scholarly journals Toward a Comprehensive Developmental Model for Alcohol Use Disorders in Men

2011 ◽  
Vol 14 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Kenneth S. Kendler ◽  
Charles O. Gardner ◽  
Carol A. Prescott
Keyword(s):  
Risk Factors ◽  
Alcohol Use ◽  
Social Factors ◽  
Complex Traits ◽  
Internalizing Symptoms ◽  
Peer Group ◽  
Alcohol Use Disorders ◽  
Developmental Model ◽  
Minor Role ◽  
Late Adolescent

The multiple risk factors for alcohol use (AU) and alcohol use disorders (AUDs) are interrelated through poorly understood pathways, many of which begin in childhood. In this report, the authors seek to develop an empirical, broad-based developmental model for the etiology of AU and AUDs in men. We assessed 15 risk factors in four developmental tiers in 1,794 adult male twins from the Virginia population based twin registry. The best fitting model explained 39% of the variance in late adolescent AU, and 30% of the liability to lifetime symptoms of AUD. AU and AUDs can be best understood as arising from the action and interaction of two pathways reflecting externalizing genetic/temperamental and familial/social factors. Peer group deviance was important in each pathway. Internalizing symptoms played a more minor role. Familial/social factors were especially important influences on AU, while genetic/temperamental factors were more critical for AUDs. We conclude that AU and AUDs in men are complex traits influenced by genetic, family, temperamental, and social factors, acting and interacting over developmental time.

scholarly journals Evaluation of childhood traumatic experience as a risk factor for alcohol use disorder in adulthood

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Lan Wang ◽  
Cui-Xia An ◽  
Mei Song ◽  
Na Li ◽  
Yuan-Yuan Gao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alcohol Use ◽  
Alcohol Abuse ◽  
Alcohol Dependence ◽  
Physical Abuse ◽  
Emotional Abuse ◽  
Alcohol Use Disorder ◽  
Alcohol Use Disorders ◽  
Traumatic Experience ◽  
Frequent Drinking

Abstract Background We aimed to investigate the effect of early-age (prenatal, infant, and childhood) trauma on adulthood alcohol use disorder. Methods A total number of 1534 subjects who were born and live in the city of Tangshan were selected. The subjects were divided into three age groups. General demographic data, conditions of the mothers during pregnancy, and condition of the babies at birth, were collected. The diagnosis of alcohol use disorder was based on Structured Clinical Interviews for DSM-IV Axis Disorders (patient version) (SCID). The childhood trauma questionnaire short form (CTQ-SF) [1] and the Lifetime of Experience Questionnaire (LTE-Q) [2] were used to evaluate stress in childhood and adulthood, respectively. Results Only male subjects were diagnosed with lifelong alcohol abuse and alcohol dependence. There was no statistically significant difference in the prevalence of lifetime alcohol use disorder (X2 = 4.480, P = 0.345), current alcohol abuse, and current alcohol dependence among the three groups (X2abuse = 2.177, X2depedence = 2.198, P > 0.05). However, higher prevalence of lifetime alcohol use disorders was found in group with higher scores of CTQ (X2 = 9.315, P = 0.009), emotional abuse (X2 = 8.025, P = 0.018), physical abuse (X2 = 20.4080, P < 0.001), but not in the group with higher scores of emotional neglect (X2 = 1.226, P = 0.542), sexual abuse (X2 = 2.779, P = 0.249), physical neglect (X2 = 3.978, P = 0.137), LTE-Q (X2 = 5.415, P = 0.067), and PSQI (X2 = 5.238, P = 0.073). Protective factor for alcohol abuse for men was identified to be heavy drinking (OR = 0.085, 95%CI: 0.011–0.661), and the risk factors for alcohol abuse were identified to be frequent drinking (OR = 2.736, 95%CI: 1.500, 4.988), and consumption of low liquor (OR = 2.563, 95%CI: 1.387, 4.734). Risk factors for alcohol dependence in males were identified to be consumption of low liquor (OR = 5.501, 95%CI: 2.004, 15.103), frequent drinking (OR = 2.680, 95%CI: 1.164, 6.170), and childhood physical abuse (OR = 2.310, 95% CI: 1.026, 5.201). Conclusion Traumatic experience during infant and prenatal periods does not have a strong statistical correlation with alcohol use disorders for male adults. However, subjects with high CTQ scores, experience of emotional abuse and physical abuse show a statistically higher prevalence of lifetime alcohol use disorders. Several risk factors including consumption of low liquor, frequent drinking, and childhood physical abuse contribute to alcohol dependence in male adults.

