Functional assessment of cancer therapy questionnaire for melanoma in the Serbian population: A factor analytic approach

The aim of this study was to examine the psychometric properties of the Functional Assessment Cancer Therapy—Melanoma (FACT-M) questionnaire in the Serbian language. The FACT-M was translated into Serbian using the standard methodology after obtaining the licence from the Functional Assessment of Chronic Illness Therapy (FACIT) translation project team. This version of FACT-M was distributed to a cohort of consecutive patients with histologically confirmed high-risk skin melanoma treated at the tertiary referral center. To examine construct validity of the FACT-M in Serbian, we performed exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). The FACT-General (FACT-G) did not fit the original 4-domain structure. Instead, we accepted a 7-domain structure which, aside from physical, emotional, social and functional well-being, had domains of ‘friends’ support’, ‘illness acceptance’ and ‘fear of death’. Melanoma scale (MS) and Melanoma surgery scale (MSS) did not fit the original one-dimensional structure. The MS was observed to have 4 domains: ‘pain’, ‘skin problems’, ‘abdominal metastases’ and ‘other problems’. The MSS was observed to have 2 domains: ‘having symptoms’ and ‘no symptoms’. It is suggested that the FACT-M questionnaire is analyzed using the newly extracted domains to examine quality of life of people with high-risk melanoma in Serbia.

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Exploratory Factor Analysis of the 12-Item Functional Assessment of Chronic Illness Therapy–Spiritual Well-Being Scale in People Newly Diagnosed With Advanced Cancer

Journal of Nursing Measurement ◽

10.1891/1061-3749.22.3.404 ◽

2014 ◽

Vol 22 (3) ◽

pp. 404-420 ◽

Cited By ~ 8

Author(s):

Mei Bai ◽

Jane K. Dixon

Keyword(s):

Factor Analysis ◽

Chronic Illness ◽

Exploratory Factor Analysis ◽

Advanced Cancer ◽

Functional Assessment ◽

Well Being ◽

Newly Diagnosed ◽

Factor Pattern ◽

Chronic Illness Therapy ◽

Spiritual Well Being

Background and Purpose: The purpose of this study was to reexamine the factor pattern of the 12-item Functional Assessment of Chronic Illness Therapy–Spiritual Well-Being Scale (FACIT-Sp-12) using exploratory factor analysis in people newly diagnosed with advanced cancer. Methods: Principal components analysis (PCA) and 3 common factor analysis methods were used to explore the factor pattern of the FACIT-Sp-12. Factorial validity was assessed in association with quality of life (QOL). Results: Principal factor analysis (PFA), iterative PFA, and maximum likelihood suggested retrieving 3 factors: Peace, Meaning, and Faith. Both Peace and Meaning positively related to QOL, whereas only Peace uniquely contributed to QOL. Conclusion: This study supported the 3-factor model of the FACIT-Sp-12. Suggestions for revision of items and further validation of the identified factor pattern were provided.

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Functional Assessment of Chronic Illness Therapy--Spiritual Personal Well-being; Czech Version

PsycTESTS Dataset ◽

10.1037/t71728-000 ◽

2018 ◽

Author(s):

Gabriela Šarníková ◽

Klára Maliňáková ◽

Jana Fürstová ◽

Eva Dubovská ◽

Peter Tavel

Keyword(s):

Chronic Illness ◽

Functional Assessment ◽

Well Being ◽

Chronic Illness Therapy

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Factor Structure of Functional Assessment of Chronic Illness Therapy: Spiritual Well-Being Scale in Patients with Heart Failure Depends on Method Used

Journal of Palliative Medicine ◽

10.1089/jpm.2021.0064 ◽

2021 ◽

Vol 24 (6) ◽

pp. 807-808

Author(s):

Lubin R. Deng ◽

Kevin S. Masters ◽

Sarah J. Schmiege ◽

Edward Hess ◽

David B. Bekelman

Keyword(s):

Heart Failure ◽

Chronic Illness ◽

Factor Structure ◽

Functional Assessment ◽

Well Being ◽

Chronic Illness Therapy ◽

Patients With Heart Failure ◽

Spiritual Well Being

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Translation and validation of the Persian version of the functional assessment of chronic illness therapy—Spiritual well-being scale (FACIT-Sp) among Muslim Iranians in treatment for cancer

Palliative & Supportive Care ◽

10.1017/s1478951512000727 ◽

2012 ◽

Vol 11 (1) ◽

pp. 29-35 ◽

Cited By ~ 18

Author(s):

Najmeh Jafari ◽

Ahmadreza Zamani ◽

Mark Lazenby ◽

Ziba Farajzadegan ◽

Hamid Emami ◽

...

