scholarly journals Plasma Adiponectin and the Risk of Hypertension in White and Black Postmenopausal Women

2012 ◽  
Vol 58 (10) ◽  
pp. 1438-1445 ◽  
Author(s):  
Lu Wang ◽  
JoAnn E Manson ◽  
J Michael Gaziano ◽  
Simin Liu ◽  
Barbara Cochrane ◽  
...  
Keyword(s):  
Black Women ◽  
Postmenopausal Women ◽  
White Women ◽  
Case Control Study ◽  
Plasma Concentrations ◽  
Case Control ◽  
Inverse Association ◽  
Plasma Adiponectin ◽  
Nested Case Control ◽  
Control Study

Abstract BACKGROUND Adiponectin may have a protective role in the development of obesity-related metabolic and vascular disorders, including hypertension. We conducted a prospective, nested case control study to investigate the relation between baseline plasma adiponectin, measures of adiposity, and subsequent risk of hypertension. METHODS We selected 400 white and 400 black postmenopausal women, age <70 years, who developed incident hypertension during 5.9-year follow-up and an equal number of age- and race-matched controls in the Women's Health Initiative Observational Study. We measured plasma concentrations of total adiponectin in their baseline blood samples. RESULTS In crude matched models, plasma adiponectin was inversely associated with risk of hypertension among both white and black women. The association appeared to be nonlinear in white women but dose related in black women. Adjustment for lifestyle factors, measures of obesity, and obesity-related clinical factors attenuated these associations. The multivariable relative risk (95% CI) of hypertension across increasing quartiles of plasma adiponectin were 1.00, 0.98 (0.66–1.46), 0.63 (0.41–0.97), and 0.92 (0.60–1.42) in white women (Ptrend: 0.38) and 1.00, 0.96 (0.64–1.46), 0.83 (0.53–1.29), and 0.58 (0.36–0.94) in black women (Ptrend: 0.02). Further adjustment for inflammatory markers and endothelial markers eliminated the association in white, but not black, women. CONCLUSIONS In this prospective, nested case control study, we found an inverse association between plasma adiponectin and risk of hypertension in white and black postmenopausal women. The reduced risk of hypertension was limited to only intermediate concentrations of adiponectin in white women whereas it was graded across quartiles of adiponectin in black women.

scholarly journals Plasma adiponectin levels, ADIPOQ variants, and incidence of type 2 diabetes: A nested case-control study

2017 ◽  
Vol 127 ◽  
pp. 254-264 ◽  
Author(s):  
Atsushi Goto ◽  
Mitsuhiko Noda ◽  
Maki Goto ◽  
Kazuki Yasuda ◽  
Tetsuya Mizoue ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Case Control Study ◽  
Case Control ◽  
Plasma Adiponectin ◽  
Nested Case Control ◽  
Control Study

scholarly journals 794Bisphosphonate use and risk of ovarian cancer, a nested case-control study using national health data

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Karen Tuesley ◽  
Penelope Webb ◽  
Melinda Protani ◽  
Katrina Spilsbury ◽  
Sallie-Anne Pearson ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Case Control Study ◽  
Epidemiological Studies ◽  
Case Control ◽  
Sensitivity Analyses ◽  
Prescription Data ◽  
Inverse Association ◽  
Australian State ◽  
Nested Case Control ◽  
Control Study

Abstract Background Epithelial ovarian cancer (EOC) is the eighth most common cancer in women, has a five-year survival of ∼45%, and very few established modifiable risk factors. Some evidence suggests that bisphosphonates could have chemopreventive benefits, but few epidemiological studies have investigated the association between bisphosphonate use and incidence of EOC. Methods We conducted a nested case-control study using linked administrative data. We identified 9,367 women over 50 years diagnosed with EOC (cases) from 2004 to 2013, and for each case identified five controls from the Australian Medicare Enrolment database matched by age, state, area of residence, and area-level socioeconomic disadvantage. We assessed the associations between bisphosphonate use using dispensed prescription data (ever use, duration and dose) and EOC (overall, by histotype), adjusting for comorbidities and MHT use. We conducted sensitivity analyses in women with complete ascertainment of dispensing claims and for residents of one Australian state that had linked with data linked to hospital procedures, including oophorectomy. Results Our analyses show an inverse association between bisphosphonate use and risk of EOC overall (OR = 0.81, 95%CI:0.75-0.88), and for endometrioid (OR = 0.51, 95%CI:0.33-0.79) and serous (OR = 0.84, 95%CI:0.75-0.93) histotypes. There was some evidence that higher dose and duration were associated with a greater reduction in risk. Results from sensitivity analyses were not appreciably different. Conclusions Bisphosphonate use was associated with lower risk of EOC, suggesting bisphosphonates may reduce risk of ovarian cancer development. Key messages Bisphosphonates may protect against development of serous and endometrioid ovarian cancers.

scholarly journals Abstract 4216: Adiponectin, leptin and breast cancer in high risk postmenopausal women: Results from a nested case-control study

