scholarly journals Effects of Hyperlipidemia on Plasma Sodium, Potassium, and Chloride Measurements by an Indirect Ion-Selective Electrode Measuring System

2006 ◽  
Vol 52 (1) ◽  
pp. 155-156 ◽  
Author(s):  
Goce Dimeski ◽  
Peter Mollee ◽  
Andrew Carter
Keyword(s):  
Ion Selective Electrode ◽  
Measuring System ◽  
Plasma Sodium ◽  
Selective Electrode ◽  
Sodium Potassium

Discrepancies Between Sodium Concentrations Measured by the Kodak Ektachem 700 and by Dilutional and Direct Ion-Selective Electrode Analyzers

1992 ◽  
Vol 38 (12) ◽  
pp. 2419-2422 ◽  
Author(s):  
J A Stone ◽  
J R Moriguchi ◽  
D R Notto ◽  
P E Murphy ◽  
C J Dass ◽  
...  
Keyword(s):  
Total Protein ◽  
Benzalkonium Chloride ◽  
Gamma Globulin ◽  
Ion Selective Electrode ◽  
Plasma Sodium ◽  
Selective Electrode ◽  
Sodium Potassium ◽  
Clinically Significant

Abstract We have identified rare (approximately 0.2% of all samples), but clinically significant, discrepancies between serum or plasma sodium concentrations measured with the Kodak Ektachem 700's direct ion-selective electrode (ISE) method and concentrations measured with two other analyzers: the Beckman Synchron CX3's dilutional ISE instrument and the Radiometer KNA2 instrument for sodium-potassium analysis by the direct ISE method. The differences do not appear to be related to any previously identified sources of discrepancy, such as variations in triglycerides, bicarbonate, total protein, albumin, or gamma-globulin, the presence of paraproteins, or interference by benzalkonium chloride from heparinized catheters. They occurred despite the use of Gen 04 reference fluid on the Ektachem. We could not identify any drug or family of drugs that the patients had taken in common and that might influence the results. Until this problem is resolved, Ektachem users should be aware of the potential for discrepancies of > 6 mmol/L in measurements of sodium concentrations.

Evaluation of an Automated Selective-Ion Electrolyte Analyzer for Measuring Na+, K+, and Cl- in Serum

1974 ◽  
Vol 20 (9) ◽  
pp. 1217-1221 ◽  
Author(s):  
Jack A Lustgarten ◽  
Robert E Wenk ◽  
Charles Byrd ◽  
Barbara Hall
Keyword(s):  
Clinical Setting ◽  
Ion Selective Electrode ◽  
Ion Selective Electrodes ◽  
Selective Electrode ◽  
Sodium Potassium ◽  
Comparison Methods ◽  
Flame Emission ◽  
Coefficients Of Variation

Abstract An automated analyzer, in which ion-selective electrodes are used to measure sodium, potassium, and chloride in serum, was assessed in a clinical setting. Day-to-day precision, evaluated by replicate analysis of serum pools, yielded the following coefficients of variation for sodium, potassium, and chloride, respectively: 0.99%, 1.39%, and 0.67%. Values for chloride in both commercial control sera and aqueous standards were linearly related to concentration over a range of at least 10-220 mmol/liter; however, results with the potassium and sodium electrodes showed slight curvilinearity over the range 0-24 and 10-220 mmol/liter, respectively. Mean recoveries for sodium, potassium, and chloride for concentrations covering the clinically important ranges were 98.3-102.3%, 95.9-100.0%, and 97.8-102.0%. The only important differences between experimental and comparison methods in sera were falsely high values obtained with the ion-selective electrode for K+ (caused by supranormal ammonia concentrations) and for Cl- (caused by administered bromide). Mean sodium and chloride values obtained with the electrode did not differ significantly from values obtained by flame-emission photometry or coulometry for duplicate patients’ specimens, but potassium values did differ slightly (P = .05).

Lithium determined in serum with an ion-selective electrode.

