scholarly journals Olive oil intake and cancer risk: A systematic review and meta-analysis

PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0261649
Author(s):  
Christos Markellos ◽  
Maria-Eleni Ourailidou ◽  
Maria Gavriatopoulou ◽  
Panagiotis Halvatsiotis ◽  
Theodoros N. Sergentanis ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Risk ◽  
Cohort Studies ◽  
Cancer Prevention ◽  
Olive Oil ◽  
Meta Analysis ◽  
Univariate Analysis ◽  
Sensitivity Analyses ◽  
Oil Consumption ◽  
Incident Cases

Background Research evidence has established the beneficial effects of diet in cancer prevention; various epidemiological studies have suggested that olive oil component could play a role in decreasing cancer risk. This systematic review and meta-analysis aims to investigate the association between olive oil consumption, cancer risk and prognosis. Methods A systematic search was conducted in PubMed, EMBASE and Google Scholar databases (end-of-search: May 10, 2020). Pooled relative risk (RR) and 95% confidence intervals (95% CIs) were estimated with random-effects (DerSimonian-Laird) models. Subgroup analyses, sensitivity analyses and meta-regression analysis were also performed. Results 45 studies were included in the meta-analysis; 37 were case-control (17,369 cases and 28,294 controls) and 8 were cohort studies (12,461 incident cases in a total cohort of 929,771 subjects). Highest olive oil consumption was associated with 31% lower likelihood of any cancer (pooled RR = 0.69, 95%CI: 0.62–0.77), breast (RR = 0.67, 95%CI: 0.52–0.86), gastrointestinal (RR = 0.77, 95%CI: 0.66–0.89), upper aerodigestive (RR = 0.74, 95%CI: 0.60–0.91) and urinary tract cancer (RR = 0.46, 95%CI: 0.29–0.72). Significant overall effects spanned both Mediterranean and non-Mediterranean participants, studies presenting a multivariate and a univariate analysis and all subgroups by study quality. Conclusions Olive oil consumption seems to exert beneficial actions in terms of cancer prevention. Additional prospective cohort studies on various cancer types and survivors, as well as large randomized trials, seem desirable.

scholarly journals Occupational Asbestos Exposure and Kidney Cancer: Systematic Review and Meta-analysis of Cohort Studies

2020 ◽  
Author(s):  
Chris C Y Pang ◽  
Kevin Phan ◽  
Md Nazmul Karim ◽  
Afsana Afroz ◽  
Matthew Winter ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Kidney Cancer ◽  
Meta Analysis ◽  
Asbestos Exposure ◽  
International Agency ◽  
Standardized Mortality Ratio ◽  
Significant Heterogeneity ◽  
Incidence Studies ◽  
Incident Cases

Abstract Objectives An estimated 125 million workers are exposed to asbestos worldwide. Asbestos is classified by the International Agency for Research on Cancer as a Group 1 carcinogen. The association between occupational asbestos exposure and kidney cancer is not well established however. This study aimed to determine the mortality and incidence of kidney cancer in workers who have been exposed to asbestos. We performed a systematic review and meta-analysis to evaluate the association between occupational asbestos exposure and kidney cancer. Methods Medline, EMBASE, and Web of Science were searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for articles on occupational asbestos exposure and kidney cancer. The studies reported the standardized mortality ratio (SMR) or standardized incidence ratio (SIR) of kidney cancer in workers exposed to asbestos. SMRs or SIRs with its 95% confidence interval (CI) were pooled using a fixed-effect model. Results Forty-nine cohort studies involving 335 492 workers were selected for analysis. These studies included 468 kidney cancer deaths and 160 incident cases. The overall pooled-SMR of kidney cancer was 0.95 (95% CI: 0.86–1.05), with no significant heterogeneity (PQ = 0.09, I2 = 24.87%). The overall pooled-SIR of kidney cancer was 0.95 (95% CI: 0.79–1.11), with no significant heterogeneity (PQ = 0.68, I2 = 0.00%). Subgroup analysis did not find any increased association with occupational asbestos exposure. There was no evidence of publication bias with Egger’s test P values of 0.08 for mortality studies and 0.99 for incidence studies. Conclusions This systematic review and meta-analysis did not show evidence of association between occupational asbestos exposure and kidney cancer mortality or incidence.

scholarly journals Dairy products and colorectal cancer risk: a systematic review and meta-analysis of cohort studies

