Preparation and Characterization of Polyethylene Glycol Coating Iron Oxide Nanoparticles for Curcumin Delivery

The PEG-coated iron oxide nanoparticles (Fe3O4 NPs-PEG) was synthesized by coprecipitation and ultrasonication method. X-ray diffraction results exhibited that the average size of Fe3O4 NPs-PEG was 19.10 nm, which was further confirmed in TEM imaging. In addition, sonication time and curcumin concentration were studied to evaluate the efficiency of loading curcumin onto Fe3O4 NPs-PEG. Further, statistical optimization using response surface methodology (RSM) has shown curcumin concentration (0,01% w/v) and sonication time (21 min) for maximal curcumin loading (0.37 mg/g). Along with the magnetization studies, the immobilization of curcumin onto the Fe3O4 NPs-PEG was characterized by UV, FTIR and SEM. The results showed that the curcumin loaded PEG coated iron oxide nanoparticles could potentially be used for magnetically target drug delivery.

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Synthesis of Iron Oxide Nanoparticles Using Isobutanol

Journal of Nanomaterials ◽

10.1155/2016/4982675 ◽

2016 ◽

Vol 2016 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Diana Kostyukova ◽

Yong Hee Chung

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Ammonium Hydroxide ◽

Oxide Nanoparticles ◽

X Ray Diffraction ◽

Ferrous Chloride ◽

X Ray ◽

Superparamagnetic Properties

Iron oxide nanoparticles were synthesized by precipitation in isobutanol with sodium hydroxide and ammonium hydroxide. The isobutanol played a role of a surfactant in the synthesis. The nanoparticles were calcined for 100 min to 5 hours in the range of 300 to 600°C. The characterization of the samples by FTIR (Fourier-transform infrared) and XRD (X-ray diffraction) confirmed the formation ofγ-Fe2O3(maghemite) from Fe3O4(magnetite) at calcination at 300°C. The morphology and particle size were studied by SEM (scanning electron microscope). Nanoparticles in the range of 11–22 nm prepared at 0.09 M of ferrous chloride exhibited superparamagnetic properties. Nanoparticles synthesized with ferrous chloride and ammonium hydroxide at 75°C and calcined at 530°C for 2 h wereα-Fe2O3(hematite).

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Macrophage-Laden Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Enhanced Dual-Mode CT/MR Imaging of Tumors

Pharmaceutics ◽

10.3390/pharmaceutics13070995 ◽

2021 ◽

Vol 13 (7) ◽

pp. 995

Author(s):

Yucheng Peng ◽

Xiaomeng Wang ◽

Yue Wang ◽

Yue Gao ◽

Rui Guo ◽

...

Keyword(s):

Iron Oxide ◽

Mr Imaging ◽

Iron Oxide Nanoparticles ◽

Colloidal Stability ◽

Pamam Dendrimer ◽

Great Promise ◽

Oxide Nanoparticles ◽

Dual Mode ◽

Gold Nanoflowers ◽

Average Size

The design of multimodal imaging nanoplatforms with improved tumor accumulation represents a major trend in the current development of precision nanomedicine. To this end, we report herein the preparation of macrophage (MA)-laden gold nanoflowers (NFs) embedded with ultrasmall iron oxide nanoparticles (USIO NPs) for enhanced dual-mode computed tomography (CT) and magnetic resonance (MR) imaging of tumors. In this work, generation 5 poly(amidoamine) (G5 PAMAM) dendrimer-stabilized gold (Au) NPs were conjugated with sodium citrate-stabilized USIO NPs to form hybrid seed particles for the subsequent growth of Au nanoflowers (NFs). Afterwards, the remaining terminal amines of dendrimers were acetylated to form the dendrimer-stabilized Fe3O4/Au NFs (for short, Fe3O4/Au DSNFs). The acquired Fe3O4/Au DSNFs possess an average size around 90 nm, display a high r1 relaxivity (1.22 mM−1 s−1), and exhibit good colloidal stability and cytocompatibility. The created hybrid DSNFs can be loaded within MAs without producing any toxicity to the cells. Through the mediation of MAs with a tumor homing and immune evasion property, the Fe3O4/Au DSNFs can be delivered to tumors more efficiently than those without MAs after intravenous injection, thus significantly improving the MR/CT imaging performance of tumors. The developed MA-mediated delivery system may hold great promise for enhanced tumor delivery of other contrast agents or nanomedicines for precision cancer nanomedicine applications.

