Interferon-γ in the Treatment of Infectious Diseases

2003 ◽  
pp. 331-344
Author(s):  
Steven M. Holland ◽  
John I. Gallin
Keyword(s):  
Infectious Diseases ◽  
Interferon Γ

scholarly journals Neopterin - a potential diagnostic and prognostic marker in infection diseases

2014 ◽  
Vol 95 (6) ◽  
pp. 938-943 ◽  
Author(s):  
K R Dudina ◽  
M M Kutateladze ◽  
O O Znoiko ◽  
N O Bokova ◽  
S A Shutko ◽  
...  
Keyword(s):  
Immune Response ◽  
Infectious Diseases ◽  
High Performance ◽  
Biological Fluids ◽  
Transplant Rejection ◽  
Interferon Γ ◽  
Pathological Process ◽  
Enzyme Linked Immunosorbent Assay ◽  
Specific Marker ◽  
Vector Borne Diseases

Clinical significance of determining the neopterin concentration in body fluids is reviewed. The results of researches on determining the neopterin concentrations in various infectious diseases (vector-borne diseases, herpes, respiratory and intestinal infections, as well as human immunodeficiency virus infection) conducted over the past 2 years are discussed. Neopterin is a biologically stable metabolite, which gives an advantage of its detection to assess the activity of the immune response. Previously neopterin was determined mainly by high-performance liquid chromatography. In recent years, enzyme-linked immunosorbent assay was introduced and frequently used for determining neopterin concentrations. It was shown that neopterin concentrations can vary also in the absence of the pathological process. In particular, some general factors such as race, age, body mass index, smoking and arterial pressure may influence on the concentrations of neopterin in the human body. Increased level of neopterin in body biological fluids and the kynurenine/tryptophan ratio are measured in diseases involving interferon-γ-mediated immune response activation. In this regard, the highest concentrations of neopterin and increased kynurenine/tryptophan ratio are observed in cases of infectious diseases, malignancies, transplant rejection, a number of cardiovascular and autoimmune diseases. It was shown that neopterin can be regarded as a highly specific marker of viral infection, and its blood concentration reflect the prognosis of the disease. Monitoring neopterin level may be useful to assess the severity and activity of an infectious disease, its clinical course, and to control the effectiveness of etiological treatment for many infectious diseases.

scholarly journals Tissue-specific down-regulation of RIPK 2 inMycobacterium leprae-infected nu/nu mice

2004 ◽  
Vol 13 (1) ◽  
pp. 51-52 ◽  
Author(s):  
Byoung Chul Kim ◽  
Tae-Jin Kang ◽  
Song Hou Jin ◽  
Se-Kon Kim ◽  
Seong-Boem Lee ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Mycobacterium Leprae ◽  
Mycobacterial Infection ◽  
Interferon Γ ◽  
Signal Pathway ◽  
Toll Like Receptors ◽  
Serine Threonine Kinase ◽  
Down Regulation ◽  
Threonine Kinase ◽  
Adapter Molecule

RIPK 2 is adapter molecule in the signal pathway involved in Toll-like receptors. However, there has been no reported association between receptor-interacting serine/threonine kinase 2 (RIPK 2) expression and the infectious diseases involving mycobacterial infection. This study found that its expression was down-regulated in the footpads and skin but was up-regulated in the liver ofMycobacterium leprae-infected nu/nu mice compared with those of theM. lepraenon-infected nu/nu mice. It was observed that the interlukin-12p40 and interferon-γ genes involved in the susceptibility ofM. lepraewere down-regulated in the skin but were up-regulated in the liver. Overall, this suggests that regulation of RIPK 2 expression is tissue-specifically associated withM. lepraeinfection.

P1709THE ROLE OF CXCL9 AND CXCL13 IN PREDICTION OF POSTTRANSPLANT INFECTION IN KIDNEY TRANSPLANT RECIPIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Yangjuan Bai ◽  
Lin Yan ◽  
Yi Li ◽  
Yamei Li ◽  
Xianding Wang ◽  
...  
Keyword(s):  
Serum Level ◽  
Infectious Diseases ◽  
Kidney Transplant ◽  
Kidney Diseases ◽  
Interferon Γ ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Suspension Array ◽  
One Year

Abstract Background and Aims Chemokines are deeply involved in the process of inflammatory and immune responses. Interferon-γ-inducible chemokines C-X-C motif chemokine 9 and 10 (CXCL9 and CXCL10) are significantly associated with Th1 cells and monocytes and rise rapidly during early episode of renal allograft rejection and various infectious diseases. CXCL13 is one of the most potent B cells and T follicular helper (Tfh) cells chemoattractants when acts through its cognate receptor CXCR5. Recent work of CXCL13 indicated a critical immune regulatory role in both multiple infectious diseases and kidney transplantation. Additionally, C-C motif chemokine 2 (CCL2) is shown to be is critical for chronic kidney diseases. The aim of this study was to identify the predictive role of serum CXCL9, CXCL10, CXCL13 or CCL2 on kidney posttransplant infection. Method 95 kidney transplant recipients (KTRs) were enrolled in this study. 31 recipients experienced at least once infection episodes within the first posttransplant 12 months and 64 KTRs did not experience any infection episode during the follow-up period. Serum CXCL9, CXCL10, CXCL13 and CCL2 at the time points of pre-transplantation and post-transplant 30 days (POD 30) were analyzed with Bio-Plex® suspension array system. Results It was found that serum level of POD 30 CXCL9 and POD 30 CXCL13 was associated with infection within one year after transplantation (P=0.021, P=0.002, respectively, shown in Figure 1). The serum level of CXCL9 and CXCL13 before surgery, the serum level of CCL2 and CXCL10 before and after surgery were not associated with infection within posttransplant one year (P>0.05, shown in Figure 1). The combination of POD 30 CXCL9 plus POD 30 CXCL13 provided the best results with AUC of 0.721 (95%CI, 0.591-0.852), sensitivity of 71.4% and specificity of 68.5% at the optimal cut-off value of 52.72 pg/ml (shown in Figure 2). Conclusion Chemokines CXCL9 and CXCL13 as important chemokines could be used to predict the occurrence of infection within posttransplant one year in kidney transplant recipients.

scholarly journals Lac water extract inhibits IFN-γ signaling through JAK2-STAT1-IRF1 axis in human melanoma

RSC Advances ◽  
2018 ◽  
Vol 8 (38) ◽  
pp. 21534-21540
Author(s):  
Luhui Li ◽  
Satoru Yokoyama ◽  
Na Han ◽  
Yoshihiro Hayakawa
Keyword(s):  
Infectious Diseases ◽  
Host Defense ◽  
Immune Surveillance ◽  
Tumor Development ◽  
Water Extract ◽  
Interferon Γ ◽  
Human Melanoma ◽  
Ifn Γ

Interferon-γ (IFN-γ) is a cytokine that plays an important role in the host defense of infectious diseases and in immune surveillance during tumor development.

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