Keyword(s):

Chronic Illness ◽

Functional Assessment ◽

Reliability And Validity ◽

Well Being ◽

Persian Version ◽

Persian Language ◽

Chronic Illness Therapy ◽

Spiritual Well Being ◽

Related Quality ◽

Health Related

AbstractObjective:The Functional Assessment of Chronic Illness Therapy–Spiritual Well-Being (FACIT-Sp) scale is a valid and reliable instrument to provide an inclusive measure of spirituality in research and clinical practice. The aim of this study was to translate and investigate the reliability and validity of the Persian version of the FACIT-Sp.Method:The 12 item spiritual well-being subscale of the FACIT-Sp Version 4 was translated into the Persian language, Farsi, using the FACIT translation methodology. The questionnaire was administered to a diverse sample of 153 patients in treatment for cancer. Internal consistency was assessed by Cronbach's α coefficient, confirmatory factor analysis (CFA) was applied to assess construct validity, and regression analysis was used to assess the predictor role of the FACIT-Sp in health-related quality of life (HRQOL).Results:Cronbach's α reliability coefficient for the FACIT-Sp subscales ranged from 0.72 to 0.90. The CFA generally replicated the original conceptualization of the three subscales of the FACIT-Sp12 (Peace, Meaning, and Faith). All three subscales significant predicted HRQOL.Significance of results:The Persian version of the FACIT-Sp scale is a reliable and valid tool for the clinical assessment of, and research into, the spiritual well-being of Muslim Iranian and Farsi-speaking patients in other regions of the world who are in treatment for cancer.

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Use of the Functional Assessment of Cancer Therapy-Anemia (FACT-An) Instrument in Persons with MPN-Associated Myelofibrosis and Anemia

Blood ◽

10.1182/blood.v120.21.4706.4706 ◽

2012 ◽

Vol 120 (21) ◽

pp. 4706-4706

Author(s):

Stacie Hudgens ◽

Tom Tencer ◽

Robert Peter Peter Gale ◽

Zeba M. Khan

Keyword(s):

Cancer Therapy ◽

Functional Assessment ◽

Myeloproliferative Neoplasm ◽

Well Being ◽

Change Score ◽

Patient Reported Outcome ◽

Double Blind ◽

Patient Reported ◽

Outcome Index ◽

Rbc Transfusion

Abstract Abstract 4706 Background. Myeloproliferative neoplasm (MPN)-associated myelofibrosis is characterized by anemia in almost all affected persons. The Functional Assessment of Cancer Therapy (FACT) measurement system is a patient-reported outcome (PRO) developed to document symptoms to diverse aspects of cancer treatment. One FACT version, FACT-An, specifically addresses symptoms of anemia related to cancer- therapy. FACT-An has been validated in diverse cancer populations but not in MPN-associated myelofibrosis. Methods. Data were from a phase-2 randomized double-blind Bayesian “pick-the-winner” trial of pomalidomide and prednisone in subjects with MPN-associated myelofibrosis and anemia (including RBC-transfusion-dependence). Details of the study, including definitions of anemia, response, RBC-transfusion-dependence and –independence were published previously. Change in quality of life (QOL) from randomization to the last cycle of therapy was evaluated by using the FACT-An physical well-being (PWB), functional well-being (FWB), trial outcome index (TOI) and anemia (An) domains. Minimally clinically important differences (MID) were used to determine the smallest difference in scores which subjects perceived as beneficial in the FACT-An domains of interest. Subjects were classified as meeting MID for responsiveness if their change score from baseline was greater than one standard error of measurement (SEM), indicating improvement. Results. 85 subjects were studied. All FACT-An domains showed strong reliability as measured by Cronbach's alpha. 31 were classified as anemia responders by clinical and laboratory criteria. Anemia responders showed greater improvement in PWB, FWB and TOI scores than non-responders (TOI presented below) across all FACT-An domains. Improvement began at the 2nd 28 d cycle of therapy and was sustained. Conclusion. We show anemia response defined by IWG-MRT criteria correlates with improved QOL measured by the FACT-An instrument in persons with MPN-associated myelofibrosis. Disclosures: Tencer: Celgene Corporation: Employment. Gale:Celgene Corporation: Employment. Khan:Celgene: Employment.

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Improvement in symptoms and quality of life (QoL) for patients (p) with non-small cell lung cancer (NSCLC) treated with erloninib: TargeT study

Journal of Clinical Oncology ◽

10.1200/jco.2007.25.18_suppl.18140 ◽

2007 ◽

Vol 25 (18_suppl) ◽

pp. 18140-18140

Author(s):

V. Alberola ◽

O. Gallego ◽

G. López-Vivanco ◽

C. Mesía ◽

J. Oramas ◽

...