1988 ◽  
Vol 34 (7) ◽  
pp. 1500-1502 ◽  
Author(s):  
R L Bertholf ◽  
M G Savory ◽  
K H Winborne ◽  
J C Hundley ◽  
G M Plummer ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Regression Line ◽  
Isotope Dilution Mass Spectrometry ◽  
Lithium Ion ◽  
Ion Selective Electrode ◽  
Flame Photometry ◽  
Selective Electrode ◽  
Serum Samples ◽  
Sodium Potassium ◽  
Significant Interference

Abstract We evaluated the performance of the lithium ion-selective electrode (ISE) in the Du Pont Na/K/Li analyzer. Lithium concentrations in 106 serum samples from patients being treated with lithium were measured in duplicate with the ISE and by flame photometry. The slope of the regression line for the two methods was 1.004 with a standard error of the estimate of 0.049 mmol/L (x = flame photometry, y = ISE). Lithium measurements by the ISE method in serum or aqueous standards were linear to greater than 2.0 mmol/L. Within-run CVs for low (0.31 mmol/L) and high (1.15 mmol/L) lithium controls were 5.9% and 1.7%, respectively (n = 20). Day-to-day CVs for the same controls were 9.8% and 3.3%, respectively (n = 20). There was no significant interference when the concentrations of sodium, potassium, calcium, or magnesium were varied, nor did intervening urinary lithium analyses affect the measurement of serum lithium. Results for lithium measurement in four serum-based survey materials compared well with results by isotope dilution/mass spectrometry.

The Technicon RA-1000 evaluated for measuring sodium, potassium, chloride, and carbon dioxide.

1985 ◽  
Vol 31 (3) ◽  
pp. 435-438 ◽  
Author(s):  
R H Ng ◽  
M Altaffer ◽  
R Ito ◽  
B E Statland
Keyword(s):  
Carbon Dioxide ◽  
Potassium Chloride ◽  
Colorimetric Method ◽  
Random Access ◽  
Potentiometric Method ◽  
Ion Selective Electrode ◽  
Selective Electrode ◽  
Sodium Potassium ◽  
High Concentrations

Abstract We evaluated the Technicon RA-1000 "random-access" analyzer for the measurements of sodium, potassium, and carbon dioxide by an indirect potentiometric method (ion-selective electrode) and for chloride by a colorimetric method (mercuric thiocyanate). For various concentrations of control materials the total precision (CV) ranged from 0.9 to 1.2% for sodium, 1.1 to 1.3% for potassium, 1.0 to 1.2% for chloride, and 2.8 to 3.8% for carbon dioxide. The system demonstrated acceptable performance in linearity and carryover. Patients' results from the RA-1000 correlated well with those from the Beckman ASTRA-8. In a study on potential interferences, we found that high concentrations of salicylate and bromide significantly affected measurements of carbon dioxide and chloride, respectively. The RA-1000 requires only 30 microL of sample for all four tests and it offers a high throughout (30 specimens analyzed for the four tests in 25 min). This precise, easy-to-use, random-access analyzer requires minimal maintenance.

scholarly journals Hubungan Kadar Elektrolit Dengan Petanda Jantung Pada Sindrom Koroner Akut

2020 ◽  
Vol 7 (1) ◽  
pp. 27-33
Author(s):  
Emelia Wijayanti ◽  
Purwanto Adipireno
Keyword(s):  
Potassium Chloride ◽  
Negative Correlation ◽  
Troponin I ◽  
Fluorescence Assay ◽  
Ion Selective Electrode ◽  
Cardiac Markers ◽  
Serum Electrolyte ◽  
Selective Electrode ◽  
Sodium Potassium ◽  
Immuno Assay

