Method ◽  
Chest Ct ◽  
Tuberculosis Infection ◽  
Chest Ct Scan

scholarly journals Post-COVID-19 pulmonary fibrosis and its predictive factors: a prospective study

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Mehrdad Nabahati ◽  
Soheil Ebrahimpour ◽  
Reza Khaleghnejad Tabari ◽  
Rahele Mehraeen
Keyword(s):  
Pulmonary Fibrosis ◽  
Ct Scan ◽  
Predictive Factors ◽  
Lung Fibrosis ◽  
Chest Ct ◽  
Clinical Severity ◽  
Secondary Outcome ◽  
Increased Risk ◽  
Chest Ct Scan

Abstract Background We aimed to prospectively assess the lung fibrotic-like changes, as well as to explore their predictive factors, in the patients who survived Coronavirus Disease 2019 (COVID-19) infection. In this prospective cross-sectional study, we recruited patients who had been treated for moderate or severe COVID-19 pneumonia as inpatients and discharged from Rohani hospital in Babol, northern Iran, during March 2020. The clinical severity of COVID-19 pneumonia was classified as per the definition by World Health Organization. We also calculated the CT severity score (CSS) for all patients at admission. Within the 3 months of follow-up, the next chest CT scan was performed. As the secondary outcome, the patients with fibrotic abnormalities in their second CT scan were followed up in the next 3 months. Results Totally, 173 COVID-19 patients were finally included in the study, of whom 57 (32.9%) were male and others were female. The mean age was 53.62 ± 13.67 years old. At 3-month CT follow-up, evidence of pulmonary fibrosis was observed in 90 patients (52.0%). Consolidation (odds ratio [OR] = 2.84), severe disease (OR 2.40), and a higher CSS (OR 1.10) at admission were associated with increased risk of fibrotic abnormalities found at 3-month CT follow-up. Of 62 patients who underwent chest CT scan again at 6 months of follow-up, 41 patients (66.1%) showed no considerable changes in the fibrotic findings, while the rest of 21 patients (33.9%) showed relatively diminished lung fibrosis. Conclusion Post-COVID-19 lung fibrosis was observed in about half of the survivors. Also, patients with severe COVID-19 pneumonia were at a higher risk of pulmonary fibrosis. Moreover, consolidation, as well as a higher CSS, in the initial chest CT scan, was associated with increased risk of post-COVID-19 lung fibrosis. In addition, some patients experienced diminished fibrotic abnormalities in their chest CT on 6-month follow-up, while some others did not.

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