scholarly journals Visceral Pleural Invasion Does Not Affect Recurrence or Overall Survival Among Patients With Lung Adenocarcinoma ≤ 2 cm

CHEST Journal ◽  
2013 ◽  
Vol 144 (5) ◽  
pp. 1622-1631 ◽  
Author(s):  
Jun-ichi Nitadori ◽  
Christos Colovos ◽  
Kyuichi Kadota ◽  
Camelia S. Sima ◽  
Inderpal S. Sarkaria ◽  
...  
Keyword(s):  
Overall Survival ◽  
Lung Adenocarcinoma ◽  
Pleural Invasion ◽  
Visceral Pleural Invasion

scholarly journals Use of Autofluorescence to Intraoperatively Diagnose Visceral Pleural Invasion From Frozen Sections in Patients With Lung Adenocarcinoma 2 cm or Less

2019 ◽  
Vol 152 (5) ◽  
pp. 608-615
Author(s):  
Huikang Xie ◽  
Hang Su ◽  
Donglai Chen ◽  
Dong Xie ◽  
Chenyang Dai ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Accurate Method ◽  
Sublobar Resection ◽  
Frozen Sections ◽  
Surgical Decision ◽  
Pleural Invasion ◽  
Visceral Pleural Invasion ◽  
Lung Adenocarcinomas ◽  
The Impact ◽  
Risk Factor For Recurrence

Abstract Objectives We prospectively investigate the accuracy of frozen sections for diagnosing visceral pleural invasion (VPI) by autofluorescence and evaluated its usefulness in sublobar resection. Methods We included patients with lung adenocarcinoma 2 cm or less to evaluate the diagnostic performance of autofluorescence for VPI in frozen sections via a fluorescence microscope. Furthermore, the impact of VPI on patients treated with sublobar resection was assessed in another cohort. Results A total of 112 patients were enrolled. The accuracy, sensitivity, and specificity of autofluorescence for VPI diagnosis was 95.5%, 86.8%, and 100%, respectively. Sublobar resection was an independent risk factor for recurrence in patients with lung adenocarcinomas 2 cm or less with VPI positivity (hazard ratio, 3.30; P = .023), whereas it was not in those with VPI negativity. Conclusions Using autofluorescence in frozen sections appears to be an accurate method for diagnosing VPI, which is helpful for surgical decision making.

Recurrence Pattern of Pathologic Stage I Lung Adenocarcinoma With Visceral Pleural Invasion

2017 ◽  
Vol 103 (4) ◽  
pp. 1126-1131 ◽  
Author(s):  
Dhihintia Jiwangga ◽  
Sukki Cho ◽  
Kwhanmien Kim ◽  
Sanghoon Jheon
Keyword(s):  
Lung Adenocarcinoma ◽  
Stage I ◽  
Recurrence Pattern ◽  
Pathologic Stage ◽  
Pleural Invasion ◽  
Visceral Pleural Invasion

scholarly journals P2.16-34 Visceral Pleural Invasion is Closely Associated with Nodal Spread in cStage IA Lung Adenocarcinoma

2018 ◽  
Vol 13 (10) ◽  
pp. S845 ◽  
Author(s):  
T. Mizuno ◽  
T. Arimura ◽  
H. Kuroda ◽  
N. Sakakura ◽  
Y. Yatabe ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Pleural Invasion ◽  
Visceral Pleural Invasion ◽  
Nodal Spread

Visceral Pleural Invasion Is a Significant Prognostic Factor in Patients with Partly Solid Lung Adenocarcinoma Sized 30 mm or Smaller

2016 ◽  
Vol 66 (02) ◽  
pp. 150-155 ◽  
Author(s):  
Yangki Seok ◽  
Eungbae Lee
Keyword(s):  
Computed Tomography ◽  
Multivariate Analysis ◽  
Lung Adenocarcinoma ◽  
Univariate Analysis ◽  
Disease Free Survival ◽  
Pulmonary Adenocarcinoma ◽  
Significant Prognostic Factor ◽  
Pleural Invasion ◽  
Visceral Pleural Invasion ◽  
The Impact