Externalizing and internalizing symptoms in childhood and adolescence and the risk of alcohol use disorders in young adulthood: A meta-analysis of longitudinal studies

2019 ◽  
Vol 53 (10) ◽  
pp. 965-975 ◽  
Author(s):  
Ivete Meque ◽  
Berihun Assefa Dachew ◽  
Joemer C Maravilla ◽  
Caroline Salom ◽  
Rosa Alati
Keyword(s):  
Alcohol Use ◽  
Young Adulthood ◽  
Odds Ratio ◽  
Internalizing Symptoms ◽  
Meta Analysis ◽  
Alcohol Use Disorders ◽  
Childhood And Adolescence ◽  
Statistical Manual ◽  
Diagnostic And Statistical Manual ◽  
Externalizing And Internalizing Symptoms

Background: Evidence suggests that externalizing and internalizing symptoms are expressed early in life and are associated with problematic drinking in young adulthood. However, few studies have examined their role during childhood and adolescence in predicting alcohol problems later in life. Objectives: To examine the role of childhood and adolescent externalizing and internalizing symptoms in predicting alcohol use disorders in young adulthood. Methods: We searched five electronic databases (PubMed, Scopus, PsycINFO, Web of Sciences and Embase) for studies which diagnosed alcohol use disorders through either the International Classification of Diseases or American Psychiatric Association – Diagnostic and Statistical Manual of Mental Disorders criteria and followed up children or adolescents into the transition to young adulthood. We performed a meta-analysis and obtained pooled odds ratio estimates with 95% confidence intervals using random-effects models. Results: A total of 12 longitudinal studies met eligibility criteria and were included in the meta-analysis. All measured the outcome using Diagnostic and Statistical Manual of Mental Disorders criteria. The majority were of good quality and were conducted in the United States. A total of 19,407 participants (50% female) were included in this meta-analysis. Of these, n = 2337 (12%) had diagnoses of alcohol use disorders/alcohol dependence. Participant ages ranged from birth to 36 years. Internalizing symptoms increased the risk of young adult alcohol use disorders by 21% (odds ratio = 1.21; 95% confidence interval = [1.05, 1.39]), with no strong evidence of publication bias. Subgroup analysis suggested significantly lower heterogeneity than for externalizing studies. Externalizing symptoms increased the risk of alcohol use disorders by 62% (odds ratio = 1.62, 95% confidence interval = [1.39, 1.90]). We found some evidence of publication bias and significant heterogeneity in the studies. Conclusion: Our findings highlight the contribution of early behavioural problems to the development of alcohol use disorders in young adulthood and the need for timely scrutiny of and intervention on early behavioural problems.

scholarly journals Gender differences in the structure of risk for alcohol use disorder in adolescence and young adulthood

2015 ◽  
Vol 45 (14) ◽  
pp. 3047-3058 ◽  
Author(s):  
K. T. Foster ◽  
B. M. Hicks ◽  
W. G. Iacono ◽  
M. McGue
Keyword(s):  
Risk Factors ◽  
Gender Differences ◽  
Alcohol Use ◽  
Psychosocial Factors ◽  
Internalizing Symptoms ◽  
Alcohol Use Disorder ◽  
Community Sample ◽  
Risk Exposure ◽  
Deviant Peer Affiliation ◽  
Adolescent Risk

Background.Gender differences in the prevalence of alcohol use disorder (AUD) have motivated the separate study of its risk factors and consequences in men and women. However, leveraging gender as a third variable to help account for the association between risk factors and consequences for AUD could elucidate etiological mechanisms and clinical outcomes.Method.Using data from a large, community sample followed longitudinally from 17 to 29 years of age, we tested for gender differences in psychosocial risk factors and consequences in adolescence and adulthood after controlling for gender differences in the base rates of AUD and psychosocial factors. Psychosocial factors included alcohol use, other drug use, externalizing and internalizing symptoms, deviant peer affiliation, family adversity, academic problems, attitudes and use of substances by a romantic partner, and adult socio-economic status.Results.At both ages of 17 and 29 years, mean levels of psychosocial risks and consequences were higher in men and those with AUD. However, the amount of risk exposure in adolescence was more predictive of AUD in women than men. By adulthood, AUD consequences were larger in women than men and internalizing risk had a stronger relationship with AUD in women at both ages.Conclusions.Despite higher mean levels of risk exposure in men overall, AUD appears to be a more severe disorder in women characterized by higher levels of adolescent risk factors and a greater magnitude of the AUD consequences among women than men. Furthermore, internalizing symptoms appear to be a gender-specific risk factor for AUD in women.

scholarly journals Risk Factors and Neuropsychological Recovery in Clients With Alcohol Use Disorders Who Were Exposed to Different Treatments.