Keyword(s):

Quality Of Life ◽

Lung Cancer ◽

Cancer Therapy ◽

Functional Assessment ◽

Objective Response ◽

Well Being ◽

End Point ◽

Trial Outcome Index ◽

Outcome Index

18140 Background: Erlotinib is an EGFR TKI that is effective in the treatment of advanced NSCLC, in terms of longer survival, better quality of life and delayed symptom progression.We present here the outcome of a group of p from the TargeT study, whose QoL was assessed by the Functional Assessment of Cancer Therapy-Lung (FACT-L) questionnaire and the Lung Cancer Subscale (LCS). Methods: TargeT study was a multicenter, single-arm phase II study evaluating efficacy, safety, and tolerability of erlotinib (150 m/day) in p with stage IIIB or IV NSCLC, in 1st, 2nd and 3rd line treatment. Primary end-point was time to progression. QoL was a secondary end point as assessed monthly by the Functional Assessment of Cancer Therapy-Lung questionnaire (FACT- L) and its Lung Cancer Subscale. Physical and functional aspects of the QoL were measured by the Trial Outcome Index (TOI), which is the sum of the physical well being, functional well-being and LCS scores from the FACT-L questionnaire. Results: Data from 91 pts were available. QoL analysis showed that 53% of the p (95% IC 37–58%) had improvement in FACT-L or TOI. Similarly, 45% (95% IC35–56%) of improved their symptoms from baseline. Improvement was observed for each individual LCS item and specifically in the pulmonary items. In symptomatic p, shortened of breath was 17,6% at baseline vs 2.2% after treatment (p<0.001) and cough was 24.7% vs 8.8 % (p<0.001) after treatment. Those improvements in symptoms were rapid and, 73% of the patients who improved showed that recovery in the first cycle of treatment. In terms of association between efficacy of erlotinib and QoL, there is a statistically significative relationship between objective response and improvement in TOI or FACT-L (p<0.02). Conclusions: This QoL analysis confirms that erlotinib improves both symptoms and functional aspect of patients with NSCLC. The improvement in QoL is related with objective response. No significant financial relationships to disclose.

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QOL assessment integrated into the clinical care of cancer survivors to identify needs and direct care.

Journal of Clinical Oncology ◽

10.1200/jco.2019.37.15_suppl.6611 ◽

2019 ◽

Vol 37 (15_suppl) ◽

pp. 6611-6611

Author(s):

Christian S. Adonizio ◽

Jamie Weeder ◽

Erin Benner ◽

Jesse Manikowski ◽

Julie Hergenrather ◽

...

Keyword(s):

High Risk ◽

Cancer Therapy ◽

Cancer Survivors ◽

Clinical Care ◽

Well Being ◽

Direct Care ◽

Care Plan ◽

Survivorship Care Plan ◽

Curative Intent ◽

Curative Therapy

6611 Background: Validated survey tools have been used to measure the quality of life (QOL) of patients treated for cancer, however, there are newer studies that have shown both an improvement in QOL, and improvement in overall survival using these tools. We integrated the Functional Assessment of Cancer Therapy – General Population (FACT-GP v.4) to direct the deployment of resources and interventions to improve the care of patients who have completed potentially curative therapy for cancer. Methods: This is an observational study of patients who received cancer therapy with curative intent in the last 18 months. The FACT-GP was administered by an RN via telephone. Patients contacted received and reviewed a Survivorship Care Plan (SCP) as defined by the American College of Surgeons Committee on Cancer. Patients who had a total score less than 60 on FACT-GP and/or had a score less than 12 on the Emotional Well-Being subscale (EWB) were considered high-risk and were referred to the Survivorship MDC for in-person evaluation. Results: From 10/1/2018 to 12/31/2018, 114 patients were referred to the cancer survivorship program. Of these, 64 (56%) patients had FACT-GP administered and were evaluated. 45 of these (70%) only completed the FACT-GP and received an SCP. 21 patients had a total score less than 60 and/or an EWB sub-score less than 12 and were identified as high-risk. 15 (72%) patients were seen in MDC, 4 (19%) patients were seen in conjunction with a scheduled appointment by the MDC team, 2 (9%) patients refused further evaluation. 66.7% of patients in the survivorship program were referred to Oncology Behavioral Health compared to 18.2% of all oncology patients. Survivorship patients in the cohort had a baseline utilization of the emergency department (ED) of 4.1% (10 of 241) from 1/1/2018 to 9/30/2018 and 0 (0 of 64) after the initiation of the intervention from 10/1/2018 to 12/31/2018. Conclusions: Integrating a validated QOL tool (FACT-GP) as a therapeutic intervention is feasible and may both identify needs and direct services for cancer survivors while possibly decreasing ED utilization. Clinical trial information: NCT03835052.

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