A 36-Year-Old Woman With Cough, Positive Purified Protein Derivative Tuberculin Skin Test, and Cavitary Upper Lobe Consolidation

CHEST Journal ◽  
2010 ◽  
Vol 137 (4) ◽  
pp. 994-998
Author(s):  
Venktesh R. Ramnath ◽  
Rebecca A. Osgood
Keyword(s):  
Tuberculin Skin Test ◽  
Skin Test ◽  
Purified Protein Derivative

Mantoux Test in Kawasaki Disease

PEDIATRICS ◽  
1996 ◽  
Vol 98 (1) ◽  
pp. 161-161
Author(s):  
Alberto Bertotto ◽  
Fabrizio Spinozzi ◽  
Maurizio Radicioni ◽  
Renato Vaccaro
Keyword(s):  
Kawasaki Disease ◽  
Tuberculin Skin Test ◽  
Skin Test ◽  
Acute Phase ◽  
Mantoux Test ◽  
Skin Test Reactivity ◽  
Purified Protein Derivative ◽  
Characteristic Features ◽  
Early Manifestation

Localized erythema at the site of a previous bacillus Calmette-Guérin (BCG) inoculation is a relatively specific and early manifestation of Kawasaki disease (KD),1 and redness and crusting are characteristic features at the site of BCG immunization during the acute phase of the illness.2 With these findings in mind, we evaluated the tuberculin skin test reactivity of children with KD, as determined by a commercially available (Sclavo, Siena, Italy) and intradermally injected (5 TU) purified protein derivative (PPD).

The Interplay of Disease Modifying Anti Rheumatic Drugs and Tuberculin Skin Test

2020 ◽  
Vol 15 ◽  
Author(s):  
Zia Abdullah ◽  
Arvind Kumar ◽  
M. A. Khan ◽  
Uma Kumar ◽  
Surabhi Vyas ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Tuberculin Skin Test ◽  
Skin Test ◽  
Steroid Use ◽  
Purified Protein Derivative ◽  
Disease Modifying

Objective:: The study was conducted to determine whether synthetic disease modifying Anti Rheumatic drugs (DMARDs) suppresses the latency of Tuberculosis (TB) infection in Rheumatoid Arthritis (RA) patients along with other variables. Methods:: This was done through Tuberculin Skin Test (TST) using Purified protein derivative (PPD) in cohort of RA Patients. The TST was taken positive when induration post PPD injection was  5mm and negative or anergic when it was < 5mm. We included 100 patients (N = 100). Results:: The prevalence of positive TST was 36%, while 64% presented a negative result. Negative TST was significantly associated with steroid usage (39.4%, 95% CI: 28.4%-51.4%). Anergic (TST negative) and non-anergic (TST positive) patients were separated in groups, and a new analysis was done with elaboration on DMARDs used. Conclusion:: Steroid use and not treatment with methotrexate or other DMARDs was associated with TST negativity and thus TST should be interpreted with caution especially before starting biologicals.

scholarly journals The ID93 Tuberculosis Vaccine Candidate Does Not Induce Sensitivity to Purified Protein Derivative

2014 ◽  
Vol 21 (9) ◽  
pp. 1309-1313 ◽  
Author(s):  
Susan L. Baldwin ◽  
Valerie Reese ◽  
Brian Granger ◽  
Mark T. Orr ◽  
Gregory C. Ireton ◽  
...  
Keyword(s):  
Immune Responses ◽  
Tuberculin Skin Test ◽  
Skin Test ◽  
Vaccine Candidate ◽  
Cellular Responses ◽  
Mycobacterial Species ◽  
Content Type ◽  
Vaccine Candidates ◽  
Purified Protein Derivative ◽  
Diagnostic Use

ABSTRACTThe tuberculin skin test (TST) is a simple and inexpensive test to determine whether individuals have been exposed toMycobacterium tuberculosis. This test is not always reliable, however, in people previously immunized with BCG and/or who have been exposed to environmental mycobacterial species due to a reaction to purified protein derivative (PPD) used in the skin test. An issue with BCG, therefore, is that the resulting sensitization to PPD in some individuals compromises the diagnostic use of the skin test. The ability to induce protective immune responses without sensitizing to the tuberculin skin test will be important properties of next-generation tuberculosis (TB) vaccine candidates. We show here that guinea pigs immunized with the candidate TB vaccine ID93/GLA-SE, currently in clinical trials, do not react to intradermal PPD administration. In contrast, positive DTH responses to both ID93 and components thereof were induced in ID93/GLA-SE-immunized animals, indicating robust but specific cellular responses were present in the immunized animals. Noninterference with the TST is an important factor for consideration in the development of a vaccine againstM. tuberculosis.

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