2004 ◽  
Vol 72 (6) ◽  
pp. 1073-1080 ◽  
Author(s):  
Marsha E. Bates ◽  
Danielle Barry ◽  
Erich W. Labouvie ◽  
William Fals-Stewart ◽  
Gerald Voelbel ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alcohol Use ◽  
Alcohol Use Disorders

scholarly journals The point-prevalence of alcohol use disorders and binge drinking in an Irish general hospital

2006 ◽  
Vol 23 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Guy J Molyneux ◽  
Elizabeth Cryan ◽  
Elisa Dooley
Keyword(s):  
Risk Factors ◽  
Alcohol Use ◽  
Binge Drinking ◽  
General Hospital ◽  
Alcohol Use Disorder ◽  
Hospital Admissions ◽  
Adult Population ◽  
Alcohol Use Disorders ◽  
Point Prevalence ◽  
University Teaching

AbstractObjectives: There is a paucity of data concerning the prevalence of alcohol use disorders and binge drinking in the general hospital adult population in Ireland. We therefore examined the point-prevalence of alcohol use disorders and of binge drinking in the adult inpatient population of the acute wards of an Irish university teaching hospital. The secondary aim was to examine gender, age, and patient group (medical/surgical) as risk factors.Method: We administered the Alcohol Use Disorders Identification Test (AUDIT) to all consenting patients (n = 126) on the acute adult medical and surgical wards over one day.Results: 76% of all inpatients on the acute medical and surgical wards were interviewed (n = 126) using the AUDIT.Of the subjects 28% screened positive for an alcohol use disorder. Of these 91% were identified as binge drinkers.A further 8% of the subjects screened positive for binge drinking but were not identified as having an alcohol use disorder.Overall, 36% of the subjects screened positive for either an alcohol use disorder and/or for binge drinking using the AUDIT.Male gender and under 65s were risk factors for both alcohol use disorders and binge drinking.Conclusions: The high point-prevalences of alcohol use disorders and binge drinking in hospital inpatients in particular are a cause for concern as they may have illness complicated by or secondary to undiagnosed alcohol excess. As this population is an easily accessible group for screening, and clinical and economic evidence supports intervention, we recommend screening all acute hospital admissions for alcohol use disorders and binge drinking, followed by appropriate management.

scholarly journals OR02-4 * MODEL OF ALCOHOLICS WITH INACTIVE ALDH2: IDENTIFYING PERSONALITY RISK FACTORS FOR ALCOHOL USE DISORDERS

2014 ◽  
Vol 49 (suppl 1) ◽  
pp. i40-i40
Author(s):  
M. Itoh ◽  
T. Yonemoto ◽  
T. Takimura ◽  
A. Yoshimura ◽  
H. Sakuma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alcohol Use ◽  
Alcohol Use Disorders

scholarly journals Targeting the Gut Dysbiosis as a Treatment for Alcoholic Liver Disease

2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Shaikh GM ◽  
◽  
Gupta GL ◽  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Hepatitis C ◽  
Alcohol Use ◽  
Alcoholic Liver Disease ◽  
Alcohol Use Disorders ◽  
Review Article ◽  
Gut Dysbiosis ◽  
Intestinal Dysbiosis

Alcohol Use Disorders (AUD) originates due to heavy and uncontrolled drinking of alcohol. It is one of the most prevalent mental disorders, which predominantly affects men globally. In the review article alcohol use disorders and several risk factors like gender, drinking habit, genetic differences, and obesity Hepatitis C virus has been described for the provocation of intestinal dysbiosis. Alcoholic Liver Disease (ALD) is a spectrum of diseases from steatohepatitis to Hepatocellular Carcinoma (HCC). Due to dysbiosis, there are microbial changes also taking place in the liver and it further worsens the conditions. Treatment involves treating gut dysbiosis and altered balance of the micro-organism. The treatment strategy of ALD may also involve a non-dietary approach or dietary approach or by microbiota modulation.

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