2018 ◽  
Author(s):  
Debora Macis ◽  
Ivana Sestak ◽  
Valentina Aristarco ◽  
Harriet Johansson ◽  
Aliana Guerrieri-Gonzaga ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Postmenopausal Women ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

Fruits, Vegetables, Soy Foods and Breast Cancer in Pre- and Postmenopausal Korean Women: A Case-Control Study

2007 ◽  
Vol 77 (2) ◽  
pp. 130-141 ◽  
Author(s):  
Do ◽  
Lee ◽  
Kim ◽  
Jung ◽  
Lee
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Postmenopausal Women ◽  
Case Control Study ◽  
Case Control ◽  
Inverse Association ◽  
Korean Women ◽  
Soy Foods ◽  
Control Study

We carried out a case-control study to examine the relationship between fruits, vegetables, and soy foods intake with breast cancer risk in Korean women. Incident cases (n = 359) were identified through cancer biopsies and hospital-based controls (n = 708) were selected in the same hospitals. Subjects were asked to indicate usual dietary habits, which were assessed using a semi-quantitative food frequency questionnaire (98 items). Odds ratio (OR) and 95% confidence intervals (95% CI) were calculated by unconditional logistic regression after adjustment for additional confounding factors according to the menopausal status. High grape intake showed an inverse association of breast cancer in postmenopausal women (OR = 0.59, 95% CI = 0.35–0.95; p for trend = 0.05). High tomato intake was associated with reduced breast cancer risk in premenopausal women (OR = 0.59, 95% CI = 0.38–0.89, p for trend = 0.04). In postmenopausal women, green pepper intake showed an inverse association of breast cancer risk (OR = 0.60, 95% CI = 0.43–0.96, p for trend = 0.03). High soybean intake showed an inverse association of breast cancer in postmenopausal women (OR = 0.61, 95% CI = 0.34–0.89, p for trend = 0.02). Our study suggests that high intake of some fruits, vegetables, and soybeans may be associated with a reduced breast cancer risk.

Association between dietary total antioxidant capacity and breast cancer: a case–control study in a Middle Eastern country

2020 ◽  
pp. 1-8
Author(s):  
Bahareh Sasanfar ◽  
Fatemeh Toorang ◽  
Farzad Maleki ◽  
Ahmad Esmaillzadeh ◽  
Kazem Zendehdel
Keyword(s):  
Breast Cancer ◽  
Antioxidant Capacity ◽  
Postmenopausal Women ◽  
Total Antioxidant Capacity ◽  
Case Control Study ◽  
Case Control ◽  
Inverse Association ◽  
Total Antioxidant ◽  
Control Study ◽  
Dietary Total Antioxidant Capacity

Abstract Objective: The aim of this study was to determine the relationship between dietary total antioxidant capacity (dTAC) and risk of breast cancer among Iranian women. Design: In this hospital-based case–control study, dietary intake of participants was collected using a 168-item validated FFQ. Dietary TAC was assessed using FRAP assay considering. Logistic regression was used to obtain ORs for breast cancer across quartiles of dTAC. Setting: Cancer Institute, Iran. Participants: We included 412 women with pathologically confirmed breast cancer and 456 apparently healthy controls. Results: Mean dTAC was 11·3 ± 5·8 for cases and 12·1 ± 7·9 for controls. A trend towards significant inverse association was seen between dTAC and odds of breast cancer in the whole population; such that after controlling for several potential confounders, individuals in the highest quartile of dTAC were 0·39 times less likely to have breast cancer than those in the lowest quartile (0·61; 95 % CI: 0·38, 0·99, P < 0·05). In the stratified analysis by menopausal status, we found that postmenopausal women with the greatest dTAC had lower odds for breast cancer, compared with those with the lowest dTAC (0·47; 95 % CI: 0·24, 0·93, P < 0·05). This association strengthened after additional adjustment for BMI (0·28; 95 % CI: 0·11, 0·72, P < 0·05). No significant association was seen between dTAC and odds of breast cancer in premenopausal women. Conclusions: We found that dietary TAC was inversely associated with risk of breast cancer, in particular among postmenopausal women. Prospective cohort studies are needed to confirm these findings.

scholarly journals Acrylamide and glycidamide hemoglobin adduct levels and endometrial cancer risk: A nested case-control study in nonsmoking postmenopausal women from the EPIC cohort

2015 ◽  
Vol 138 (5) ◽  
pp. 1129-1138 ◽  
Author(s):  
Mireia Obón-Santacana ◽  
Heinz Freisling ◽  
Petra H. Peeters ◽  
Leila Lujan-Barroso ◽  
Pietro Ferrari ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Postmenopausal Women ◽  
Case Control Study ◽  
Case Control ◽  
Endometrial Cancer Risk ◽  
Nested Case Control ◽  
Control Study
Sign in / Sign up

Export Citation Format

Share Document