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Synthesis of Iron Oxide Nanoparticles by Different Methods and Study of their Properties

Solid State Phenomena ◽

10.4028/www.scientific.net/ssp.230.108 ◽

2015 ◽

Vol 230 ◽

pp. 108-113 ◽

Cited By ~ 12

Author(s):

O.V. Yelenich ◽

S.O. Solopan ◽

T.V. Kolodiazhnyi ◽

Jean Marc Greneche ◽

Anatolii G. Belous

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Zero Field ◽

X Ray Diffraction ◽

Magnetic Studies ◽

Brij 35 ◽

Cryochemical Synthesis ◽

Specific Loss Power ◽

Triton X

In this work, iron oxide nanoparticles have been synthesized by precipitation in diethylene glycol, by cryochemical synthesis, in microemulsions using surfactants Triton X-100, Brij-35 and CTAB. Comparative spectroscopic, thermal, X-ray diffraction, 57Fe zero-field Mössbauer and magnetic studies of the synthesized nanoparticles have been carried out. Magnetic fluids prepared from synthesized nanopowders have been characterized by calorimetric measurements of specific loss power (SLP).

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X-ray scattering characterization of iron oxide nanoparticles Langmuir film on water surface and on a solid substrate

Thin Solid Films ◽

10.1016/j.tsf.2016.07.060 ◽

2016 ◽

Vol 616 ◽

pp. 43-47 ◽

Cited By ~ 4

Author(s):

V. Ukleev ◽

A. Khassanov ◽

I. Snigireva ◽

O. Konovalov ◽

A. Vorobiev

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Water Surface ◽

Solid Substrate ◽

Oxide Nanoparticles ◽

Langmuir Film ◽

X Ray ◽

X Ray Scattering ◽

Ray Scattering

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Thermal, Mechanical and Magneto-Mechanical Characterization of Liquid Crystalline Elastomers Loaded with Iron Oxide Nanoparticles

MRS Proceedings ◽

10.1557/opl.2015.35 ◽

2015 ◽

Vol 1718 ◽

pp. 3-7

Author(s):

Stephany Herrera-Posada ◽

Barbara O. Calcagno ◽

Aldo Acevedo

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Liquid Crystalline ◽

Molar Mass ◽

Oxide Nanoparticles ◽

Magnetic Actuation ◽

Scanning Calorimetry ◽

Elastomeric Matrix ◽

Alternating Magnetic Fields

ABSTRACTLiquid crystalline elastomers (LCEs) are materials that reveal unusual mechanical, optical and thermal properties due to their molecular orientability characteristic of low molar mass liquid crystals while maintaining the mechanical elasticity distinctive of rubbers. As such, they are considered smart shape-changing responsive systems. In this work, we report on the preparation of magnetic sensitized nematic LCEs using iron oxide nanoparticles with loadings of up to 0.7 wt%. The resultant thermal and mechanical properties were characterized by differential scanning calorimetry, expansion/contraction experiments and extensional tests. The magnetic actuation ability was also evaluated for the neat elastomer and the composite with 0.5 wt% magnetic content, finding reversible contractions of up to 23% with the application of alternating magnetic fields (AMFs) of up to 48 kA/m at 300 kHz. Thus, we were able to demonstrate that the inclusion of magnetic nanoparticles yields LCEs with adjustable properties that can be tailored by changing the amount of particles embedded in the elastomeric matrix, which can be suitable for applications in actuation, sensing, or as smart substrates.

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Synthesis and characterization of superparamagnetic iron-oxide nanoparticles (SPIONs) and utilization of SPIONs in X-ray imaging

Applied Nanoscience ◽

10.1007/s13204-017-0583-x ◽

2017 ◽

Vol 7 (7) ◽

pp. 463-475 ◽

Cited By ~ 20

Author(s):

C. Justin ◽

Sheryl Ann Philip ◽

Antony V. Samrot

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Synthesis And Characterization ◽

Oxide Nanoparticles ◽

X Ray ◽

X Ray Imaging

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Thermoresponsive hybrid double-crosslinked networks using magnetic iron oxide nanoparticles as crossing points

Polymer Chemistry ◽

10.1039/c8py01006d ◽

2018 ◽

Vol 9 (37) ◽

pp. 4642-4650 ◽

Cited By ~ 4

Author(s):

Thomas Blin ◽

Antoine Niederberger ◽

Lazhar Benyahia ◽

Jérôme Fresnais ◽

Véronique Montembault ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Alder Reaction ◽

Diels Alder ◽

Oxide Nanoparticles ◽

Magnetic Iron Oxide Nanoparticles ◽

Diels Alder Reaction ◽

Crosslinked Networks ◽

Stimuli Sensitive

Preparation and characterization of stimuli-sensitive hybrid double-crosslinked hydrogels based on iron oxide nanoparticles as the nano-crosslinkers and a difuran-functionalized PEO as the diene partner for the thermoreversible Diels–Alder reaction.

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