2012 ◽  
Vol 23 (1) ◽  
pp. 37-45 ◽  
Author(s):  
D. Aune ◽  
R. Lau ◽  
D.S.M. Chan ◽  
R. Vieira ◽  
D.C. Greenwood ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Risk ◽  
Cohort Studies ◽  
Dairy Products ◽  
Meta Analysis ◽  
Colorectal Cancer Risk

scholarly journals Global Incidence of Necrotizing Enterocolitis: a Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Amer Alsaied ◽  
Nazmul Islam ◽  
Lukman Thalib
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Publication Bias ◽  
Necrotizing Enterocolitis ◽  
Meta Analysis ◽  
Sensitivity Analyses ◽  
Cochrane Library ◽  
Vlbw Infants ◽  
Funnel Plots ◽  
Substantial Heterogeneity

Abstract Background: Necrotizing Enterocolitis (NEC) is a major cause of morbidity and mortality in the Neonatal Intensive Care Unit (NICU), yet the global incidence of NEC has not been systematically evaluated. We conducted a systematic review and meta-analysis of cohort studies reporting the incidence of NEC in infants with Very Low Birth Weight (VLBW).Methods: The databases searched included PubMed, MEDLINE, the Cochrane Library, EMBASE and grey literature. Eligible studies were cohort or population-based studies of newborns including registry data reporting incidence of NEC. Data were extracted from the selected papers included incidence of NEC cases and size of population at risk, author and publication details, follow up period covered by the study, location and setting of the study and whether it was VLBW infants or preterm infants. Additionally, risk of bias assessment of the included studies were carried out using a validated tool. Bias adjusted Quality Effect Model (QEM) were used to pool the estimates. In the presence of substantial heterogeneity, Random Effect Models (REM) were used as an additionally sensitivity analyses. The heterogeneity between studies were evaluated using the Cochrane Q statistics and Higgin’s I2 value. Subgroup analysis and meta-regression were used to explore the sources of heterogeneity. Funnel plots as appropriate for ratio measures were used to assess publication bias. Results: A systematic and comprehensive search of databases identified 27 cohort studies reporting the incidence of NEC. The pooled estimate of the global incidence of NEC was 6.0% (95% CI: 4.0%-9.0%). There were substantial heterogeneity (I2 = 100%) between studies. Funnel plots showed no evidence of publication bias.Conclusion: Seven out of 100 of all VLBW infants in NICU are likely to develop NEC. However, there were considerable heterogeneity between studies. High quality studies assessing incidence of NEC along with associated risk factors are warranted.

The risk of developing major depression among individuals with subthreshold depression: a systematic review and meta-analysis of longitudinal cohort studies

2018 ◽  
Vol 49 (1) ◽  
pp. 92-102 ◽  
Author(s):  
Y. Y. Lee ◽  
E. A. Stockings ◽  
M. G. Harris ◽  
S. A. R. Doi ◽  
I. S. Page ◽  
...  
Keyword(s):  
Systematic Review ◽  
Major Depression ◽  
Cohort Studies ◽  
Meta Analysis ◽  
Sensitivity Analyses ◽  
Subthreshold Depression ◽  
Age Group ◽  
Increased Risk ◽  
Subgroup Analyses ◽  
Study Heterogeneity

AbstractBackgroundStudies have consistently shown that subthreshold depression is associated with an increased risk of developing major depression. However, no study has yet calculated a pooled estimate that quantifies the magnitude of this risk across multiple studies.MethodsWe conducted a systematic review to identify longitudinal cohort studies containing data on the association between subthreshold depression and future major depression. A baseline meta-analysis was conducted using the inverse variance heterogeneity method to calculate the incidence rate ratio (IRR) of major depression among people with subthreshold depression relative to non-depressed controls. Subgroup analyses were conducted to investigate whether IRR estimates differed between studies categorised by age group or sample type. Sensitivity analyses were also conducted to test the robustness of baseline results to several sources of study heterogeneity, such as the case definition for subthreshold depression.ResultsData from 16 studies (n= 67 318) revealed that people with subthreshold depression had an increased risk of developing major depression (IRR = 1.95, 95% confidence interval 1.28–2.97). Subgroup analyses estimated similar IRRs for different age groups (youth, adults and the elderly) and sample types (community-based and primary care). Sensitivity analyses demonstrated that baseline results were robust to different sources of study heterogeneity.ConclusionThe results of this study support the scaling up of effective indicated prevention interventions for people with subthreshold depression, regardless of age group or setting.

Sa243 GASTRIC CANCER RISK OF INTESTINAL METAPLASIA SUBTYPES: A SYSTEMATIC REVIEW AND META-ANALYSIS OF COHORT STUDIES

2021 ◽  
Vol 160 (6) ◽  
pp. S-462-S-463
Author(s):  
Sijing Du ◽  
Yang Yang ◽  
Shuangshuang Fang ◽  
Song Guo ◽  
Chuchu Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
Cancer Risk ◽  
Cohort Studies ◽  
Intestinal Metaplasia ◽  
Meta Analysis ◽  
Gastric Cancer Risk
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