Pendahuluan: Sindrom koroner akut (SKA) merupakan masalah kardiovaskular utama yang menyebabkan angka perawatan dan kematian yang tinggi. Enzim jantung seperti troponin dan Creatinin Kinase-MB (CKMB) dilepaskan ke peredaran darah dan meningkat pada infark miokard. Elektrolit adalah zat berfungsi untuk menghantarkan listrik. Aktivitas listrik jantung diatur oleh kalsium, kalium dan natrium; kontraksi jantung membutuhkan kalsium, magnesium dan fosfor. Elektrolit berguna sebagai indikator AMI. Penelitian ini bertujuan menganalisis kadar serum elektrolit dengan petanda jantung pada SKA. Metode: Penelitian belah lintang pada 35 pasien SKA pada bulan Desember - Januari 2018. Kadar elektrolit serum diperiksa dengan metode Ion selective electrode (ISE) dan photometric, kadar CKMB diperiksa dengan metode Enzyme-linked immuno assay (ELISA), kadar Troponin I (cTnI) diperiksa dengan metode Enzyme-linked fluorescence assay (ELFA). Uji Korelasi spearman digunakan untuk menganalisis data, signifikan jika p <0.05. Hasil: Terdapat korelasi negatif kuat antara natrium, kalium, clorida, dan magnesium baik dengan CKMB (p 0,000/ 0,000/ 0,001/ 0,014 dan r= -0,631/ -0,634/ -0,557/ -0,412) maupun cTnI (p 0,000/ 0,000/ 0,001/ 0,000 dan r= -0,746/ -0,574/ -0,545/ -0,564). Tidak terdapat korelasi antara kalsium baik dengan CKMB (p= 0,475 dan r= -0,125) maupun cTnI (p= 0,086 dan r= -0,294). Simpulan: Terdapat hubungan negatif antara natrium, kalium, clorida, dan magnesium dengan petanda jantung, tidak terdapat hubungan antara kalsium dengan petanda jantung pada SKA. Temuan ini menunjukkan bahwa rendahnya kadar serum elektrolit pada SKA dapat berarti adanya area infark yang lebih luas. Hasil penelitian ini perlu divalidasi dalam penelitian berskala besar dengan metodologi yang lebih baik dan diharapkan dapat menjadi dasar penelitian lebih lanjut. Kata Kunci: SKA, Elektrolit, CKMB, cTnI   Introduction: Acute coronary syndrome (ACS) is a major cardiovascular problem that causes significant morbidity and mortality burden. Cardiac enzymes, such as troponin and Creatinin Kinase-MB (CKMB), are released into the bloodstream and increase in acute myocardial infarction (AMI). Electrolytes involving calcium, potassium and sodium regulate heart electrical activity, while calcium, magnesium and phosphorus regulate its contraction. Electrolytes serve as AMI indicators. This study aims to analyze serum electrolyte levels with cardiovascular markers in ACS. Methods: a coss sectional study of 35 ACS patients was conducted from December to January 2018. Serum electrolyte levels were examined by the Ion selective electrode (ISE) and photometric method, CKMB levels were examined by the enzyme-linked immuno assay (ELISA), Troponin I (cTnI) were examined by the Enzyme-linked fluorescence assay (ELFA) method. Spearman test was perfomed for analyzing data with significant level of  <0.05. Results: a strong negative correlation was found between sodium, potassium, chloride, and magnesium and both CKMB (p 0,000 / 0,000 / 0,001 / 0,014 and r = -0,631 / -0,634 / -0,557 / -0,412) and cTnI (p 0,000 / 0,000 / 0.001 / 0,000 and r = -0,746 / -0,574 / -0,545 / -0,564). No correlation was found between calcium and both CKMB (p = 0.475 and r = -0.125) and cTnI (p = 0.086 and r = -0.294). Conclusion: There is significant negative correlation between sodium, potassium, chloride, and magnesium and cardiac markers, there is no correlation between calcium and cardiac markers in ACS. These findings indicate low serum electrolytes values in ACS may have higher area of infarction. These finding need to be validated in large-scale studies with better methodologies and are expected to be the basis for further research. Keywords:  ACS, Electrolytes, CKMB, cTnI.

STUDY OF SERUM ELECTROLYTES IMBALANCES IN FEMALE THYROID PATIENTS AT AIIMS, PATNA: A HOSPITAL BASED COMPARATIVE STUDY.

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Dr. Jyoti Kumari ◽  
Dr. Dev Kant ◽  
Dr. Mala Mahto
Keyword(s):  
Standard Deviation ◽  
Early Detection ◽  
P Value ◽  
Selective Electrode ◽  
Serum Electrolytes ◽  
Sodium Potassium ◽  
Paired Samples ◽  
Electrode Method ◽  
Hypothyroid Patients ◽  
Key Words Hypothyroidism

Objectives: This present study was to compare the serum electrolytes (Na, K and Cl) imbalances in hypothyroidism, hyperthyroidism with euthyroidism female cases. Methods: A detail history, clinical examinations and relevant investigations were performed to all female thyroid cases. Thyroid hormones were estimated by chemiluminiscence method using Siemens Advia Centaur XP instrument. Electrolyte levels (Na+, k+ & Cl-) were measured by ion selective electrode method using Eschweiler combi. Results: Data was analyzed with the help of SPSS (version 26) software. Paired samples statistics was used. Mean ± standard deviation and t value were calculated. P value was taken less than or equal to 0.05 (p ≤ 0.05) for significant differences. Conclusions: This present study concluded that electrolytes sodium, potassium and chloride levels were significantly reduced in hypothyroidism female cases compared to euthyroids female (controls). This suggests that hypothyroid patients should be regularly checked for serum electrolytes. Early detection and treatment can prevent the further complications related to the disorder and will be helpful during the management of thyroid patients. Key words: Hypothyroidism, hyperthyroidism, euthyroidism, electrolytes.

Sign in / Sign up

Export Citation Format

Share Document