Background This study analyzed the impact of visceral pleural invasion (VPI) on the disease-free survival (DFS) of patients with partly solid pulmonary adenocarcinoma sized 30 mm or smaller. Method This is a retrospective study of 147 patients with surgically resected pathologic N0 pulmonary adenocarcinoma that had a partly solid appearance on preoperative computed tomography. All patients presented with tumors of size 30 mm or smaller. The DFS rate was estimated using Kaplan–Meier method. A multivariate analysis for prognostic factors was performed using the Cox proportional hazards regression model. Results VPI was found in 36 patients. The 5-year DFS in 111 patients without VPI (97.6%) was significantly higher than that in 36 patients with VPI (63%) (p < 0.0001). Univariate analysis revealed three significant poor prognostic predictors: the presence of VPI, the presence of lymphovascular invasion, and the size of the solid component on computed tomography (>20, ≤30 mm). According to the multivariate analysis, VPI was found to be a significant poor prognostic predictor (hazard ratio for DFS = 7.31, 95% confidence interval = 1.444–37.014, p = 0.016). Conclusion VPI is a significant predictor of poor prognosis for small-sized (≤30 mm) partly solid lung adenocarcinoma. Therefore, upstaging of the T factor from T1 to T2 on the basis of VPI as described by the TNM staging system is mandatory regardless of ground-glass opacity in small lung adenocarcinoma.

scholarly journals Ultra-High-Resolution CT Features of Pulmonary Nodules Correlate with Visceral Pleural Invasion in Early Stage Lung Adenocarcinoma

2021 ◽  
Author(s):  
Lu Li ◽  
Huimin Li ◽  
Jiangfeng Pan ◽  
Zhenwei Chen ◽  
Xiaorong Chen ◽  
...  
Keyword(s):  
High Resolution ◽  
Lung Adenocarcinoma ◽  
Early Stage ◽  
Tnm Classification ◽  
Area Under The Curve ◽  
Pulmonary Nodules ◽  
High Resolution Computed Tomography ◽  
Solid Ratio ◽  
Pleural Invasion ◽  
Visceral Pleural Invasion

Abstract Backgroundvisceral pleural invasion (VPI) is an important prognostic factor in early stage lung adenocarcinoma, which can affect the TNM Classification of Tumors.PurposeTo investigate whether ultra-high-resolution computed tomography (U-HRCT) features can predict VPI of early stage pulmonary nodules contacting the interlobar pleura.Material and MethodsA total of 126 patients with lung adenocarcinoma (age, 24-77 years) confirmed by surgical pathology were retrospectively enrolled. All patients underwent U-HRCT scan and were divided into two groups according to pulmonary nodular type: pure (pGGN) and mixed (mGGN). Clinical features were recorded, and U-HRCT features were manually measured using PHILIPS EBW V4.5.5. Univariate and multivariate logistic regression were used to determine factors that can significantly predict VPI. ResultsU-HRCT and three-dimensional orthogonal post-processing method could better display the relationship between GGNs and interlobar fissures. Among all patients, fifteen patients (12%) had VPI. None of the patients with pGGN had VPI. In the mGGN group, the solid ratio (odds ratio [OR]=1.275, 95% CI 1.1-1.478; P=0.001) and solid diameter (OR=1.139, 95% CI 1.06-2.346; P=0.046) were independent risk factors for VPI in early stage lung adenocarcinoma. For VPI diagnosis, the area under the curve, sensitivity, and specificity of the solid ratio and solid diameter were 0.803, 80%, and 75% and 0.807, 80%, and 80.36%, respectively.ConclusionU-HRCT can display GGNs and interlobar fissures in detail. VPI was not detected in patients with pGGN. In patients with mGGNs, a solid diameter >6mm and solid ratio >38% can be independent predictors of VPI, which may be helpful in surgical decision-making.

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